| 1. |
- Andersson, Martin, et al.
(författare)
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Diversity of development paths and structural transformation in historical perspective—An introduction
- 2016
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Ingår i: Diverse Development Paths and Structural Transformation in the Escape from Poverty. - : Oxford University Press. - 9780198737407
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Bokkapitel (refereegranskat)abstract
- The chapter introduces the overriding question of the volume—whether poor countries can catch up—by providing an overview of theories and approaches that have contributed to this discussion. It argues for the importance of introducing to the analysis the role of structural transformation and to acknowledge that the conditions for economic development vary from case to case. Instead of clinging on to universal templates to be emulated for best result, the analysis of current growth processes in the developing world may be enriched if closer attention is paid to the multifaceted nature of economic backwardness and the successful pathways of catching up taking place in Asia. The chapter introduces the different contributions of the volume, situated in the borderland of Economic History and Development Economics, as pertinent examples of how the research agenda about long-term development and catching up can be enlightened.
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| 2. |
- Andersson, Martin, et al.
(författare)
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Relative economic backwardness and catching up: lessons from history, implications for development thinking
- 2016
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Ingår i: Diverse Development Paths and Structural Transformation in the Escape from Poverty. - : Oxford University Press. - 9780198737407
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Bokkapitel (refereegranskat)abstract
- This chapter expands on three main topics. First, it is argued that the economic historical perspective may contribute to our understanding of present day development processes. Instead of advocating a one-size-fits-all model, an analytical framework is offered based on common traits from diverse examples. Second, the importance of agricultural change on the road towards sustained economic growth is discussed and argued that it is a vital part of the development process. In the final section of the chapter the question is put whether in some countries perhaps the relative backwardness is too great an obstacle to permit catching up. The conclusion is that it is not too late but that the possibilities for countries today to fully take advantage of being late hinges on their ability to couple economic growth with structural transformation.
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| 3. |
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| 4. |
- Ali, Muhammad Akhtar, et al.
(författare)
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The transcriptional modulator ZBED6 regulates cell cycle and growth of human colorectal cancer cells
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The transcription factor ZBED6 is a repressor of IGF2 whose action impacts development, cell proliferation and growth in placental mammals. In human colorectal cancers, IGF2 overexpression is mutually exclusive with somatic mutations in PI3K signaling components, providing genetic evidence for a role in the PI3K pathway. To understand the role of ZBED6 in tumorigenesis, we engineered and validated somatic cell ZBED6 knock-outs in the human colorectal cancer cell lines RKO and HCT116. Transcriptome analyses revealed enrichment of cell cycle-related processes among differentially expressed genes in both cell lines. Chromatin immunoprecipitation sequencing analyses displayed enrichment of ZBED6 binding at genes upregulated in ZBED6-/- knockout clones. Ten differentially expressed genes were identified as putative direct gene targets and their downregulation by ZBED6 was experimentally validated. Eight of these genes were linked to the Wnt, Hippo, TGF-b, EGFR or PI3K pathways, all involved in colorectal cancer development. Ablation of ZBED6 affected the cell cycle and led to increased growth rate of ZBED6-/- RKO cells. These observations support a role for transcriptional modulation by ZBED6 in cell cycle regulation and growth of colorectal cancers.
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| 5. |
- Andersson, Henrik, et al.
(författare)
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Using optimization to provide decision support for strategic emergency medical service planning - Three case studies
- 2020
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Ingår i: International Journal of Medical Informatics. - : ELSEVIER IRELAND LTD. - 1386-5056 .- 1872-8243. ; 133
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Tidskriftsartikel (refereegranskat)abstract
- To achieve high performing emergency medical services (EMS), planning is of vital importance. EMS planners face several challenges when managing ambulance stations and the fleet of ambulances. In this paper, three strategic cases for EMS planners are presented together with potential solutions. In the first case, the effects of closing down a local emergency room (ER) are analyzed together with how adding an ambulance station and an ambulance to the area affected by the closing of the ER can be used to mitigate the negative consequences from the closing. The second case investigates a change in the organization of EMS. Currently, many non-urgent transport assignments are performed by ambulances which make them unavailable for more urgent calls. The potential for a more effective utilization of the ambulances is explored through transferring these assignments to designated transport vehicles. The third case is more technical and challenges the common practice regarding how time dependent demand is handled. Looking at the busiest hour or the average daily demand, is compared with taking time varying demand into account. The cases and solutions are studied using a recently developed strategic ambulance station location and ambulance allocation model for the Maximum Expected Performance Location Problem with Heterogeneous Regions (MEPLP-HR). The model has been extended to also include multiple time periods. This article demonstrates an innovative use of the model and how it can be applied to find and evaluate solutions to real cases within the field of strategic planning of EMS. The model is found to be a useful decision support tool when analyzing the cases and the expected performance of potential solutions.
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| 6. |
- Andersson, Joel B.H., et al.
(författare)
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U-Pb zircon-titanite-apatite age constraints on basin development and basin inversion in the Kiruna mining district, Sweden
- 2022
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Ingår i: Precambrian Research. - : Elsevier. - 0301-9268 .- 1872-7433. ; 372
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Tidskriftsartikel (refereegranskat)abstract
- To constrain the tectonothermal evolution of the type locality for iron oxide-apatite deposits, we have obtained U-Pb zircon, titanite, and apatite age data for the Kiruna mining district in northernmost Sweden. The results indicate that the host basin initiated in an overall extensional regime as indicated by the deposition of alluvial conglomerates and greywackes. A volcanic intercalation in a conglomerate unit northwest of the Luossavaara iron oxide-apatite deposit yields a U-Pb zircon age of 1887 ± 3 Ma representing the timing of the earliest Orosirian volcanism in the central Kiruna mining district coinciding with the onset of basin development. In-situ analysis of titanite on hydrothermally altered fracture planes within a cataclastic fault damage zone (c. 270 m from the fault core system associated to the Luossavaara iron oxide-apatite deposit) yields complex U-Pb data. Applying a strict discordance filter yields a 207Pb/206Pb age of 1889 ± 26 Ma. The age implies that the fault probably has a syn-volcanic origin and that syn-volcanic faults may have played an important role during iron ore emplacement. The mineralized basin was subsequently buried and metamorphosed under upper greenschist-facies conditions and later tectonically exhumed and cooled below the apatite closure temperature at 1805 ± 26 Ma indicated by apatite from the Nukutus iron oxide-apatite deposit. Basin inversion is temporally constrained by syn-tectonic titanite as part of sodic-calcic + Fe + Cl hydrothermal alteration along a brittle-ductile reverse shear zone to the east of the study area. Titanite grains that show sector and oscillatory zoning yield an age of 1812 ± 3 Ma, which we interpret as the onset of basin inversion. Homogeneous (relatively unzoned) titanite in the same sample yields an age of 1802 ± 8 Ma, tentatively indicating that the tectonothermal activity lasted up to c. 20 m.y.
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| 7. |
- Andersson Lassila, Andreas, et al.
(författare)
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Effects of different laser welding parameters on the joint quality for dissimilar material joints for battery applications
- 2024
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Ingår i: Optics and Laser Technology. - : Elsevier. - 0030-3992 .- 1879-2545. ; 177
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Tidskriftsartikel (refereegranskat)abstract
- For battery pack assemblies, it is crucial that the laser welded cell-to-busbar joints demonstrate both high mechanical strength and minimal electrical resistance. The present study investigates the effect of different laser welding parameters, on the mechanical strength, electrical resistance, porosity formation and joint microstructure, for dissimilar material cell-to-busbar joints. Laser welding experiments are performed, on thin nickel-plated copper and steel plates. The plates are joined in an overlap configuration, using laser beam wobbling and power modulation. Both circular and sinusoidal laser beam wobbling are used as selected strategies to increase the interface width of the joints, where also a comparison is made between the two methods. The joint quality is evaluated using joint geometry analysis, shear strength tests, computed tomography scanning and electrical resistance measurements. The results show that circular laser beam wobbling gives a larger joint shear strength compared with sinusoidal laser beam wobbling. In addition, it is observed that both the total pore volume and material mixing are significantly increased with increasing laser power and wobbling frequency for circular laser beam wobbling. However, for the sinusoidal laser beam wobbling the wobbling frequency does not show a significant impact on the total pore volume.
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| 8. |
- Andersson Lassila, Andreas, et al.
(författare)
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Numerical evaluation of cutting strategies for thin-walled parts
- 2024
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Static form errors due to in-process deflections is a major concern in flank milling of thin-walled parts. To increase both productivity and part geometric accuracy, there is a need to predict and control these form errors. In this work, a modelling framework for prediction of the cutting force-induced form errors, or thickness errors, during flank milling of a thin-walled workpiece is proposed. The modelled workpiece geometry is continuously updated to account for material removal and the reduced stiffness matrix is calculated for nodes in the engagement zone. The proposed modelling framework is able to predict the resulting thickness errors for a thin-walled plate which is cut on both sides. Several cutting strategies and cut patterns using constant z-level finishing are studied. The modelling framework is used to investigate the effect of different cut patterns, machining allowance, cutting tools and cutting parameters on the resulting thickness errors. The framework is experimentally validated for various cutting sequences and cutting parameters. The predicted thickness errors closely correspond to the experimental results. It is shown from numerical evaluations that the selection of an appropriate cut pattern is crucial in order to reduce the thickness error. Furthermore, it is shown that an increased machining allowance gives a decreased thickness error for thin-walled plates.
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