| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
- Adolfsson, Daniel, 1992-, et al.
(författare)
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TBV Radar SLAM - Trust but Verify Loop Candidates
- 2023
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Ingår i: IEEE Robotics and Automation Letters. - : IEEE. - 2377-3766. ; 8:6, s. 3613-3620
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Tidskriftsartikel (refereegranskat)abstract
- Robust SLAM in large-scale environments requires fault resilience and awareness at multiple stages, from sensing and odometry estimation to loop closure. In this work, we present TBV (Trust But Verify) Radar SLAM, a method for radar SLAM that introspectively verifies loop closure candidates. TBV Radar SLAM achieves a high correct-loop-retrieval rate by combining multiple place-recognition techniques: tightly coupled place similarity and odometry uncertainty search, creating loop descriptors from origin-shifted scans, and delaying loop selection until after verification. Robustness to false constraints is achieved by carefully verifying and selecting the most likely ones from multiple loop constraints. Importantly, the verification and selection are carried out after registration when additional sources of loop evidence can easily be computed. We integrate our loop retrieval and verification method with a robust odometry pipeline within a pose graph framework. By evaluation on public benchmarks we found that TBV Radar SLAM achieves 65% lower error than the previous state of the art. We also show that it generalizes across environments without needing to change any parameters. We provide the open-source implementation at https://github.com/dan11003/tbv_slam_public
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| 3. |
- Andreasson, Joakim, 1973, et al.
(författare)
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A dihydroindolizine-porphyrin dyad as molecule-based all-photonic AND and NAND gates
- 2011
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Ingår i: Dyes and Pigments. - : Elsevier BV. - 0143-7208 .- 1873-3743. ; 89:3, s. 284-289
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Tidskriftsartikel (refereegranskat)abstract
- A molecular dyad consisting of a photochromic dihydroindolizine unit covalently linked to a porphyrin performs, when illuminated through a third-harmonic-generating crystal, the functions of both an AND and a NAND Boolean logic gate with shared all-optical inputs. The NAND gate is of particular interest as it is a so-called universal gate, and hence all other digital systems can be implemented by combinations of NAND gates. The functions of the AND and the NAND gates rely on changes in absorption and emission of the dyad in the visible spectral region upon isomerization of the photochromic unit. The change in absorption which forms the basis for the AND gate function is ascribed to the colorization/decolorization of the photochrome itself in response to the optical inputs. The variation in emission intensity which constitutes the NAND gate function is a result of the changes in redox properties of the photochrome that follow upon isomerization, such that only one of the two isomers is competent to quench the porphyrin emission by electron transfer.
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| 4. |
- Andréasson, Mattias
(författare)
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Peripheral neuropathy and altered cobalamin metabolism in Parkinson's disease and other movement disorders
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Peripheral neuropathy is a disorder of the peripheral nervous system (PNS) that may carry different underlying aetiologies. Studies have suggested PNS involvement may be prevalent in neurological diseases that traditionally have been regarded primarily as disorders of the central nervous system (CNS), including the neurodegenerative disorder Parkinson’s disease (PD). In PD, an increased prevalence of large and/or small fiber neuropathy has been reported. Underlying associations with biochemical signs of disturbed vitamin B12 (cobalamin) metabolism have been suggested, and proposed to be driven by chronic exposure to treatment with levodopa. However, peripheral neuropathy as an intrinsic disease feature has also been suggested, possibly driven by peripheral neurodegeneration associated with PD. We investigated the prevalence of clinical signs of peripheral neuropathy in a levodopa treated population followed at Karolinska University Hospital. Assessments included biochemical, genetic, and clinical evaluations. We observed a significantly higher prevalence of clinical signs indicative of a peripheral neuropathy, as assessed by the Utah Early Neuropathy Scale (UENS), in PD patients relative to controls. Furthermore, an association between UENS scores and plasma levels of homocysteine, an amino acid involved in the cobalamin dependent methionine cycle, was demonstrated.(Study I) In Study II we explored if Restless legs syndrome (RLS) may constitute a clinical expression of peripheral neuropathy in patients with PD and co-existent RLS. PNS assessments included both functional and structural evaluations of large and small fibers. More specifically, we employed the UENS, nerve conduction studies, quantitative sensory testing, and a novel method visualising the small fibers of the corneal subbasal nerve plexus, in vivo corneal confocal microscopy. An association between PNS assessments and the clinical expression of RLS, in the setting of PD, could not be demonstrated. This finding argues against a peripheral degenerative aetiology of RLS in this context. However, associations between PNS assessments and direct or indirect measures of disease burden in PD were demonstrated. This may possibly support the notion that PNS pathology, to some extent, could reflect ongoing CNS pathology in PD. Previous studies have highlighted a possible role of altered cobalamin metabolism also in the setting of CNS manifestations in PD. In Study IV we characterized an adult patient with PD demonstrating a rare biochemical alteration, related to the cobalamin dependent metabolic pathway that takes place in the mitochondrial compartment. We present the underlying genetic variants, including a novel variant, presumed to drive this alteration, and discuss possible clinical implications. Gaucher disease (GD) is a hereditary lysosomal storage disorder that, to some extent, shares genetic background with PD. An increased prevalence of both small and large fiber neuropathy has been associated with GD. We examined patients with GD type 1 followed at Karolinska University Hospital and patients with the Norrbottnian GD type 3 followed at Sunderby Region Hospital. We assessed symptoms and clinical signs compatible with a peripheral neuropathy, followed by electrodiagnostic testing in selected cases. Acknowledging small sample size, we believe our study may support the notion that small fiber neuropathy could represent an inherent disease feature in GD type 1, but argues against this being a prevalent finding in Norrbottnian GD type 3. We suggest that the recognition of an ongoing small fiber neuropathy in this disease may harbour treatment implications with regard to pain management.(Study III) Hereditary spastic paraparesis (HSP) constitutes a group of genetic movement disorders with vast phenotypic and genotypic hetereogeneity. We characterized the clinical phenotype, PNS involvement, and cerebrospinal fluid findings in two families with HSP-KIF5A. We confirm previous reports of inter- and intrafamilial variability of the clinical phenotype. Furthermore, we argue that elevated cerebrospinal fluid neurofilament light chain is not a mandatory finding in this upper motor neuron disease.(Study V) In conclusion, I suggest monitoring and treatment of biochemical signs of altered cobalamin metabolism in PD may serve a protective role with regard to the PNS. I speculate that PNS pathology in PD may reflect both levodopa mediated effects and manifestations inherent to the disease itself, possibly with a predilection for large and small fibers respectively. Thus, I believe future studies addressing the potential biomarker role of PNS assessments, as a surrogate marker of general disease progression in PD, are warranted. Such studies must account for the possibility of clouding effects related to altered cobalamin metabolism mediated by levodopa.
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| 5. |
- Andreasson, Mattias, et al.
(författare)
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Project Avatar Developing a Distributed Mobile Phone Game
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Team Avatar, as the members of Project Avatar have come to be known by, is a group of 4th year computer science students at Uppsala University that have been developing a distributed mobile phone game during the fall of 2005. In this paper we describe the general design and environment of the result of Project Avatar - the game Three Crowns.
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| 6. |
- Andreasson, Patrik, et al.
(författare)
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BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
- 1997
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Ingår i: Genes, Chromosomes and Cancer. - 1045-2257. ; 20:3, s. 299-304
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Tidskriftsartikel (refereegranskat)abstract
- A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as the sole chromosomal abnormality was investigated by fluorescence in situ hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML. The present case suggests that ETV6/ABL positivity may constitute a new genetic subgroup of BCR-negative CML.
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| 7. |
- Andreasson, Patrik, et al.
(författare)
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Cytogenetic and FISH studies of a single center consecutive series of 152 childhood acute lymphoblastic leukemias
- 2000
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Ingår i: European Journal of Haematology. - : Wiley. - 1600-0609 .- 0902-4441. ; 65:1, s. 40-51
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Tidskriftsartikel (refereegranskat)abstract
- Between 1977 and 1996, cytogenetic investigations were performed on 182 childhood (< or = 16 yr) acute lymphoblastic leukemias (ALL), constituting 94% (182 of 194) of all ALL patients diagnosed and treated at the Departments of Pediatrics, Lund and Malmo University Hospitals, Sweden, during these two decades. The cytogenetic analyses were successful in 152 cases (84%). The failure rate was higher for the ALL investigated before 1987 (30% vs. 4%, p < 0.0001), and also the incidence of cytogenetically normal cases was higher during 1977-86 (43% vs. 25%, p < 0.05). Clonal chromosomal abnormalities were found in 103 (68%) ALL. Structural rearrangements were detected, by chromosome banding alone, in 76 cases (50%). Fluorescence in situ hybridization (FISH) was used to identify cases with t(12;21), 11q23 rearrangements, and 9p deletions, using probes for ETV6/CBFA2, MLL, and CDKN2A/B, in 72 cases from which cells in fixative and/or unstained metaphase preparations were available. In total, the most common structural rearrangements were del(9p) (17%), t(12;21) (15%), del(6q) (8%), and MLL rearrangements (4%). Six (32%) of nineteen cytogenetically normal ALL analyzed by FISH harbored cryptic abnormalities; three displayed t(12;21) and four had del(9p), one of which also carried a t(12;21). Five (45%) of the t(12;21)-positive ALL showed +der(21)t(12;21) or ider(21)(q10)t(12;21), resulting in the formation of double fusion genes. Among the more rare aberrations, eight structural rearrangements were identified as novel recurrent ALL-associated abnormalities, and nine cases harbored rearrangements previously not reported. Sixteen cases displayed karyotypically unrelated clones at different investigations. Seven ALL (5%) showed simple chromosomal changes, unrelated to the aberrations detected at diagnosis, during morphologic and clinical remission, and in all but one instance the patients remained in remission, with the abnormal clone disappearing in subsequent investigations. This indicates that the emergence of novel clonal chromosomal aberrations during remission in childhood ALL is rather common and does not by necessity predict a forthcoming relapse.
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| 8. |
- Andreasson, Ulrika, et al.
(författare)
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Identification of molecular targets associated with transformed diffuse large B cell lymphoma using highly purified tumor cells
- 2009
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Ingår i: American Journal of Hematology. - : Wiley. - 0361-8609 .- 1096-8652. ; 84:12, s. 803-808
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Tidskriftsartikel (refereegranskat)abstract
- Follicular lymphoma (FL) frequently transforms into the more aggressive diffuse large B cell lymphoma (DLBCL-tr), but no protein biomarkers have been identified for predictive or early diagnosis. Gene expression analyses have identified genes changing on transformation but have failed to be reproducible in different studies, reflecting the heterogeneity within the tumor tissue and between tumor samples. Gene expression analyses on Affymetrix Human Genome U133 Plus 2.0 arrays were performed, using flow cytometry sorted tumor cells derived from FL and transformed DLBCL. To identify molecular targets associated with the transformation, subsequent immunohistochemistry (IHC) analyses of the corresponding proteins were performed. Using highly purified cells, this study identified 163 genes, which were significantly deregulated during the transformation in a majority of cases. Among the upregulated transcripts, 13 genes were selected for validation using IHC, based on the availability of commercial antibodies, and galectin-3 and NEK2 proteins specifically identify DLBCL-tr, when compared with FL. We demonstrate that by purifying tumor cells through cell sorting, thereby reducing the heterogeneity due to infiltrating cells, it was possible to identify distinct differences between tumor entities rather than variations due to cellular composition. Galectin-3 and NEK2 both identified a subgroup of DLBCL-tr, and the function of these protein markers also suggests a biological role in the transformation process.
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| 9. |
- Andreasson, Ulrika, et al.
(författare)
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Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples.
- 2010
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Ingår i: American Journal of Hematology. - : Wiley. - 0361-8609 .- 1096-8652. ; 85:6, s. 418-425
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Tidskriftsartikel (refereegranskat)abstract
- Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repression and transcriptional activation. Still, this information is not used for classification of B-cell lymphomas (BCLs). Traditionally, BCLs are diagnosed based on a phenotypic resemblance to normal B-cells; assessed by immunohistochemistry or flow cytometry, by using a handful of phenotypic markers. In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), providing a new powerful means for the classification, prediction of survival, and response to treatment of lymphomas. However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. In this study, global GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treatment.
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| 10. |
- Badian, Reza A., et al.
(författare)
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The pattern of the inferocentral whorl region of the corneal subbasal nerve plexus is altered with age
- 2021
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Ingår i: The Ocular Surface. - : Elsevier. - 1542-0124 .- 1937-5913. ; 22, s. 204-212
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To describe the pattern of the nerves in the inferocentral whorl region of the human corneal subbasal nerve plexus (SBNP) in health and diseases known to affect the subbasal nerves. Methods: Laser-scanning in vivo confocal microscopy (IVCM) was used to image the SBNP bilaterally in 91 healthy subjects, 39 subjects with type 2 diabetes mellitus (T2DM), and 43 subjects with Parkinsons disease (PD). Whorl regions were classified according to nerve orientation relative to age and health/disease status. Results: Of 346 examined eyes, 300 (86.7%) had an identifiable whorl pattern. In healthy subjects, a clockwise nerve orientation of the whorl was most common (67.9%), followed by non-rotatory or seam morphology (21.4%), and counterclockwise (10.7%). The clockwise orientation was more prevalent in healthy subjects than in T2DM or PD (P < 0.001). Healthy individuals below 50 years of age had a predominantly clockwise orientation (93.8%) which was reduced to 51.9% in those over 50 years (P < 0.001). Age but not disease status explained whorl orientation in T2DM and PD groups. Moreover, whorl orientation is bilaterally clockwise in the young, but adopts other orientations and becomes asymmetric across eyes with age. Finally, we report reflective dot-like features confined to the whorl region of the subbasal plexus, sometimes appearing in close association with subbasal nerves and present in 84-93% of examined eyes regardless of disease status, eye or sex. Conclusion: Subbasal nerves in the inferocentral whorl region are predominantly clockwise in young, healthy corneas. With aging and conditions of T2DM and PD, counterclockwise and non-rotatory configurations increase in prevalence, and bilateral symmetry is lost. Mechanisms regulating these changes warrant further investigation.
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