| 1. |
- Andersson, Niklas, 1970, et al.
(författare)
-
Investigation of central versus peripheral effects of estradiol in ovariectomized mice
- 2005
-
Ingår i: J Endocrinol. - : Bioscientifica. - 0022-0795 .- 1479-6805. ; 187:2, s. 303-9
-
Tidskriftsartikel (refereegranskat)abstract
- It is generally believed that estrogens exert their bone sparing effects directly on the cells within the bone compartment. The aim of the present study was to investigate if central mechanisms might be involved in the bone sparing effect of estrogens. The dose-response of central (i.c.v) 17beta-estradiol (E2) administration was compared with that of peripheral (s.c.) administration in ovariectomized (ovx) mice. The dose-response curves for central and peripheral E2 administration did not differ for any of the studied estrogen-responsive tissues, indicating that these effects were mainly peripheral. In addition, ovx mice were treated with E2 and/or the peripheral estrogen receptor antagonist ICI 182,780. ICI 182,780 attenuated most of the estrogenic response regarding uterus weight, retroperitoneal fat weight, cortical BMC and trabecular bone mineral content (P<0.05). These findings support the notion that the primary target tissue that mediates the effect of E2 on bone is peripheral and not central.
|
|
| 2. |
- Andersson, Jan, et al.
(författare)
-
Trafiksäkerhetspåverkan vid omkörning av 30-metersfordon
- 2011
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Trafikverket överväger att tillåta längre och tyngre fordon på vägarna förutsatt att de inte påverkar trafiksäkerheten negativt. Syftet med studien var att undersöka säkerhetseffekten av fordonslängd, speciellt med avseende på olycksrisken vid omkörningar. Intervjuade förare av en 30-meters timmerbil hade inte upplevt de farhågor som förare av normallånga lastbilar uttryckt i samband med trånga rondeller och korsningar, men de nämner betydelsen av stödjande åkeri, arbetsmiljö och fordonsutrustning. En simulatorstudie studerade bilförares omkörningar av ett 30- och ett 18,75-metersfordon på en 2+1-väg i situationen då två körfält går ihop till ett. Tidluckan till ett återstående körfält var i genomsnitt 0,2 s (sign.) kortare efter omkörningar av 30-metersfordonet i situationer då bakänden var i samma relativa position som för 18,75-metersfordonet vid början av omkörningen. En fältstudie analyserade videoinspelade omkörningar av en 30- och en 24-meters timmerbil på en 2+1-väg och en tvåfältig väg. Ingen signifikant skillnad i tidluckor kunde påvisas mellan omkörningar av de två fordonen för någon av vägtyperna. Det senare resultatet ska dock tolkas med försiktighet på grund av ojämnt distribuerad data som insamlats under specifika förhållanden. Slutsatserna är att det finns en liten tendens till negativ säkerhetseffekt vid omkörningar av längre fordon, och att fler fältstudier är nödvändiga.
|
|
| 3. |
- Andersson, Niklas, 1970, et al.
(författare)
-
Repeated in vivo determinations of bone mineral density during parathyroid hormone treatment in ovariectomized mice.
- 2001
-
Ingår i: The Journal of endocrinology. - 0022-0795 .- 1479-6805. ; 170:3, s. 529-37
-
Tidskriftsartikel (refereegranskat)abstract
- The recent development of different genetically modified mice with potentially interesting bone phenotypes has increased the demand for effective non-invasive methods to evaluate effects on bone of mice during growth and development, and for drug evaluation. In the present study, the skeleton was analyzed by repeated in vivo scans using dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). Ovariectomized (ovx) mice treated with parathyroid hormone (PTH) were used as an animal model to evaluate these two techniques at different times after the onset of treatment. Female mice (6 weeks of age) were allocated randomly to four groups: (1) sham-operated+vehicle; (2) ovx+vehicle; (3) sham-operated+PTH(1-84) 150 microg/kg per day; (4) ovx+PTH. Six weeks after ovariectomy the drug treatment began and was continued for 8 weeks. The total body bone mineral content (BMC) and total body areal bone mineral density (BMD) were measured by DXA. Ovariectomy reduced total body BMC and total body areal BMD by 6.2+/-1.7% and 2.6+/-0.9% respectively. No effect of PTH on total body BMC was seen during the treatment period. The trabecular volumetric BMD was measured by pQCT. Ovariectomy reduced the trabecular volumetric BMD by 52+/-6.7%. The pQCT technique detected a clear effect on trabecular volumetric BMD after 2 weeks of PTH treatment (ovx 94+/-29% and sham-operated 46+/-10% more than vehicle-treated). The cortical bone was measured in a mid-diaphyseal pQCT scan of the tibia. Ovariectomy reduced the cortical BMC by 9+/-2%. PTH treatment for 8 weeks increased cortical BMC in ovx mice. In conclusion, the pQCT technique is more sensitive than the DXA technique in the detection of bone loss after ovariectomy and increased bone mass after PTH treatment in mice. Notably, the pQCT, but not the DXA, technique detected a dramatic effect as early as after 2 weeks of PTH treatment. Dynamic pQCT measurements will be useful for monitoring skeletal changes during growth and development, and for drug evaluation in mice.
|
|
| 4. |
- Andersson, Ola, 1976-, et al.
(författare)
-
Spectral shaping of DAC nonlinearity errors through modulation of expected errors
- 2001
-
Ingår i: Circuits and Systems, 2001. ISCAS 2001. The 2001 IEEE International Symposium on. - : IEEE. - 0780366859 ; , s. 417-420
-
Konferensbidrag (refereegranskat)abstract
- Traditionally, delta-sigma modulation has been used for shaping of quantization noise. We present a modified version of delta-sigma modulation which also takes into account unwanted nonlinearities by feeding back not only the quantization error, but also the expected physical error. Behavioral-level simulations of a 5th-order structure showing an improvement of up to 4 effective bits are included
|
|
| 5. |
- Lindberg, Marie K, 1975, et al.
(författare)
-
Estrogen receptor specificity for the effects of estrogen in ovariectomized mice.
- 2002
-
Ingår i: The Journal of endocrinology. - : Bioscientifica. - 0022-0795 .- 1479-6805. ; 174:2, s. 167-78
-
Tidskriftsartikel (refereegranskat)abstract
- Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both of the two estrogen receptors, were given estrogen subcutaneously (2.3 micro g/mouse per day) and the effects on different estrogen-responsive parameters, including skeletal effects, were studied. We found that estrogen increased the cortical bone dimensions in both wild-type (WT) and double ER knockout (DERKO) mice. DNA microarray analysis was performed to characterize this effect on cortical bone and it identified four genes that were regulated by estrogen in both WT and DERKO mice. The effect of estrogen on cortical bone in DERKO mice might either be due to remaining ERalpha activity or represent an ERalpha/ERbeta-independent effect. Other effects of estrogen, such as increased trabecular bone mineral density, thymic atrophy, fat reduction and increased uterine weight, were mainly ERalpha mediated.
|
|
| 6. |
- Movérare-Skrtic, Sofia, et al.
(författare)
-
Dihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized mice.
- 2006
-
Ingår i: Obesity (Silver Spring, Md.). - : Wiley. - 1930-7381 .- 1930-739X. ; 14:4, s. 662-72
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To determine the role of androgen receptor (AR) activation for adipose tissue metabolism. Sex steroids are important regulators of adipose tissue metabolism in men. Androgens may regulate the adipose tissue metabolism in men either directly by stimulation of the AR or indirectly by aromatization of androgens into estrogens and, thereafter, by stimulation of the estrogen receptors. Previous studies have shown that estrogen receptor alpha stimulation results in reduced fat mass in men. RESEARCH METHODS AND PROCEDURES: Orchidectomized mice were treated with the non-aromatizable androgen 5alpha-dihydrotestosterone (DHT), 17beta-estradiol, or vehicle. Vo(2), Vco(2), resting metabolic rate, locomotor activity, and food consumption were measured. Furthermore, changes in hepatic gene expression were analyzed. RESULTS: DHT treatment resulted in obesity, associated with reduced energy expenditure and fat oxidation. In contrast, DHT did not affect food consumption or locomotor activity. Furthermore, DHT treatment resulted in increased high-density lipoprotein-cholesterol and triglyceride levels associated with markedly decreased 7alpha-hydroxylase gene expression, indicating decreased bile acid production. DISCUSSION: We showed that AR activation results in obesity and altered lipid metabolism in orchidectomized mice. One may speculate that AR antagonists might be useful in the treatment of obesity in men.
|
|
| 7. |
- Zhang, Renyun, et al.
(författare)
-
Soap-film coating : High-speed deposition of multilayer nanofilms
- 2013
-
Ingår i: Scientific Reports. - Nature Publishing Group : Springer Science and Business Media LLC. - 2045-2322. ; 3, s. Art. no. 1477-
-
Tidskriftsartikel (refereegranskat)abstract
- The coating of thin films is applied in numerous fields and many methods are employed for the deposition of these films. Some coating techniques may deposit films at high speed; for example, ordinary printing paper is coated with micrometre-thick layers of clay at a speed of tens of meters per second. However, to coat nanometre thin films at high speed, vacuum techniques are typically required, which increases the complexity of the process. Here, we report a simple wet chemical method for the high-speed coating of films with thicknesses at the nanometre level. This soap-film coating technique is based on forcing a substrate through a soap film that contains nanomaterials. Molecules and nanomaterials can be deposited at a thickness ranging from less than a monolayer to several layers at speeds up to meters per second. We believe that the soap-film coating method is potentially important for industrial-scale nanotechnology.
|
|
| 8. |
- Andersson, Niklas, 1975-, et al.
(författare)
-
A strategy for implementing dynamic element matching in current-steering DACs
- 2000
-
Ingår i: Mixed-Signal Design, 2000. SSMSD. 2000 Southwest Symposium on. - : IEEE. - 0780359755 ; , s. 51-56
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Interesting comparisons of dynamic element matching (DEM) techniques, have been presented during the last decade. However, not many chip implementations of these DEM techniques have been presented so far. A brief review of different DEM techniques are presented in this paper together with a strategy for implementing the partial randomization DEM, PRDEM, technique in a 3.3 V supply, 14 bit CMOS current-steering wideband digital-to-analog converter (DAC)
|
|
| 9. |
- Andersson, Niklas, 1975-, et al.
(författare)
-
Comparison of Different Dynamic Element Matching Techniques for Wideband CMOS DACs
- 1999
-
Ingår i: Proceedings of the 17th Norchip Conference.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In the field of dynamic element matching, DEM, techniques, some ”new” important theoretical results have been presented during the last decade. However, no comparison between these different DEM techniques (FRDEM, PRDEM, NSDEM) used in wideband digital-to-analog converters, DACs, has been reported. A brief review of different DEM techniques and a comparison between their properties in terms of complexity, etc., are presented in this paper together with simulation results showing the impact of using different DEM techniques.
|
|
| 10. |
- Andersson, Niklas, 1975-
(författare)
-
Design of Integrated Building Blocks for the Digital/Analog Interface
- 2015
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The integrated circuit has, since it was invented in the late 1950's, undergone a tremendous development and is today found in virtually all electric equipment. The small feature size and low production cost have made it possible to implement electronics in everyday objects ranging from computers and mobile phones to smart prize tags. Integrated circuits are typically used for data communication, signal processing and data storage. Data is usually stored in digital format but signal processing can be performed both in the digital and in the analog domain. For best performance, the right partition of signal processing between the analog and digital domain must be used. This is made possible by data converters converting data between the domains. A device converting an analog signal into a digital representation is called an analog-to-digital converter (ADC) and a device converting digital data into an analog representation is called a digital-to-analog converter (DAC). In this work we present research results on these data converters and the results are compiled in three different categories. The first contribution is an error correction technique for DACs called dynamic element matching, the second contribution is a power efficient time-to-digital converter architecture and the third is a design methodology for frequency synthesis using digital oscillators.The accuracy of a data converter, i.e., how accurate data is converted, is often limited by manufacturing errors. One type of error is the so-called matching error and in this work we investigate an error correction technique for DACs called dynamic element matching (DEM). If distortion is limiting the performance of a DAC, the DEM technique increases the accuracy of the DAC by transforming the matching error from being signal dependent, which results in distortion, to become signal independent noise. This noise can then be spectrally shaped or filtered out and hereby increasing the overall resolution of the system. The DEM technique is investigated theoretically and the theory is supported by measurement results from an implemented 14-bit DAC using DEM. From the investigation it is concluded that DEM increases the performance of the DAC when matching errors are dominating but has less effect at conversion speeds when dynamic errors dominate.The next contribution is a new time-to-digital converter (TDC) architecture. A TDC is effectively an ADC converting a time difference into a digital representation. The proposed architecture allows for smaller and more power efficient data conversion than previously reported and the implemented TDC prototype is smaller and more power efficient as compared to previously published TDCs in the same performance segment.The third contribution is a design methodology for frequency synthesis using digital oscillators. Digital oscillators generate a sinusoidal output using recursive algorithms. We show that the performance of digital oscillators, in terms of amplitude and frequency stability, to a large extent depends on the start conditions of the oscillators. Further we show that by selecting the proper start condition an oscillator can be forced to repeat the same output sequence over and over again, hence we have a locked oscillator. If the oscillator is locked there is no drift in amplitude or frequency which are common problems for recursive oscillators not using this approach. To find the optimal start conditions a search algorithm has been developed which has been thoroughly tested in simulations. The digital oscillator output is used for test signal generation for a DAC or used to generate tones with high spectral purity using DACs.
|
|
