| 1. |
- Andrews, David J., et al.
(författare)
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Plasma observations during the Mars atmospheric "plume" event of March-April 2012
- 2016
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 121:4, s. 3139-3154
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Tidskriftsartikel (refereegranskat)abstract
- We present initial analyses and conclusions from plasma observations made during the reported "Mars plume event" of March-April 2012. During this period, multiple independent amateur observers detected a localized, high-altitude "plume" over the Martian dawn terminator, the cause of which remains to be explained. The estimated brightness of the plume exceeds that expected for auroral emissions, and its projected altitude greatly exceeds that at which clouds are expected to form. We report on in situ measurements of ionospheric plasma density and solar wind parameters throughout this interval made by Mars Express, obtained over the same surface region but at the opposing terminator. Measurements in the ionosphere at the corresponding location frequently show a disturbed structure, though this is not atypical for such regions with intense crustal magnetic fields. We tentatively conclude that the formation and/or transport of this plume to the altitudes where it was observed could be due in part to the result of a large interplanetary coronal mass ejection (ICME) encountering the Martian system. Interestingly, we note that the only similar plume detection in May 1997 may also have been associated with a large ICME impact at Mars.
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| 2. |
- Andrews, Lester, et al.
(författare)
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As UF3 Molecule with a Weak Triple Bond to Uranium
- 2009
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 1520-510X .- 0020-1669. ; 48:14, s. 6594-6598
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Tidskriftsartikel (refereegranskat)abstract
- After reactions of uranium atoms with NF3 and PF3 to form the N UF3 and P UF3 molecules, the analogous reaction with AsF3 produced the novel terminal arsenide As UF3. This first molecule with a uranium-arsenic bond was identified from matrix infrared spectra through comparison with spectra of the uranium nitride and phosphide species, with spectra using other metals, and with frequencies computed by density functional and multiconfigurational wave function methods. The latter calculation describes a weak triple bond to uranium in the As UF3 molecule, which has slightly less bonding and more antibonding character than the weak triple bond in P UF3.
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| 3. |
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| 4. |
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| 5. |
- Figlioli, G, et al.
(författare)
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- 2019
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Ingår i: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 5, s. 38-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.
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| 6. |
- Hall, B. E. S., et al.
(författare)
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A survey of superthermal electron flux depressions, or "electron holes," within the illuminated Martian induced magnetosphere
- 2016
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 121:5, s. 4835-4857
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Tidskriftsartikel (refereegranskat)abstract
- Since Mars lacks a global intrinsic magnetic field, the solar wind interacts directly with the Martian upper atmosphere and ionosphere. The presence of localized intense remnant crustal magnetic fields adds to this interaction, making the Martian plasma system a unique environment within the solar system. Rapid reductions in the electron flux, referred to as electron holes, occur within the Martian induced magnetosphere (IM). We present a statistical analysis of this phenomenon identified from proxy measurements of the electron flux derived from measurements by the Analyser of Space Plasmas and Energetic Neutral Atoms Electron Spectrometer experiment on board the Mars Express (MEX) spacecraft. The study is completed for the period of 9 February 2004 to 9 May 2014. Electron holes are observed within the IM in more than 56% of MEX orbits during this study period, occurring predominantly at altitudes less than 1300km, with the majority in the negative X Mars-Centric Solar Orbital direction. The spatial distribution above the surface of Mars is observed to bear close resemblance to that of the crustal magnetic fields as predicted by the Cain et al. [] magnetic field model, suggesting that they play an important role in the formation of these phenomena.
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| 7. |
- Hall, B. E. S., et al.
(författare)
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Annual variations in the Martian bow shock location as observed by the Mars Express mission
- 2016
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 121:11, s. 11474-11494
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Tidskriftsartikel (refereegranskat)abstract
- The Martian bow shock distance has previously been shown to be anticorrelated with solar wind dynamic pressure but correlated with solar extreme ultraviolet (EUV) irradiance. Since both of these solar parameters reduce with the square of the distance from the Sun, and Mars' orbit about the Sun increases by similar to 0.3 AU from perihelion to aphelion, it is not clear how the bow shock location will respond to variations in these solar parameters, if at all, throughout its orbit. In order to characterize such a response, we use more than 5 Martian years of Mars Express Analyser of Space Plasma and EneRgetic Atoms (ASPERA-3) Electron Spectrometer measurements to automatically identify 11,861 bow shock crossings. We have discovered that the bow shock distance as a function of solar longitude has a minimum of 2.39 R-M around aphelion and proceeds to a maximum of 2.65 R-M around perihelion, presenting an overall variation of similar to 11% throughout the Martian orbit. We have verified previous findings that the bow shock in southern hemisphere is on average located farther away from Mars than in the northern hemisphere. However, this hemispherical asymmetry is small (total distance variation of similar to 2.4%), and the same annual variations occur irrespective of the hemisphere. We have identified that the bow shock location is more sensitive to variations in the solar EUV irradiance than to solar wind dynamic pressure variations. We have proposed possible interaction mechanisms between the solar EUV flux and Martian plasma environment that could explain this annual variation in bow shock location.
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| 8. |
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| 9. |
- Lillis, Robert J., et al.
(författare)
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MOSAIC: A satellite constellation to enable groundbreaking mars climate system science and prepare for human exploration
- 2021
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Ingår i: Planetary Science Journal. - : Institute of Physics (IOP). - 2632-3338. ; 2:5
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Tidskriftsartikel (refereegranskat)abstract
- The Martian climate system has been revealed to rival the complexity of Earth's. Over the last 20 yr, a fragmented and incomplete picture has emerged of its structure and variability; we remain largely ignorant of many of the physical processes driving matter and energy flow between and within Mars' diverse climate domains. Mars Orbiters for Surface, Atmosphere, and Ionosphere Connections (MOSAIC) is a constellation of ten platforms focused on understanding these climate connections, with orbits and instruments tailored to observe the Martian climate system from three complementary perspectives. First, low-circular near-polar Sun-synchronous orbits (a large mothership and three smallsats spaced in local time) enable vertical profiling of wind, aerosols, water, and temperature, as well as mapping of surface and subsurface ice. Second, elliptical orbits sampling all of Mars' plasma regions enable multipoint measurements necessary to understand mass/energy transport and ion-driven escape, also enabling, with the polar orbiters, dense radio occultation coverage. Last, longitudinally spaced areostationary orbits enable synoptic views of the lower atmosphere necessary to understand global and mesoscale dynamics, global views of the hydrogen and oxygen exospheres, and upstream measurements of space weather conditions. MOSAIC will characterize climate system variability diurnally and seasonally, on meso-, regional, and global scales, targeting the shallow subsurface all the way out to the solar wind, making many first-of-their-kind measurements. Importantly, these measurements will also prepare for human exploration and habitation of Mars by providing water resource prospecting, operational forecasting of dust and radiation hazards, and ionospheric communication/positioning disruptions.
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| 10. |
- Lyon, Jonathan T., et al.
(författare)
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Infrared spectrum and bonding in uranium methylidene dihydride, CH2=UH2
- 2007
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Ingår i: Inorganic Chemistry. - : American Chemical Society (ACS). - 1520-510X .- 0020-1669. ; 46:12, s. 4917-4925
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Tidskriftsartikel (refereegranskat)abstract
- Uranium atoms activate methane upon ultraviolet excitation to form the methyl uranium hydride CH3-UH, which undergoes alpha-H transfer to produce uranium methylidene dihydride, CH2UH2. This rearrangement most likely occurs on an excited-quintet potential-energy surface and is followed by relaxation in the argon matrix. These simple U + CH4 reaction products are identified through isotopic substitution ((CH4)-C-13, CD4, CH2D2) and density functional theory frequency and structure calculations for the strong U-H stretching modes. Relativistic multiconfiguration (CASSCF/CASPT2) calculations substantiate the agostic distorted C-1 ground-state structure for the triplet CH2UH2 molecule. We find that uranium atoms are less reactive in methane activation than thorium atoms. Our calculations show that the CH2UH2 complex is distorted more than CH2ThH2. A favorable interaction between the low energy open-shell U(5f) sigma orbital and the agostic hydrogen contributes to the distortion in the uranium methylidene complexes.
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