| 1. |
- Franceschini, N., et al.
(författare)
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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
- 2018
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans. © 2018, The Author(s).
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| 2. |
- Franceschini, N, et al.
(författare)
-
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
- 2018
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 5141-
-
Tidskriftsartikel (refereegranskat)abstract
- Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
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| 3. |
- Kluska, J., et al.
(författare)
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VLTI images of circumbinary disks around evolved stars
- 2020
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 11446
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Konferensbidrag (refereegranskat)abstract
- The new generation of VLTI instruments (GRAVITY, MATISSE) aims to produce routinely interferometric images to uncover the morphological complexity of different objects at high angular resolution. Image reconstruction is, however, not a fully automated process. Here we focus on a specific science case, namely the complex circumbinary environments of a subset of evolved binaries, for which interferometric imaging provides the spatial resolution required to resolve the immediate circumbinary environment. Indeed, many binaries where the main star is in the post-asymptotic giant branch (post-AGB) phase are surrounded by circumbinary disks. Those disks were first inferred from the infrared excess produced by dust. Snapshot interferometric observations in the infrared confirmed disk-like morphology and revealed high spatial complexity of the emission that the use of geometrical models could not recover without being strongly biased. Arguably, the most convincing proof of the disk-like shape of the circumbinary environment came from the first interferometric image of such a system (IRAS08544-4431) using the PIONIER instrument at the VLTI. This image was obtained using the SPARCO image reconstruction approach that enables to subtract a model of a component of the image and reconstruct an image of its environment only. In the case of IRAS08544-4431, the model involved a binary and the image of the remaining signal revealed several unexpected features. Then, a second image revealed a different but also complex circumstellar morphology around HD101584 that was well studied by ALMA. To exploit the VLTI imaging capability to understand these targets, we started a large programme at the VLTI to image post-AGB binary systems using both PIONIER and GRAVITY instruments.
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