| 1. |
- Andersson, Christian H., et al.
(författare)
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Mathematical understanding of training data and AI : a lesson plan for critical thinking and ethical perspectives
- 2024
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Ingår i: Proceedings / Actes CIEAEM 74. - Palermo, Italy. ; , s. 681-685
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Konferensbidrag (refereegranskat)abstract
- AI and machine learning are increasingly being applied to solve complex societal issues. One approach is to train algorithms on training data that describes human behavior. This is not without potential problems though. For example, historical human behavior may contain biases, and then algorithms may reproduce social injustices. This workshop contained lesson elements from a study where pre-service mathematics teachers conducted lessons to first conceptually teach how mathematical modelling based on machine learning works, and then to broaden the scope to consider critical thinking in relation to ethics and democratic values. The participants were invited to test and discuss the lesson elements.
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| 2. |
- Andersson, Malou, 1973-
(författare)
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Grov fridskränkning och grov kvinnofridskränkning : Fridskränkningsbrotten som rättslig konstruktion
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Over the last decades men’s physical and psychological violence against women in intimate relationships (domestic violence) has become a central issue in Swedish politics. Men’s physical and psychological violence against women is generally be understood as including physical, sexual and psychological violence (e.g rape, battery, sexual abuse or insults) that occurs within the family, whether or not the perpetrator shares or has shared the same residence with the woman. Law reforms have been carried through with the objective of enhancing criminal legal protection for women. In 1999, a new law came into force within the framework of chapter 4 of the Penal Code which includes any member of the family with the objective to treat acts that are already criminal from a different perspective if they are committed within a pattern of systematic physical and psychological violence.This doctoral thesis examines the concept of domestic violence and the criminal act in Chapter 4, section 4 a of the Swedish Penal Code which prescribes liability for violation of integrity offences. According to the first paragraph, a person who commits criminal acts as defined in Chapters 3, 4, 6 or 12 or of the Swedish Penal Code (e.g. rape, battery, sexual abuse or insults) or violation of a restraining order against a person with whom they have or have previously had, a close relationship will be sentenced for gross violation of integrity to imprisonment for at least nine months and at most six years if each of the acts were part of a repeated violation of the person’s integrity and the acts were liable to severely damage the person’s self-esteem. The second paragraph states if the acts were committed by a man against a woman to whom he is, or has been married or with whom he is, or has been cohabiting under circumstances comparable to marriage. He will instead be sentenced for a gross violation of a woman’s integrity to the same punishment. The objective of introducing a violation of integrity offence was to enable criminal proceedings to take in to account the abused person’s entire situation when he or she has been subjected to a series of albeit punishable but often individually relatively minor acts and to bring about an upgrading of the penal value of such acts. The main purpose of this thesis is to examine when and under which circumstances a person can be held responsible for gross violation of integrity or gross violation of a woman’s integrity. The analysis aims at the construction of the law, but also to examine the legal and social consequences and the interpretation and application of the law.
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| 3. |
- Andersson, T., et al.
(författare)
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Selective adsorption, bound states, and potential parameters for He, Ne, and Ar interacting with a Cu(110) surface
- 2006
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Ingår i: J. Chem. Phys.. - : AIP Publishing. - 0021-9606. ; 124
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Tidskriftsartikel (refereegranskat)abstract
- Using nozzle beams of He, Ne, and Ar, we have measured diffractive selective adsorption resonances from a Cu(110) surface kept at 20 K. Bound state energies of the atom-surface potentials have been determined from plots of the measured resonance energies versus incident angle and their fits to calculated kinematical dispersion relations. For 3He and 4He we have found a unique level assignment that is compatible with a single gas-surface potential curve with a well depth of 6.05 meV of the He–Cu(110) potential. This value is about 10% larger than the prediction of 5.55 meV from the current physisorption theory. The Ne and Ar data reveal a large number of closely spaced levels with level separations and estimated van der Waals coefficients that are compatible with available theoretical data.
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| 4. |
- Bombarda, F., et al.
(författare)
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Runaway electron beam control
- 2019
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 1361-6587 .- 0741-3335. ; 61:1
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Ghosheh, Nidal, 1975-, et al.
(författare)
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Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver Tissue
- 2020
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Ingår i: ACS Omega. - : American Chemical Society (ACS). - 2470-1343. ; 5:10, s. 4816-4827
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Tidskriftsartikel (refereegranskat)abstract
- Human pluripotent stem cell-derived hepatocytes (hPSC-HEP) display many properties of mature hepatocytes, including expression of important genes of the drug metabolizing machinery, glycogen storage, and production of multiple serum proteins. To this date, hPSC-HEP do not, however, fully recapitulate the complete functionality of in vivo mature hepatocytes. In this study, we applied versatile bioinformatic algorithms, including functional annotation and pathway enrichment analyses, transcription factor binding-site enrichment, and similarity and correlation analyses, to datasets collected from different stages during hPSC-HEP differentiation and compared these to developmental stages and tissues from fetal and adult human liver. Our results demonstrate a high level of similarity between the in vitro differentiation of hPSC-HEP and in vivo hepatogenesis. Importantly, the transcriptional correlation of hPSC-HEP with adult liver (AL) tissues was higher than with fetal liver (FL) tissues (0.83 and 0.70, respectively). Functional data revealed mature features of hPSC-HEP including cytochrome P450 enzymes activities and albumin secretion. Moreover, hPSC-HEP showed expression of many genes involved in drug absorption, distribution, metabolism, and excretion. Despite the high similarities observed, we identified differences of specific pathways and regulatory players by analyzing the gene expression between hPSC-HEP and AL. These findings will aid future intervention and improvement of in vitro hepatocyte differentiation protocol in order to generate hepatocytes displaying the complete functionality of mature hepatocytes. Finally, on the transcriptional level, our results show stronger correlation and higher similarity of hPSC-HEP to AL than to FL. In addition, potential targets for further functional improvement of hPSC-HEP were also identified.
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| 6. |
- Hambäck, Peter A., et al.
(författare)
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Insekter och spindlar i anlagda våtmarker : Intressanta fynd från en systematisk undersökning i Uppland och södra Halland
- 2022
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Ingår i: Entomologisk tidskrift. - 0013-886X. ; 143:1-2, s. 47-66
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Tidskriftsartikel (refereegranskat)abstract
- Wetland area has decreased dramatically compared with preindustrial times, and in manyagricultural areas almost all wetlands have been drained to gain cropland. The trend hasin recent years been reversed because society has realized the many benefits of wetlandfunctions, such as for nutrient retention and flood control. In this study we inventoried 75 wetlands in Uppland and Halland for insects and spiders with Malaise traps, pitfall traps andsuction sampling. Most included wetlands are constructed, because the main purpose was toexamine if these wetlands also can be good for arthropod diversity, but we also included somemore natural wetlands as comparison. In total, we identified more than 25,000 individualsof more than 900 species of Coleoptera, Araneae, Diptera and Heteroptera. We found onenew species for Sweden, Hilara manicata Meigen 1822, and 37 new regional records. Alarge number of species found are considered threatened or else rare. Some wetlands closeto Mälaren were particularly interesting, with three species (Hypsosinga heri (Hahn 1831),Rhaphium antennatum (Charlier 1835) and Bagous robustus Brisout de Barneville 1863)that have no records nearby during recent times. These and other species found in the studyshow that constructed wetlands can provide good habitats for arthropod biodiversity andrare species, particularly if wetland shores are grazed and trampled by cattle.
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| 7. |
- Hedman, Erik, et al.
(författare)
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Personality Change following Internet-Based Cognitive Behavior Therapy for Severe Health Anxiety
- 2014
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 9:12, s. e113871-
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Tidskriftsartikel (refereegranskat)abstract
- Personality traits have traditionally been viewed as stable, but recent studies suggest that they could be affected through psychological treatment. Internet-based cognitive behavior therapy (ICBT) for severe health anxiety (DSM-IV hypochondriasis) has been shown to be effective in reducing health anxiety, but its effect on measures of personality traits has not been investigated. The main aim of this study was to investigate the impact of ICBT on personality traits in the three broad dimensions -neuroticism, extraversion and aggression. We hypothesized that participants in ICBT would reduce their level of neuroticism compared to controls that did not receive the active treatment. No specific predictions were made regarding extraversion and aggression. Data from a randomized controlled trial were used in which participants were allocated to 12 weeks of ICBT (n=40) or to a basic attention control condition (n=41). Personality traits were assessed with the Swedish Universities Scales of Personality and the primary outcome of health anxiety was the Health Anxiety Inventory. There was a significant interaction effect of group and time on neuroticism-related scales, indicating larger pre-to post-treatment reductions in the Internet-based CBT group compared to the control condition. Analyses at 6-month follow-up showed that changes were stable. Traits relating to extraversion and aggression were largely unchanged. This study is the first to demonstrate that a brief ICBT intervention for severe health anxiety causes long-term changes in measures of personality traits related to neuroticism. The treatment thus has a broader impact than just reducing health anxiety.
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| 8. |
- Kindström Andersson, Karl, et al.
(författare)
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System of systems lessons to be learned in the development of air power for the future : a small state’s perspective
- 2022
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Sweden, as a small alliance free state with powerful neighbors, has a military history of what we nowadays call systems of systems thinking. Since the beginning of the Cold War thishas been expressed in an air force on the forefront of exploiting military innovations, not least with regard to sensor networks, datalinks, information sharing and distributed decision making. How can this history and the lessons learned come to use when future systems and technologies are to be developed to meet the uncertain future and changing threats? How does this fit with current trends such as capability-based approach and system of systemsengineering methodology? What could this mean for the development of the next generation fighter aircraft - after the Gripen E and contemporary aircraft? These questions have been studied from both a government and industry perspective, following the trend in the defense sector of a more intertwined relationship between the two, necessitated by adopting acapability view on aircraft development. This paper presents preliminary lessons identified from a case study on the project Flygvapnet 2000 (FV2000), which preceded the Net Centric Warfare era at the turn of the millennium. The analysis was based on characteristics of best practice systems of systems engineering derived from a review of literature presenting the methodology theory on capability-based approaches for analyzing, acquiring, developing, and managing military capabilities. The findings from this project will contribute to the development of systems of systems engineering methods and will spur proposals for future research.
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| 9. |
- Streng, T., et al.
(författare)
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Distribution and Function of the Hydrogen Sulfide-Sensitive TRPA1 Ion Channel in Rat Urinary Bladder
- 2008
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Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 53:2, s. 391-400
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To investigate the distribution of the transient receptor potential (TRP) A1 ion channel in the rat urinary bladder, and to study the effects of hydrogen sulfide (H2S) and known TRPA1 activators on micturition in conscious rats and on heterologously expressed ion channels. Methods: The expression of TRPA1 in urinary bladder was studied with fluorescence immunohistochemistry and real-time PCR in female Sprague-Dawley rats. Cystometric investigations were performed in conscious animals subjected to intravesical administration of sodium hydrogen sulfide (NaHS, donor of H2S), allyl isothiocyanate (AI), and cinnamaldehyde (CA). Fluorometric calcium imaging was used to study the effect of NaHS on human and mouse TRPA1 expressed in CHO cells. Results: TRPA1 immunoreactivity was found on unmyelinated nerve fibres within the urothelium, suburothelial space, and muscle layer as well as around blood vessels throughout the bladder. All TRPA1 immunoreactive nerves fibres also expressed TRPV1 immunoreactivity and vice versa. TRPA1 was also detected in urothelial cells at both transcriptional and protein levels. AI increased micturition frequency and reduced voiding volume. CA and NaHS produced similar changes in urodynamic parameters after disruption of the urothelial barrier with protamine sulfate. NaHS also induced calcium responses in TRPA1-expressing CHO cells, but not in untransfected cells. Conclusions: The expression of TRPA1 on C-fibre bladder afferents and urothelial cells together with the finding that intravesical TRPA1 activators initiate detrusor overactivity indicate that TRPA1 may have a role in sensory transduction in this organ. The study also highlights H2S as a TRPA1 activator potentially involved in inflammatory bladder disease. © 2007.
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| 10. |
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- 2018
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:9
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Tidskriftsartikel (refereegranskat)
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