| 1. |
- Balldin, Jan, 1935, et al.
(författare)
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Inverse relationship between central serotonergic neurotransmission and blood pressure in alcohol-dependent male subjects
- 2006
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Ingår i: Journal of Neural Transmission. ; 113, s. 1511-1517
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Tidskriftsartikel (refereegranskat)abstract
- Data has accumulated indicating an inverse relation between central serotonergic (5-HT) neurotransmission and blood pressure in hypertensive rats and in healthy individuals. The present study aimed to elucidate whether an inverse relation exists between systolic (SBP) and diastolic (DBP) blood pressure levels and central 5-HT neurotransmission also in a group of alcohol-dependent individuals. Central 5-HT neurotransmission was assessed by using the maximum prolactin (PRL) responses to the 5-HT probe DL-fenfluramine (DL-FEN; 60 mg po.) in 17 alcohol-dependent male subjects investigated during a period of on-going alcohol intake. BP was measured immediately before all time points for blood sampling, and readings before DL-FEN administration were used as the subjects resting BP. Results showed that there were inverse correlations between the maximum PRL responses to DL-FEN and the SBP levels (r = -0.57, p < 0.002) and with the DBP levels (r = -0.52, p < 0.05), respectively. The present study suggests the existence of an association between central 5-HT neurotransmission and blood pressure regulation also in alcohol-dependent individuals.
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| 2. |
- Bergsjö, Dag Henrik, 1980, et al.
(författare)
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Industrial Scale Production of Customized Ceramic Prostheses
- 2014
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Ingår i: Advanced Ceramics for Dentistry, 1st Edition. ; , s. 416-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Today, there are many solutions for dental rehabilitation. A damaged tooth can be replaced with a dental crown, and a toothless patient can be rehabilitated with implants and a corresponding bridge set-up. Traditionally, a dental crown is manufactured by veneering porcelain to a metal surface that is obtained through the use of casting principles. Implant rehabilitations used to rely on a high degree of handcraft by the dentist, where freehand drilling into the jaw- bone was supported by X-ray pictures and was done before implant insertion. Crown and implant rehabilitations can be provided at a much higher degree of industrialization by means of mass customization. The most common dental rehabilitations are crown restorations for single teeth, while full arch implant rehabilitations are the most comprehensive treatments. Trends in industry lean toward a higher degree of automation in production and manufacturing where key characteristics of a well-functioning ceramic prosthesis are cost reduction, patient satisfaction, and quality in both function and perception.
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| 3. |
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| 4. |
- Kero, Timo, 1973, et al.
(författare)
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A Method for Improving Dental Crown Fit-Increasing the Robustness
- 2010
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Ingår i: International Journal of Medicine and Medical Sciences. - 2073-2686. ; 1:3, s. 185-192
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Tidskriftsartikel (refereegranskat)abstract
- The introduction of mass-customization has enablednew ways to treat patients within medicine. However, theintroduction of industrialized treatments has also meant newobstacles. The purpose of this study was to introduce andtheoretically test a method for improving dental crown fit. The optimization method allocates support points in order to check the final variation for dental crowns. Three different types of geometries were tested and compared. The three geometries were also divided into three sub-geometries: Current method, Optimized method and Feasible method. The Optimized method, using the whole surface for support points, provided the best results. The results support the objective of the study. It also seems that the support optimization method can dramatically improve the robustness of dental crown treatments.
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| 5. |
- Kero, Timo, 1973, et al.
(författare)
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ASSESSING METHODS FOR MANAGEMENT OF R&D PROCESS INFORMATION
- 2009
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Ingår i: International Association for Management of Technology, IAMOT 2009 Proceedings.
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Konferensbidrag (refereegranskat)abstract
- In this paper a new method incorporating flexible collection of process information along with an intuitive manner of presenting the processes along with the process information is presented and compared to a standard DSM process chart. A prototype tool implementing the proposed method is also presented.A bio-medical process is mapped using interviews and available documentation from Nobel Biocare as the main method to collect process information. The complete model is documented applying a DSM tool. The proposed interactive process modeling (IPM) method has been developed in parallel with the mapped process, along with a prototype process documentation tool, to map the same process and compare the two mapping cases.The studied process contains 101 process activities that have been mapped and described using the two methods (DSM and the new interactive process mapping (IPM)). It has been found that the IPM method enables a more complete approach to process improvement since it can be applied and updated easier because of features such as: version control, higher level of user interactivity, alternative representations of process properties using links between information objects, IT-resources and organizational roles within the process chart.A flexible approach using the IPM method ensures rich and easily accessible process information that is easier to interpret, communicate and maintain over time than the standard DSM model.
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| 6. |
- Kero, Timo, 1973, et al.
(författare)
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Method for Analyzing Probe Scanned Surfaces
- 2008
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Ingår i: PROCEEDINGS OF THE 10TH WSEAS INTERNATIONAL CONFERENCE ON AUTOMATIC CONTROL, MODELLING & SIMULATION (ACMOS'08). - 1790-5117. - 9789606766633 ; 2008, s. 192-199
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Konferensbidrag (refereegranskat)abstract
- Probe scanning is widely used in modern dental industry, which is why it is important for the scanning process to be accurate for both hardware and software. Due to the wide range of scanner manufacturers with different types of surface registration algorithms it is of interest to in an analytical way evaluate the successfulness of the scanning. If the surface is registered in a successful way it also increases the probability of fortunate re-engineering of the intended object based on the scanning. The rationale of the study is that a well represented scanning result is essential for the manufacturing, internal fit and strength of a coping. The purpose of this paper is to propose a general method that enables analysis of the successfulness of the representation of probe scanning, and an optimization of the scanning. Twenty-four scans of a premolar preparation die were made in order to demonstrate the cause and effect relationship between alignment, central revolution axis of the probe and the representation of the result. Three scans were made for each of 8 alignments of the die. First the central revolution axis of the scanner was set in the concavity between the 2 convexities of the die. In the second scan, the central revolution axis of the scanner was set slightly to the left of the higher convexity of the die. For the third scan, the central revolution axis was set on the maximum of the higher convexity. The fundamental idea of the method is that, by confining a triangulated surface representation, from the scan and the scanned object, to surfaces based on the probe tip geometry, a value for the accuracy of each triangle can be determined. When the position of the central revolution axis and the alignment were optimized the poor areas with a predefined tolerance between 0.05 mm and 1.25 mm than were reduced by a factor of 14. By optimizing scanning, better scan results can be achieved, which is desirable for the internal fit, strength and manufacturing of the coping.
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| 7. |
- Kero, Timo, 1973, et al.
(författare)
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Process Optimization Regarding Geometrical Variation and Sensitivity Involving Dental Drill- and Implant-Guided Surgeries
- 2007
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Ingår i: International Journal of Biomedical Sciences. ; 2:4, s. 237-243
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Tidskriftsartikel (refereegranskat)abstract
- Within dental-guided surgery, there has been a lack of analytical methods for optimizing the treatment of the rehabilitation concepts regarding geometrical variation. The purpose of this study is to find the source of the greatest geometrical variation contributor and sensitivity contributor with the help of virtual variation simulation of a dental drill- and implant-guided surgery process using a methodical approach. It is believed that lower geometrical variation will lead to better patient security and higher quality of dental drill- and implant-guided surgeries. It was found that the origin of the greatest contributor to the most variation, and hence where the foci should be set, in order to minimize geometrical variation was in the assembly category (surgery). This was also the category that was the most sensitive for geometrical variation.
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| 8. |
- Kero, Timo, 1973, et al.
(författare)
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VARIATION SIMULATION TOOLKIT FOR VIRTUAL VERIFICATION OF DENTAL DRILL-GUIDED SURGERIES
- 2007
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Ingår i: III INTERNATIONAL CONGRESS ON COMPUTATIONAL BIOENGINEERING. - 9789806939103 ; , s. 333-338
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Konferensbidrag (refereegranskat)abstract
- . Guided surgeries are becoming common in modern dental industry, and are used for a variety of treatments. The purpose of this study is to apply a dental software toolkit for virtual simulation of dental drill guided surgery. The hypothesis is that if a virtual simulation of dental drill guided surgery can be done, then the preplanned surgery can also be verified before the actual surgery. The dental drill guided concept is a planning and surgical implementation system that enables surgery with the help of a drill guide based on planning supported by computer aided design tools and CT-scan. The variation simulation predicts the final positions of the pre-defined critical production dimension at the apical part of the fixture. The results are based on variation simulation of two dental drill guided surgeries: Maxilla, seven implants and Mandible, nine implants. Maxilla resulted in a safe surgery while Mandible needed an optimization of the implant positions before the surgery. By analyzing the results, it was also found that both plans could be optimized in order to minimize the geometrical variation. Finally, it was found that the method used was suitable for predicting guided surgeries to achieve safer treatments.
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| 9. |
- Kero, Timo, 1973, et al.
(författare)
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Virtual variation simulation of CAD/CAM template-guided surgeries performed on human cadavers: Part II
- 2010
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Ingår i: Journal of Prosthetic Dentistry. - 0022-3913 .- 1097-6841. ; 104:1, s. 48-55
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Tidskriftsartikel (refereegranskat)abstract
- Material and methodsSeventeen computer-aided plans were used for virtual variation simulation of surgeries conducted on 17 human cadavers and 145 implants placed in the cadavers. For each surgery, 10,000 virtual surgeries were performed, resulting in 1,450,000 implant placements. The results from the virtual variation simulations were statistically compared with the results from the actual surgeries. The Mann-Whitney U test was used to compare the implant distributions (α=.05).ResultsIn the maxillae, the difference between the simulated average mean of the mean and the compared surgical average of the median was 0.22 mm (apex) and −0.35 mm (hex), and for the mandible, the corresponding values were −0.19 mm (apex) and −0.69 mm (hex). The simulated average mean of the range compared to the mean range of the maximum deviation results from the surgeries of the maxillae was 2.96 mm (apex) and 0.44 mm (hex), and 2.3 mm (apex) and 0.26 mm (hex) for the mandible. The implant distributions between the simulations and the surgeries were significantly different at both the hex (P
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