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| 2. |
- Wang, HC, et al.
(författare)
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HMG-1 as a late mediator of endotoxin lethality in mice
- 1999
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 285:5425, s. 248-251
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Tidskriftsartikel (refereegranskat)abstract
- Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia). Antagonists of TNF and IL-1 have shown limited efficacy in clinical trials, possibly because these cytokines are early mediators in pathogenesis. Here a potential late mediator of lethality is identified and characterized in a mouse model. High mobility group–1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1. Mice showed increased serum levels of HMG-1 from 8 to 32 hours after endotoxin exposure. Delayed administration of antibodies to HMG-1 attenuated endotoxin lethality in mice, and administration of HMG-1 itself was lethal. Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target.
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| 3. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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| 4. |
- Andersson, M, et al.
(författare)
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Isospin resolved double pion production at Celsius
- 1998
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Ingår i: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. - 0587-4254. ; 29:11, s. 2963-2968
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Two-pion production close to threshold has been measured in dfd and p+d reactions at CELSIUS. The results are compared to results at higher energies.
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| 5. |
- Andersson, M, et al.
(författare)
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Isospin resolved double pion production in the reaction p+d -> He-3+2 pi
- 2000
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 485:4, s. 327-333
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Tidskriftsartikel (refereegranskat)abstract
- Neutral and charged two-pion production in p + d --> He-3 + 2 pi reactions has been studied at CELSIUS at a proton beam energy of 477 MeV. The total cross section for double pion production is 0.22 +/- 0.03 mu b. The ratio of the cross sections for the pr
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| 6. |
- Andersson, M, et al.
(författare)
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Pionic fusion close to threshold: d+alpha -> Li-6*+pi(0) at CELSIUS
- 2000
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Ingår i: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. - 0587-4254. ; 31:10-11, s. 2343-2347
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Tidskriftsartikel (refereegranskat)abstract
- The isobaric analogue state of the ground state of the halo nucleus He-6 in Li-6 has been studied in a pionic fusion experiment at the CELSIUS storage ring facility in Uppsala, Sweden. The Li-6 ions were detected in a zero-degree spectrometer situated in
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| 7. |
- Andersson, M, et al.
(författare)
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Pionic fusion to a halo state, the d(alpha, Li-6*)pi(0) reaction studied close to threshold
- 2000
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 481:2-4, s. 165-170
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Tidskriftsartikel (refereegranskat)abstract
- The d(alpha,Li-6(3.56)*)pi(0) reaction has been studied at E-c.m. = 1.2 and 1.9 MeV above threshold with an alpha-particle beam incident on a deuterium cluster-jet target in CELSIUS. Complete differential cross sections were measured at both energies, int
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| 8. |
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| 9. |
- Andersson, M, et al.
(författare)
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Study of the p+d -> He-3+2 pi reaction at Celsius
- 1998
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Ingår i: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. - 0587-4254. ; 29:11, s. 2969-2971
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The exclusive p + d -->(3) He + 2 pi reaction has been studied at CELSIUS at a beam energy of 477 MeV. Preliminary results indicate that the two pions are created mainly in an isospin T = 1 state.
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| 10. |
- Andersson, M, et al.
(författare)
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The exclusive p plus d -> He-3+2 pi reaction at CELSIUS
- 2000
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Ingår i: ACTA PHYSICA POLONICA B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. ; , s. 2123-2126
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Konferensbidrag (refereegranskat)abstract
- Neutral and charged two-pion production in p + d --> He-3 --> 2 pi reactions has been studied at a proton beam energy of 477 MeV. The total cross section for double pion production is 0.22 +/- 0.03 mub. The ratio of the cross sections for the production o
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