| 1. |
- Pikkemaat, Miriam, et al.
(författare)
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C-peptide predicts all-cause and cardiovascular death in a cohort of individuals with newly diagnosed type 2 diabetes. The Skaraborg diabetes register
- 2019
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Ingår i: Diabetes Research and Clinical Practice. - : Elsevier BV. - 0168-8227 .- 1872-8227. ; 150, s. 174-183
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To study the association between baseline level of C-peptide and all-cause death, cardiovascular death and cardiovascular complications among persons with newly diagnosed type 2 diabetes. Methods: The Skaraborg Diabetes Register contains data on baseline C-peptide concentrations among 398 persons <65 years with newly diagnosed type 2 diabetes 1996–1998. National registries were used to determine all-cause death, cardiovascular death and incidence of myocardial infarction and ischemic stroke until 31 December 2014. The association between baseline C-peptide and outcomes were evaluated with adjustment for multiple confounders by Cox regression analysis. Missing data were handled by multiple imputation. Results: In the imputed and fully adjusted model there was a significant association between 1 nmol/l increase in C-peptide concentration and all-cause death (HR 2.20, 95% CI 1.49–3.25, p < 0.001, number of events = 104), underlying cardiovascular death (HR 2.69, 1.49–4.85, p = 0.001, n = 35) and the composite outcome of underlying cardiovascular death, myocardial infarction or ischemic stroke (HR 1.61, 1.06–2.45, p = 0.027, n = 90). Conclusions: Elevated C-peptide levels at baseline in persons with newly diagnosed type 2 diabetes are associated with increased risk of all-cause and cardiovascular mortality. C-peptide might be used to identify persons at high risk of cardiovascular complications and premature death.
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| 2. |
- Ståhle, Alexander, et al.
(författare)
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Designguide för Smarta gator
- 2022
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Designguiden för smarta gator konkretiserar hur de fyra megatrenderna urbanisering, digitalisering, samhällsförändringar och miljöförändringar leder till nya krav och utformningsprinciper för framtidens gator. Guiden är tänkt att fungera som en inspiration och ett underlag för att förnya svensk gatupolicy på nationell, regional och kommunal nivå.Guiden innehåller utöver en inledning följande kapitel: en historisk tillbakablick (gatans utveckling), gatans användning, gatans delar, gatans design, designprocessen, guidens genomförande.
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| 3. |
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| 4. |
- Andersson Granberg, Tobias, 1973-, et al.
(författare)
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Integer Programming-Based Airspace Sectorization for Terminal Maneuvering Areas with Convex Sectors
- 2019
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Ingår i: Journal of Air Transportation. - : American Institute of Aeronautics and Astronautics. - 2380-9450. ; 27:4
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Tidskriftsartikel (refereegranskat)abstract
- In this paper an airspace sectorization framework for terminal maneuvering areas based on mixed integer programming is presented. It incorporates an airspace complexity representation, as well as various constraints on the sectors’ geometry, for example, the requirement that points demanding increased attention from air traffic controllers should lie in the sector’s interior to allow for enough time to resolve possible conflicts. The method can enforce convex sectors. In contrast to earlier integer/constraint programming approaches, which used synthesis methods with variables per elementary airspace piece that were glued together to form sectors, the integer programming formulation uses a variable per potential edge on the sector boundary. It is also the first step toward an integrated design of routes, the resulting complexity, and a sectorization. This paper presents results for Stockholm Arlanda airport and compares the integer programming results to convex sectorizations obtained by enumerating all possible topologies for a given number of sectors. This yields a proof-of-concept for the application of this highly flexible approach to terminal maneuvering areas.
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| 5. |
- Andersson, Johanna, 1984, et al.
(författare)
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Dynamics of capillary transport in semi-solid channels
- 2017
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Ingår i: Soft Matter. - 1744-683X .- 1744-6848. ; 13, s. 2562-2570
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Tidskriftsartikel (refereegranskat)abstract
- © The Royal Society of Chemistry. Capillary action has been described by Lucas and Washburn and extensively studied experimentally in hard materials, but few studies have examined capillary action in soft materials such as hydrogels. In tissue engineering, cells or dispersions must be often distributed within a hydrogel via microporous paths. Capillary action is one way to disperse such substances. Here, we examine the dynamics of capillary action in a model system of straight capillaries in two hydrogels. The channels had a circular cross-section in the micrometer size range (180-630 μm). The distance travelled over time was recorded and compared with the predictions of Lucas and Washburn. Besides water, we used a sucrose solution and a hydroxyethyl cellulose solution, both with viscosities slightly higher than that of water. The results showed that the distance travelled is proportional to the square root of time, , and that larger capillaries and lower viscosities result, as expected, in faster speeds. However, the absolute experimental values display large discrepancies from the predictions. We demonstrate that several possible reasons for these discrepancies can be ruled out and we describe a novel hypothesis for the cause of the retarded meniscus movement.
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| 8. |
- Andersson, Tobias, 1976, et al.
(författare)
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Country of birth and mortality risk in hypertension with and without diabetes: the Swedish primary care cardiovascular database.
- 2021
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Ingår i: Journal of hypertension. - 1473-5598. ; 39:6, s. 1155-1162
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Tidskriftsartikel (refereegranskat)abstract
- Hypertension and diabetes are common and are both associated with high cardiovascular morbidity and mortality. We aimed to investigate associations between mortality risk and country of birth among hypertensive individuals in primary care with and without concomitant diabetes, which has not been studied previously. In addition, we aimed to study the corresponding risks of myocardial infarction and ischemic stroke.This observational cohort study of 62557 individuals with hypertension diagnosed 2001-2008 in the Swedish Primary Care Cardiovascular Database assessed mortality by the Swedish Cause of Death Register, and myocardial infarction and ischemic stroke by the National Patient Register. Cox regression models were used to estimate study outcome hazard ratios by country of birth and time updated diabetes status, with adjustments for multiple confounders.During follow-up time without diabetes using Swedish-born as reference, adjusted mortality hazard ratios per country of birth category were Finland: 1.26 (95% confidence interval 1.15-1.38), high-income European countries: 0.84 (0.74-0.95), low-income European countries: 0.84 (0.71-1.00) and non-European countries: 0.65 (0.56-0.76). The corresponding adjusted mortality hazard ratios during follow-up time with diabetes were high-income European countries: 0.78 (0.63-0.98), low-income European countries: 0.74 (0.57-0.96) and non-European countries: 0.56 (0.44-0.71). During follow-up without diabetes, the corresponding adjusted hazard ratio of myocardial infarction was increased for Finland: 1.16 (1.01-1.34), whereas the results for ischemic stroke were inconclusive.In Sweden, hypertensive immigrants (with the exception for Finnish-born) with and without diabetes have a mortality advantage, as compared to Swedish-born.
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| 9. |
- Andersson, Tobias, 1976
(författare)
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Diabetes and hypertension - entangled chronic conditions in primary care. Time trends and determinants for mortality and cardiovascular complications.
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Diabetes and hypertension are chronic, often coexisting conditions with increased risk of premature death and cardiovascular complications. This thesis aimed to study different epidemiological aspects regarding risk of mortality and cardiovascular complications among individuals with diabetes, hypertension, and hypertension with concomitant diabetes in primary care. The thesis includes four cohort studies. In Study I, people with new-onset type 2 diabetes registered in the Skaraborg Diabetes Register (SDR) 1991–2004 were followed until 2014 to assess causes of death and mortality trends compared to controls from the population, and in Study II to evaluate C-peptide as a predictor of mortality and cardiovascular complications. In Study III, people with hypertension registered in primary care and included in the Swedish Primary Care Cardiovascular Database (SPCCD) 2001–2008 were followed until 2012 to estimate the risk of mortality and cardiovascular complications with regard to diabetes status, educational level and income, and in Study IV with regard to diabetes status and country of birth. In the SDR, excess mortality was driven by cardiovascular and endocrine causes of death and decreased by 2% per calendar year of diagnosis 1991–2004. Also, C-peptide was associated with risk of all-cause and cardiovascular mortality. In the SPCCD, diabetes and low income versus no diabetes and high income was associated with almost 4-fold increased risk of mortality and 2-fold risk of myocardial infarction and stroke. Compared to Swedish-born, Non-European country of birth was associated with decreased risk and being born in Finland with increased risk of mortality. In conclusion, excess mortality in patients in Skaraborg with type 2 diabetes has decreased. In diabetes and hypertension, socioeconomic factors and C-peptide are associated with risk of mortality and cardiovascular complications and could potentially be used to identify patients at high risk of adverse outcomes, to allocate health care resources, and to strengthen individual risk factor control with the aim to improve prognosis.
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| 10. |
- Andersson, Tobias, 1976, et al.
(författare)
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Mortality trends and cause of death in patients with new-onset type 2 diabetes and controls: A 24-year follow-up prospective cohort study.
- 2018
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Ingår i: Diabetes research and clinical practice. - : Elsevier BV. - 1872-8227 .- 0168-8227. ; 138, s. 81-89
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Tidskriftsartikel (refereegranskat)abstract
- Our aim was to assess causes of death and temporal changes in excess mortality among patients with new-onset type 2 diabetes in Skaraborg, Sweden.Patients from the Skaraborg Diabetes Register with prospectively registered new-onset type 2 diabetes 1991-2004 were included. Five individual controls matched for sex, age, geographical area and calendar year of study entry were selected using population records. Causes of deaths until 31 December 2014 were retrieved from the Cause of Death Register. Adjusted excess mortality among patients and temporal changes of excess mortality were calculated using Poisson models. Cumulative incidences of cause-specific mortality were calculated by competing risk regression.During 24years of follow-up 4364 deaths occurred among 7461 patients in 90,529 person-years (48.2/1000 person-years, 95% CI 46.8-49.7), and 18,541 deaths in 479,428 person-years among 37,271 controls (38.7/1000 person-years, 38.1-39.2). The overall adjusted mortality hazard ratio was 1.47 (p<.0001) among patients diagnosed at study start 1991 and decreased by 2% (p<.0001) per increase in calendar year of diagnosis until 2004. Excess mortality was mainly attributed to endocrine and cardiovascular cause of death with crude subdistributional hazard ratios of 5.06 (p<.001) and 1.22 (p<.001).Excess mortality for patients with new-onset type 2 diabetes was mainly attributed to deaths related to diabetes and the cardiovascular system, and decreased with increasing year of diagnosis 1991-2004. Possible explanations could be temporal trends of earlier diagnosis due to lowered diagnostic thresholds and intensified diagnostic activities, as well as improved treatment.
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