| 1. |
- Andersson, L. Robin, et al.
(författare)
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Characterization of Flow Structures Induced by Highly Rough Surface Using Particle Image Velocimetry, Proper Orthogonal Decomposition and Velocity Correlations
- 2018
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Ingår i: Engineering. - : Scientific Research Publishing. - 1947-3931 .- 1947-394X. ; 10, s. 399-416
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Tidskriftsartikel (refereegranskat)abstract
- High Reynolds number flow inside a channel of rectangular cross section is examined using Particle Image Velocimetry. One wall of the channel has been replaced with a surface of a roughness representative to that of real hydropower tunnels, i.e. a random terrain with roughness dimensions typically in the range of ≈10% - 20% of the channels hydraulic radius. The rest of the channel walls can be considered smooth. The rough surface was captured from an existing blasted rock tunnel using high resolution laser scanning and scaled to 1:10. For quantification of the size of the largest flow structures, integral length scales are derived from the auto-correlation functions of the temporally averaged velocity. Additionally, Proper Orthogonal Decomposition (POD) and higher-order statistics are applied to the instantaneous snapshots of the velocity fluctuations. The results show a high spatial heterogeneity of the velocity and other flow characteristics in vicinity of the rough surface, putting outer similarity treatment into jeopardy. Roughness effects are not confined to the vicinity of the rough surface but can be seen in the outer flow throughout the channel, indicating a different behavior than postulated by Townsend’s similarity hypothesis. The effects on the flow structures vary depending on the shape and size of the roughness elements leading to a high spatial dependence of the flow above the rough surface. Hence, any spatial averaging, e.g. assuming a characteristic sand grain roughness factor, for determining local flow parameters becomes less applicable in this case.
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| 2. |
- Andersson, Robin, et al.
(författare)
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Experimental Study of Head Loss over Laser Scanned Rock Tunnel
- 2016
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Ingår i: Experimental Study of Head Loss over Laser Scanned Rock Tunnel. - Portland : Utah State University. - 9781884575754 ; , s. 22-29
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Konferensbidrag (refereegranskat)abstract
- Flow in hydropower tunnels is characterized by a high Reynolds number and often very rough rock walls. Due to the roughness of the walls, the flow in the tunnel is highly disturbed, resulting in large fluctuations of velocity and pressure in both time and space. Erosion problems and even partial collapse of tunnel walls are in some cases believed to be caused by hydraulic jacking from large flow induced pressure fluctuations. The objective of this work is to investigate the effects of the rough walls on the pressure variations in time and space over the rock surfaces. Pressure measurement experiments were performed in a 10 m long Plexiglas tunnel where one of the smooth walls was replaced with a rough surface. The rough surface was created from a down-scaled (1:10) laser scanned wall of a hydraulic tunnel. The differential pressure was measured at the smooth surface between points placed at the start and end of the first four 2 m sections of the channel. 10 gauge pressure sensors where flush mounted on the rough surface; these sensors measure the magnitude and the fluctuations of the pressure on the rough surface. The measurements showed significant spatial variation of the pressure on the surface. For example, sensors placed on protruding roughness elements showed low gauge pressure but high fluctuations. The differential pressure indicated a head loss through the tunnel that was almost four times higher than a theoretical smooth channel.
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| 5. |
- Enroth, Stefan, et al.
(författare)
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A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements
- 2012
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Ingår i: Algorithms for Molecular Biology. - : Springer Science and Business Media LLC. - 1748-7188. ; 7, s. 2-
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Tidskriftsartikel (refereegranskat)abstract
- Background: High-throughput sequencing is becoming the standard tool for investigating protein-DNA interactions or epigenetic modifications. However, the data generated will always contain noise due to e. g. repetitive regions or non-specific antibody interactions. The noise will appear in the form of a background distribution of reads that must be taken into account in the downstream analysis, for example when detecting enriched regions (peak-calling). Several reported peak-callers can take experimental measurements of background tag distribution into account when analysing a data set. Unfortunately, the background is only used to adjust peak calling and not as a preprocessing step that aims at discerning the signal from the background noise. A normalization procedure that extracts the signal of interest would be of universal use when investigating genomic patterns.Results: We formulated such a normalization method based on linear regression and made a proof-of-concept implementation in R and C++. It was tested on simulated as well as on publicly available ChIP-seq data on binding sites for two transcription factors, MAX and FOXA1 and two control samples, Input and IgG. We applied three different peak-callers to (i) raw (un-normalized) data using statistical background models and (ii) raw data with control samples as background and (iii) normalized data without additional control samples as background. The fraction of called regions containing the expected transcription factor binding motif was largest for the normalized data and evaluation with qPCR data for FOXA1 suggested higher sensitivity and specificity using normalized data over raw data with experimental background.Conclusions: The proposed method can handle several control samples allowing for correction of multiple sources of bias simultaneously. Our evaluation on both synthetic and experimental data suggests that the method is successful in removing background noise.
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| 6. |
- Hedberg, P. A. Mikael, et al.
(författare)
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Measurements and Simulations of the Flow Distribution in a Down-Scaled Multiple Outlet Spillway with Complex Channel
- 2024
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Ingår i: Water. - : Multidisciplinary Digital Publishing Institute (MDPI). - 2073-4441. ; 16:6
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of mass flow through a three-outlet spillway modeled after a scaled-down spillway were conducted. The inlet and channel leading up to the outlets were placed to lead the water toward the outlet at an angle. With this, measurements of the water level at three locations were recorded by magnetostrictive sensors. The volumetric flow rates for each individual outlet were recorded separately to study the differences between them. Additionally, Acoustic Doppler Velocimetry was used to measure water velocities close to the outlets. The conditions changed were the inlet volume flow rate and the flow distribution was measured at 90, 100, 110, and 200 L per second. Differences between the outlets were mostly within the error margin of the instruments used in the experiments with larger differences shown for the 200 L test. The results produced together with a CAD model of the setup can be used for verification of CFD methods. A simulation with the k-epsilon turbulence model is included and compared to earlier experiments and the new experimental results. Larger differences are seen in the new experiments. Differing inlet conditions are assumed as the principal cause for the differences seen.
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| 7. |
- Hedberg, P. A. Mikael, 1989-, et al.
(författare)
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Numerical modelling of flow in parallel spillways
- 2020
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Ingår i: Proceedings of the 8th IAHR International Symposium on Hydraulic Structures ISHS2020. - : The University of Queensland.
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Konferensbidrag (refereegranskat)abstract
- Mathematical modelling of single spillways is well documented in literature. For parallel spillways however, there is a lack of documented, verified, and validated cases. Here, in this article, ANSYS-CFX is used to simulate the flow over three parallel ogee-crested spillways. For mesh size verification, a grid convergence study is performed by Richardson extrapolation. The turbulence model chosen for this simulation is the k-ε model and the volume of fluid method is used to simulate the water-air interface. This article details the models ability to accurately predict flow distribution at the spillways, and the water levels. The mesh is kept relatively coarse at the channel inlet with increased mesh density at the spillways. The results are validated against experimental data from Vattenfall AB, R&Ds laboratories. The geometry and boundary conditions of the experiment are tailored for CFD. The flow rate of each spillway is measured separately with high accuracy, and for several different inlet volumetric flows. The simulation results lie within the error estimates of the measuring tools used in the experiments, within ±1%. The volume flow rate differences between the three outlets is very small, within ±1%.
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| 8. |
- Ljung, Anna-Lena, et al.
(författare)
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Modelling the Evaporation Rate in an Impingement Jet Dryer with Multiple Nozzles
- 2017
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Ingår i: International Journal of Chemical Engineering. - : Hindawi Publishing Corporation. - 1687-806X .- 1687-8078. ; 2017
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Tidskriftsartikel (refereegranskat)abstract
- Impinging jets are often used in industry to dry, cool, or heat items. In this work, a two-dimensional Computational Fluid Dynamics model is created to model an impingement jet dryer with a total of 9 pairs of nozzles that dries sheets of metal. Different methods to model the evaporation rate are studied, as well as the influence of recirculating the outlet air. For the studied conditions, the simulations show that the difference in evaporation rate between single- and two-component treatment of moist air is only around 5%, hence indicating that drying can be predicted with a simplified model where vapor is included as a nonreacting scalar. Furthermore, the humidity of the inlet air, as determined from the degree of recirculating outlet air, has a strong effect on the water evaporation rate. Results show that the metal sheet is dry at the exit if 85% of the air is recirculated, while approximately only 60% of the water has evaporated at a recirculation of 92,5%
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| 9. |
- Mikhail, Fady M., et al.
(författare)
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Overlapping phenotype of wolf-hirschhorn and beckwith-wiedemann syndromes in a girl with der(4)t(4; 1 1)(pter;pter)
- 2007
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Ingår i: American Journal of Medical Genetics, Part A. - : Wiley. - 1552-4825 .- 1552-4833. ; 143:15, s. 1760-1766
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Tidskriftsartikel (refereegranskat)abstract
- We report on an 8-month-old girl with a novel unbalanced chromosomal rearrangement, consisting of a terminal deletion of 4p and a paternal duplication of terminal 11p. Each of these is associated with the well-known clinical phenotypes of Wolf-Hirschhorn syndrome (WHS) and Beckwith-Wiedemann syndrome (BWS), respectively. She presented for clinical evaluation of dysmorphic facial features, developmental delay, atrial septal defect (ASD), and left hydro-nephrosis. High-resolution cytogenetic analysis revealed a normal female karyotype, but subtelomeric fluorescence in situ hybridization (FISH) analysis revealed a der(4)t(4;11) (pter;pter). Both FISH and microarray CGH studies clearly demonstrated that the WHS critical regions 1 and 2 were deleted, and that the BWS imprinted domains (ID) 1 and 2 were duplicated on the der(4). Parental chromosome analysis revealed that the father carried a cryptic balanced t(4;11)(pter;pter). As expected, our patient manifests findings of both WHS (a growth retardation syndrome) and BWS (an overgrowth syndrome). We compare her unique phenotypic features with those that have been reported for both syndromes.
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