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- Fegraeus, K. Jaderkvist, et al.
(författare)
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Different DMRT3 Genotypes Are Best Adapted for Harness Racing and Riding in Finnhorses
- 2015
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Ingår i: Journal of Heredity. - : Oxford University Press (OUP). - 0022-1503 .- 1465-7333. ; 106:6, s. 734-740
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies showed a positive effect of the DMRT3 "gait keeper" mutation on harness racing performance in Standardbreds, French-, and Nordic trotters. The mutation has also been shown to influence riding traits in multiple breeds. This study investigated the effect of the DMRT3 mutation on harness racing performance and riding traits in Finnhorses. Finnhorses used for harness racing (n = 180) and for riding (n = 59) were genotyped for the DMRT3 mutation. For the trotters the genotypes were evaluated for association with racing performance (number of starts, victories, placings, earnings, and race times). At 3-6 years of age the AA genotype was superior compared with the CA and CC genotypes. The AA horses had a significantly higher proportion of victories (P = 1.4 x 10(-6)) and placings (P = 4.1 x 10(-7)), better race times (P = 0.01), and earned more money (P = 0.009) compared with C-horses. For the Finnhorses used for riding the owners answered a questionnaire to score how well the horse performed the gaits walk, trot, and canter on a scale from 1 to 6. These scores were tested for association with the DMRT3 genotypes. Although AA horses were more successful as racehorses, the CC and CA horses appear more adapted for classical riding disciplines. The AA horses received significantly lower gait scores compared with C-horses for the majority of gaits. Except for rhythm in extended canter (P = 0.05), there were no significant differences between CA and CC horses. This study shows that there are different optimal genotypes for different disciplines and the DMRT3 mutation clearly influences gaits and performance in Finnhorses.
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| 2. |
- Jäderkvist Fegraeus, Kim, et al.
(författare)
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The DMRT3 “Gait keeper” mutation affects harness racing performance and riding traits in Finnhorses
- 2015
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Ingår i: Journal of Equine Veterinary Science. - : Elsevier BV. - 0737-0806 .- 1542-7412. ; 35, s. 399-399
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The DMRT3 "Gait keeper" mutation is well known for its effects on gaits and locomotion patterns in horses. Previous studies have shown the mutation to have a strong favorable effect on harness racing performance in Standardbreds, French and Nordic trotters. The mutation also affects riding traits in Icelandic horses and in Standardbreds. The aim of this study was to investigate the effect of the DMRT3 mutation on harness racing performance and riding traits in Finnhorses. We genotyped for the DMRT3 mutation 180 Finnhorses of trotting type and 59 Finnhorses used for riding. For the trotters the genotypes were evaluated for association with racing performance traits (number of starts, victories, placings, earnings and race times) at different ages. For the Finnhorses used for riding the owners answered a 12 question survey about their horse and had to score how well the horse performed the gaits walk, trot and canter on a scale from 1 to 6. T€olt and pace ability was also reported. These scores were then tested for an association with the DMRT3 genotypes. Racing performance analyses were performed usingWald tests in PLINK. Fisher's exact tests in R were used for analyses on t€olt and pace ability, while pairwise t-tests were used for gait score analyses. The results showed that the DMRT3 mutation strongly influenced racing performance in Finnhorses. Between 3 and 6 years of age AA horses had a significantly higher proportion of victories (P ¼ 1.4 106) and placings (P ¼ 4.1 107) compared with C- horses. Additionally, they also had better race times (P ¼ 0.01) and earned more money (P ¼ 0.009). Despite CA horses not performing as well as AA horses, they still performed better than CC horses. Thus supporting an additive genetic effect of the DMRT3 mutation on racing performance. Similar results were found when comparing performance at different ages (4, 5, 6 and 10 years), except for 3 years of age where no significant differences were present. Although AA horses were more successful as racehorses, the C- horses appear more adapted for classical riding disciplines. This is supported by significantly lower gait scores for AA horses compared with C- horses for the majority of gaits. With the exception of rhythm in extended canter (P ¼ 0.05), no significant differences were present between CA and CC horses for gait scores. A significant association (P ¼ 0.006) between DMRT3 genotype and the ability to show t€olt was present; however, no significant association was present for pace (P ¼ 0.21). This study shows that different genotypes are optimal for different disciplines and the DMRT3 mutation clearly influences the pattern of locomotion in Finnhorses.
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| 5. |
- Andersson, Cecilia, et al.
(författare)
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"Vad förväntas av en?" : Upplevelser av "idealstudenten" och mötet med universitetet
- 2024
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Ingår i: Lifelong Learning and Higher Education: New (and Old) Perspectives : Proceedings from the 2022 Lund University Conference on Teaching and Learning - Proceedings from the 2022 Lund University Conference on Teaching and Learning. - 9789172674844 - 9789172674851 ; , s. 35-53
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Konferensbidrag (refereegranskat)abstract
- Swedish institutions of higher education must promote widening participation. This goal is also expressed in policy documents at Lund University. To accomplish this, teachers at Lund University formed a group to strategically work towards student inclusion. This article reports on an interview study conducted by this group investigating students’ experiences and perceptions of entering education at two different programs. The theory of “the ideal student” was used to analyze the interview material. The result indicates the need for clarity and predictability in course layout and teaching.
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| 6. |
- Andersson, David A., et al.
(författare)
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TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Delta(9)-tetrahydrocannabiorcol
- 2011
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for analgesics. Here we show that the antinociceptive effects of spinal and systemic administration of acetaminophen (paracetamol) are lost in Trpa1(-/-) mice. The electrophilic metabolites N-acetyl-p-benzoquinoneimine and p-benzoquinone, but not acetaminophen itself, activate mouse and human TRPA1. These metabolites also activate native TRPA1 and, as a consequence, reduce voltage-gated calcium and sodium currents in primary sensory neurons. The N-acetyl-p-benzoquinoneimine metabolite l-cysteinyl-S-acetaminophen was detected in the mouse spinal cord after systemic acetaminophen administration. In the hot-plate test, intrathecal administration of N-acetyl-p-benzoquinoneimine, p-benzoquinone and the electrophilic TRPA1 activator cinnamaldehyde produced antinociception that was lost in Trpa1(-/-) mice. Intrathecal injection of a non-electrophilic cannabinoid, Delta(9)-tetrahydrocannabiorcol, also produced TRPA1-dependent antinociception in this test. Our study provides a molecular mechanism for the antinociceptive effect of acetaminophen and discloses spinal TRPA1 activation as a potential pharmacological strategy to alleviate pain.
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