| 1. |
- Aqueveque, Pedro, et al.
(författare)
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Antimicrobial activity of metabolites from mycelial cultures of Chilean Basidiomycetes
- 2006
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Ingår i: Journal of the Chilean Chemical Society. - 0717-9707. ; 51:4, s. 1059-1060
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Tidskriftsartikel (refereegranskat)abstract
- We reported seven compounds isolated from mycelial cultures of Chilean Basidiomycetes. The compound structures were elucidated by spectroscopic methods. Two polyacetylenes were isolated from Gymnopilus spectabilis: hepta-4,6-diyn-3-ol (1) and 7-chloro-hepta-4,6-diyn-3 ol (2). We isolated the aromatic compounds p-anisaldehyde (3) and 3-chloro-p-anisaldehyde (4) from Hypholoma capnoides. H. fasciculare produced the compounds (3), (4), 3,5-dichloro-4-metoxi-benzyl alcohol (5) and the sesquiterpen naematolon (6). Finally, H. sublateritium produced (5) and another sesquiterpen, marasmal (7). The compounds (1), (2), (5), and (7) showed biological activity against the tested model microorganism.
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| 2. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 3. |
- Gruhn, Nina, et al.
(författare)
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Biologically active metabolites from the basidiomycete Limacella illinita (Fr.) Murr.
- 2007
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Ingår i: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences. - 0939-5075. ; 62:11-12, s. 808-812
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Tidskriftsartikel (refereegranskat)abstract
- In the course of our search for new bioactive compounds from basidiomycetes, four new compounds were isolated from fermentations of Limacella illinita. Illinitone A (1) exhibited weak phytotoxic and moderate nematicidal activities against Caenorhabditis elegans, illinitone B (2) was moderately cytotoxic, while limacellone (3) exhibited weak cytotoxic and phytotoxic activities. The muurolane sesquiterpene 4a was found to be inactive in the assays performed here. Limacellone (3), which appeared to be related with the illinitones 1 and 2, has a new C-15 carbon skeleton. It is possible that compounds 1, 2 and 3 are terpenoids/secoterpenoids, but their biosyntheses were not investigated.
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| 4. |
- Kettering, Melanie, et al.
(författare)
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Antibiotics in the Chemical Communication of Fungi
- 2004
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Ingår i: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences. - 0939-5075. ; 59c:11/12, s. 816-823
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Tidskriftsartikel (refereegranskat)abstract
- In dual cultures Oudemansiella mucida and Xerula melanotricha (basidiomycetes) react to the presence of living Penicillium notatum or P. turbatum with an increased production of strobilurin A (1) or X (2). P. notatum in turn reacts to the two basidiomycetes or their antibiotic strobilurin A alone with the production of N-(2-hydroxypropanoyl)-2-aminobenzoic acid amide (3) or chrysogine (4). P. melinii and P. urticae overgrow O. mucida due to complete resistance to strobilurin A. P. brevicompactum, P. citrinum, P. janczewskii and the other Penicillium strains are all sensitive but apparently do not induce O. mucida to produce the amounts of strobilurin A needed to inhibit their growth.
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| 5. |
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| 6. |
- Meister, Janine, et al.
(författare)
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Phomopsidone, a novel depsidone from an endophyte of the medicinal plant Eupatorium arnottianum
- 2007
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Ingår i: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences. - 0939-5075. ; 62:1-2, s. 11-15
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Tidskriftsartikel (refereegranskat)abstract
- The medicinal plant Eupatorium arnottianum can be found in the Northeast and center of Argentina and the South of Bolivia. From plant material collected in Argentina an endophytic Phomopsis was isolated. The fungus was identified by microscopic features and analysis of its ITS sequence. Cultures yielded, besides mellein and nectriapyrone, a novel depsidone derivative for which we propose the name phomopsidone (1). The structure of I was determined from its spectroscopic data.
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| 7. |
- Rether, Jan, et al.
(författare)
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Imidazo[1,2-a]pyridine derivatives as inhibitors of TNF-alpha expression in T cells
- 2008
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Ingår i: Bioorganic & Medicinal Chemistry. - : Elsevier BV. - 0968-0896. ; 16:3, s. 1236-1241
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Tidskriftsartikel (refereegranskat)abstract
- Novel hexahydroimidazo[1,2-a]pyridines prepared by the addition of ethyl (1-benzylimidazolidin-2-ylidene)acetate (2) to the fungal metabolite podoscyphic acid (1a) and esters of 1a have been evaluated for their ability to inhibit the inducible TNF-α promoter activity in T cells. The methyl ester 3b is the most potent, inhibiting the TNF-α driven reporter gene expression in Jurkat T cells with an IC50-value of 2.0 μg/ml (3.6 μM). In addition, compound 3b inhibited the inducible TNF-α production in the myelomonocytic U937 cells with an IC50-value of 4.6 μM.
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| 8. |
- Schoettler, Sylvia, et al.
(författare)
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Isolation and characterization of two verrucarins from Myrothecium roridum
- 2006
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Ingår i: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences. - 0939-5075. ; 61:5-6, s. 309-314
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Tidskriftsartikel (refereegranskat)abstract
- In the course of a screening for compounds inhibiting the growth of two human breast cancer cells lines, two highly cytotoxic compounds were isolated from fermentations of Myrothecium roridum. The elucidation of their structures revealed that they are macrocyclic trichothecenes of the verrucarin type, 16-hydroxyverrucarin A (1), reported here as a natural product for the first time, and verrucarin X (2), a new compound. Both 1 and 2 exhibit moderate antifungal activity and pronounced cytotoxic activity, with IC50 values in the nanomolar (1) and micromolar (2) range. Both compounds preferentially inhibit in vivo protein biosynthesis.
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| 9. |
- Weber, Daniela, et al.
(författare)
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Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.
- 2006
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Ingår i: Journal of Antibiotics. - 0021-8820. ; 59:8, s. 495-499
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Tidskriftsartikel (refereegranskat)abstract
- In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.
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| 10. |
- Weber, Daniela, et al.
(författare)
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Mollisianitrile, a new antibiotic from Mollisia sp A59-96
- 2007
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Ingår i: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences. - 0939-5075. ; 62:7-8, s. 567-570
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Tidskriftsartikel (refereegranskat)abstract
- Mollisianitrile (1), a new antibiotic was isolated from the fermentation broth of Mollisa sp. A59-96 together with the two known isocoumarins 2 and 3. 1 exhibited antimicrobial, cytotoxic, and phytotoxic activities. 1 contains a reactive propiolonitrile moiety which is believed to be responsible for its antibiotic activities. Upon incubation with L-cysteine the biological activity was lost.
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