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- Arvidsson, Yvonne, 1960, et al.
(författare)
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Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract.
- 2008
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Ingår i: Endocrine-related cancer. - 1351-0088. ; 15:2, s. 569-81
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Tidskriftsartikel (refereegranskat)abstract
- We have examined the global gene expression profile of small intestinal carcinoids by microarray analysis. High expression of a number of genes was found including amyloid precursor-like protein 1 (APLP1). Quantitative real-time PCR and western blot analysis demonstrated higher expression of APLP1 in carcinoid metastases relative to primary tumours indicating a role of APLP1 in tumour dissemination. Tissue microarray analysis of gastroentero-pancreatic tumours demonstrated a high frequency of APLP1 expression and a low frequency of APLP2 expression in neuroendocrine (NE) tumours when compared with non-NE tumours at the same sites. Meta-analysis of gene expression data from a large number of tumours outside the gastrointestinal tract confirmed a correlation between APLP1 expression and NE phenotype where high expression of APLP1 was accompanied by downregulation of APLP2 in NE tumours. Cellular localization of APLP1, APLP2 and amyloid precursor protein (APP) in carcinoid cells (GOT1) by confocal microscopy demonstrated partial co-localization with synaptophysin. This suggests that the APP family of proteins is transported to the cell membrane by synaptic microvesicles and that they may influence tumour cell adhesion and invasiveness. We conclude that APLP1 is differentially upregulated in gastrointestinal NE tumours and that APLP1 may be important for the dissemination of small intestinal carcinoids. Identification of APLP1 in NE tumours offers a novel target for treatment and may also serve as a tumour-specific marker.
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| 3. |
- Cederfeldt, Marie, 1957, et al.
(författare)
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Concurrent validity of the Executive Function Performance Test in people with mild stroke
- 2011
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Ingår i: The British Journal of Occupational Therapy. - 0308-0226 .- 1477-6006. ; 74:9, s. 443-449
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Studies have shown that executive dysfunction is common in adults after stroke. Occupational therapists working in acute care assess the performance of activities of daily living; most instruments focus on personal care. However, the assessment of instrumental activities of daily living has been shown to discriminate executive dysfunction more effectively. An instrument for assessing executive dysfunction in more complex activities that is easy to handle in acute care is consequently required for clinical use. The Executive Function Performance Test (EFPT) was recently introduced into Sweden. The purpose of this study was to evaluate the concurrent validity of the EFPT in acute care for patients with mild stroke. Method: Twenty-three patients from an acute stroke unit were assessed with both the EFPT and the Assessment of Motor and Process Skills (AMPS). Results: The correlation between the EFPT and the AMPS assessments was highly significant (p = 0.003) and the concurrent validity was rho = 0.61. Conclusion: Since there is a risk that adult patients with mild stroke are discharged without rehabilitation, and there is a lack of a relevant instrument for occupational therapists that discriminates executive dysfunction in acute stroke care, the EFPT may be a suitable instrument to use with these patients.
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| 6. |
- Kadas, Krisztina, et al.
(författare)
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On the icosahedral metal-phosphorus coordination in melliniite : a gift from the sky for materials chemistry
- 2012
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Ingår i: Journal of Materials Chemistry. - : Royal Society of Chemistry (RSC). - 0959-9428 .- 1364-5501. ; 22:29, s. 14741-14745
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Tidskriftsartikel (refereegranskat)abstract
- Recently a new mineral, melliniite, was reported from a meteorite sample. This mineral has an ideal chemical composition of (Ni,Fe)(4)P and a crystal structure where the phosphorus atoms are coordinated by twelve nearest neighboring metal atoms. No other phosphide has been reported to have such high metal coordination. Therefore melliniite provides new and important information about the chemical interaction in transition metal chalcogenides and possibly pnictides. We demonstrate here, using first principles theory, that the stability and icosahedral metal-phosphorous coordination of melliniite are due to a balance between covalent Fe-P binding, configurational entropy and a weaker nickel-phosphorus binding, that has only a weak directional dependence.
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| 7. |
- Ottosson, Mikael, 1962-, et al.
(författare)
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Copper in ultrapure water, a scientific issue under debate
- 2017
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Ingår i: Corrosion Science. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0010-938X .- 1879-0496. ; 122, s. 53-60
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Tidskriftsartikel (refereegranskat)abstract
- The corrosion properties of copper in ultrapure water have been studied experimentally by submerging copper samples (99.9999%) in pure water for up to 29 months. The surface was first electropolished at ambient temperature, then exposed to hydrogen gas treatment at 300-400 degrees C, thereby reducing the bulk hydrogen content to 0.03 ppm. These copper samples, the water and the glassware were all then subjected to precise chemical analysis. Great care was taken to avoid contamination. After exposure, only similar to 6 mu g/L copper had accumulated in the water phase. Electron spectroscopy could not detect Cu2O or any other oxidation products containing copper.
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