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- Antonoglou, Georgios N., et al.
(författare)
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Clinical Performance of Dental Implants Following Sinus Floor Augmentation : A Systematic Review and Meta-Analysis of Clinical Trials with at Least 3 Years of Follow-up
- 2018
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Ingår i: International Journal of Oral & Maxillofacial Implants. - : Quintessence. - 0882-2786 .- 1942-4434. ; 33:3, s. E45-E65
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Forskningsöversikt (refereegranskat)abstract
- Purpose: The purpose of this systematic review was to assess the survival of implants placed in augmented sinuses on a medium-to long-term basis, and identify factors affecting implant survival such as surgical technique, bone grafts, and timing of implant placement. Materials and Methods: A literature search up to July 2016 was performed to identify prospective clinical studies on sinus floor augmentation in conjunction with implant placement with a minimum follow-up of 3 years. Meta-analytic methods were implemented to calculate implant survival rates and relative risks (RR) for failure and the effect of surgical technique, use of bone graft, graft type, use of membrane, mean residual bone height, and timing of implant insertion. Results: A total of 17 clinical trials (1 randomized and 16 prospective nonrandomized) were included, which pertained to 637 patients (at least 48% male) and 1,610 implants placed after sinus floor augmentation with the osteotome (transalveolar) or lateral window approach. The pooled implant survival rate at 3 to 6 years of follow-up was 97.7% (17 studies; 95% CI = 94.4% to 99.7%) with high heterogeneity. Smoking was associated with significantly worse implant survival (2 studies; RR = 4.8; 95% CI = 1.2 to 19.4; P < .05). However, evidence of influencing factors varied from very low to moderate after adopting the GRADE approach, due to risk of bias, imprecision, inconsistency, and small-study effects. Conclusion: Current evidence suggests that implants in augmented sinuses have high survival rates, with smoking playing a potentially important negative role in their prognosis. Both indirect and direct maxillary sinus floor augmentation seem to have a low frequency of manageable complications.
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| 2. |
- Hussain, Badra, et al.
(författare)
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Peri-Implant Health and the Knowing-Doing Gap-A Digital Survey on Procedures and Therapies
- 2021
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Ingår i: FRONTIERS IN DENTAL MEDICINE. - : Frontiers Media S.A.. - 2673-4915. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Peri-implant tissue maintenance and treatment is becoming a serious challenge in implantology. With increasing numbers of implants being placed, more cases of peri-implant mucositis and peri-implantitis is seen. A digital survey on peri-implant disease management was issued to experts in periodontology and implantology to identify the tools and procedures most commonly used today to treat peri-implant diseases and successfully manage peri-implant health. The primary aim was to assess whether there is consensus in the choice of treatment to manage peri-implant diseases and to prevent their recurrence once treated. The secondary aim was to obtain insight into future protocols and /or devices, and the research and development needed.Materials and Methods: Participants in this digital survey were professionals specialising in periodontology, oral surgery, and implant dentistry. The questionnaire included both a series of closed- and open-ended questions. A total of 16 countries participated. The survey was sent by e-mail to 70 individuals, 66 received the survey and 37 of receivers responded, two of the participants were excluded due to insufficient filling of the survey. In the end 35 respondents completed the survey.Results: Respondents agree that the efficacy of mechanical and chemical decontamination of implant surfaces needs to be improved and better documented. It is a common opinion that the current remedies, mostly adapted from periodontal practises, do not provide effective and reliable clinical outcomes when treating peri-implant ailments. There is a general agreement amongst experts that regularly scheduled (3-6-month intervals) maintenance treatments are essential for maintaining peri-implant health in patients experiencing implant complications. Respondents are also concerned about unnecessary use of systemic antibiotics for managing peri-implant health.Conclusion: Regardless of agreements in parts, there was no observed consensus on the most effective treatment options for treating peri-implantitis. The experts all agree it is an urgent need for well-designed, long-term follow-up randomised and controlled clinical trials comparing interventions to provide an evidence-based strategy for peri-implant health management.
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| 3. |
- Höglund Åberg, Carola, et al.
(författare)
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Cytolethal distending toxin in isolates of Aggregatibacter actinomycetemcomitans from Ghanaian adolescents and association with serotype and disease progression
- 2013
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Ingår i: PLOS ONE. - : Public Library Science. - 1932-6203. ; 8:6, s. e65781-
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Tidskriftsartikel (refereegranskat)abstract
- Background and Objectives: The cytolethal distending toxin (Cdt) is a highly conserved exotoxin that are produced by a number of Gram negative bacteria, including Aggregatibacter actinomycetemcomitans, and affects mammalian cells by inhibiting cell division and causing apoptosis. A complete cdt-operon is present in the majority of A. actinomycetemcomitans, but the proportion of isolates that lack cdt-encoding genes (A, B and C) varies according to the population studied. The objectives of this study were to examine serotype, Cdt-genotype, and Cdt-activity in isolates of A. actinomycetemcomitans collected from an adolescent West African population and to examine the association between the carrier status of A. actinomycetemcomitans and the progression of attachment loss (AL).Material and Methods: A total of 249 A. actinomycetemcomitans isolates from 200 Ghanaian adolescents were examined for serotype and cdt-genotype by PCR. The activity of the Cdt-toxin was examined by DNA-staining of exposed cultured cells and documented with flow cytometry. The periodontal status of the participants was examined at baseline and at a two-year follow-up.Results: Presence of all three cdt-encoding genes was detected in 79% of the examined A. actinomycetemcomitans isolates. All these isolates showed a substantial Cdt-activity. The two different cdt-genotypes (with and without presence of all three cdt-encoding genes) showed a serotype-dependent distribution pattern. Presence of A. actinomycetemcomitans was significantly associated with progression of AL (OR = 5.126; 95% CI = [2.994 - 8.779], p < 0.001).Conclusion: A. actinomycetemcomitans isolated from the Ghanaian adolescents showed a distribution of serotype and cdt-genotype in line with results based on other previously studied populations. Presence of A. actinomycetemcomitans was significantly associated with disease progression, in particular the b serotype, whereas the association with disease progression was not particularly related to cdt-genotype, and Cdt-activity.
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| 4. |
- Papageorgiou, Spyridon, et al.
(författare)
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Evidence on the Association Between Periodontal Disease and General Health
- 2018
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Objectives: This umbrella review summarizes the clinical evidence across meta-analyses regarding the association between periodontitis and systemic diseases. Methods: Seven databases were searched up to January 2018 for meta-analyses of human studies on the association between periodontitis and systemic diseases. Two independent authors performed in duplicate study selection, data extraction, and methodological assessment with the AMSTAR 2 tool. Data synthesis included random-effects meta-analyses of the cumulative evidence across papers using odds ratios or relative risks with their corresponding 95% confidence intervals. The robustness of each association was assessed according to existing epidemiological criteria. Results: The literature search yielded a total of 707 papers, from which 51 unique meta-analyses were included with most of them having serious methodological weaknesses according to the AMSTAR 2 tool. A wide variety of systemic conditions were statistically significantly associated (P<0.05) with periodontitis including among other: cancers (head-neck cancer, lung cancer, pancreatic cancer, and oral cancer), cardiovascular conditions (including coronary heart disease, arterial hypertension, carotid atherosclerosis, myocardial infarction and cardiovascular mortality), chronic kidney disease, erectile dysfunction, inflammatory bowel disease, metabolic syndrome, overweight/obesity, pregnancy-related adverse outcomes (gestational diabetes, pre-eclapsia, pre-term birth, low birth weight, and pre-term low-weight birth), respiratory conditions (chronic obstructive pulmonary disease, rheumatic diseases (including rheumatoid arthritis, ankylosing spondylitis, psoriasis, and systemic lupus erythematosus), and obstructive sleep apnea, with effects ranging from 1.13 to 4.57 (Figure). However, many identified associations suffered from residual confounding, statistical heterogeneity, bias related to their basic study design, discrepancies between the disease prevalence and incidence, and small-study effects. Therefore, less than half of the identified associations between periodontitis and systemic health were supported in the end by robust epidemiological evidence. Conclusions: Periodontitis seems to be associated with many diseases, which might have important repercussions for both disease prevention and treatment. Image(s): Download Image 1 Student Presenter Disclosure Statement: The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE
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