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- Anuar, S. A., et al.
(författare)
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Effect of Carbon Supports on Oxygen Reduction Reaction of Iron/Cobalt Electrocatalyst
- 2020
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Ingår i: International Journal of Nanoelectronics and Materials. - : Unimap Press. - 1985-5761 .- 1997-4434. ; 13:Special Issue, s. 225-232
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Tidskriftsartikel (refereegranskat)abstract
- Dual metal FeCo has great potential as Pt-free catalyst in various applications, such as cathodic catalyst for fuel cells, in order to reduce the cost significantly and make fuel cell commercialization, viable. In this study, dual metal FeCo catalyst supported on carbon Vulcan XC-72, carbon nanotubes (CNT), and reduced graphene oxide (rGO) were successfully prepared via facile co-precipitation method with varying weight ratios of Fe and Co. The structure of the as-prepared catalysts was characterized by powder X-ray diffraction (XRD), scanning electron micrographs (SEM), and X-ray photoelectron spectroscopy (XPS). The XPS analysis revealed that CoFe2O4 were present on the catalyst particle surface with different Fe to Co ratio. The emergence of the new peak at 530.5 eV is assigned to the deposition of CoFe2O4, which is enabled via Fe-O-Co bonds. The FeCo/rGO catalyst with weight ratio of 2:1 exhibited the optimum performance for oxygen reduction reaction (ORR), with reduction peak of 0.163 mA cm(-2) at 0.385 V vs. Ag/AgCl in an acidic media. The experimental result suggested that the dual metal FeCo catalyst display favourable electrocatalytic activity towards ORR and appears to be a promising cathodic electrocatalyst for an acidic fuel cell.
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- Benchoula, Khaled, et al.
(författare)
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Optimization of Hyperglycemic Induction in Zebrafish and Evaluation of Its Blood Glucose Level and Metabolite Fingerprint Treated with Psychotria malayana Jack Leaf Extract
- 2019
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Ingår i: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 24:8
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Tidskriftsartikel (refereegranskat)abstract
- A standard protocol to develop type 1 diabetes in zebrafish is still uncertain due to unpredictable factors. In this study, an optimized protocol was developed and used to evaluate the anti-diabetic activity of Psychotria malayana leaf. The aims of this study were to develop a type 1 diabetic adult zebrafish model and to evaluate the anti-diabetic activity of the plant extract on the developed model. The ability of streptozotocin and alloxan at a different dose to elevate the blood glucose levels in zebrafish was evaluated. While the anti-diabetic activity of P. malayana aqueous extract was evaluated through analysis of blood glucose and LC-MS analysis fingerprinting. The results indicated that a single intraperitoneal injection of 300 mg/kg alloxan was the optimal dose to elevate the fasting blood glucose in zebrafish. Furthermore, the plant extract at 1, 2, and 3 g/kg significantly reduced blood glucose levels in the diabetic zebrafish. In addition, LC-MS-based fingerprinting indicated that 3 g/kg plant extract more effective than other doses. Phytosterols, sugar alcohols, sugar acid, free fatty acids, cyclitols, phenolics, and alkaloid were detected in the extract using GC-MS. In conclusion, P. malayana leaf aqueous extract showed anti-diabetic activity on the developed type 1 diabetic zebrafish model.
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- Heijtza, RD, et al.
(författare)
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Normal gut microbiota modulates brain development and behavior
- 2011
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 108:7, s. 3047-3052
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Tidskriftsartikel (refereegranskat)abstract
- Microbial colonization of mammals is an evolution-driven process that modulate host physiology, many of which are associated with immunity and nutrient intake. Here, we report that colonization by gut microbiota impacts mammalian brain development and subsequent adult behavior. Using measures of motor activity and anxiety-like behavior, we demonstrate that germ free (GF) mice display increased motor activity and reduced anxiety, compared with specific pathogen free (SPF) mice with a normal gut microbiota. This behavioral phenotype is associated with altered expression of genes known to be involved in second messenger pathways and synaptic long-term potentiation in brain regions implicated in motor control and anxiety-like behavior. GF mice exposed to gut microbiota early in life display similar characteristics as SPF mice, including reduced expression of PSD-95 and synaptophysin in the striatum. Hence, our results suggest that the microbial colonization process initiates signaling mechanisms that affect neuronal circuits involved in motor control and anxiety behavior.
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