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1.	Roche, N, et al. (author) The importance of real-life research in respiratory medicine: manifesto of the Respiratory Effectiveness Group: Endorsed by the International Primary Care Respiratory Group and the World Allergy Organization 2019 In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 54:3 Journal article (other academic/artistic)
2.	Bansal, S, et al. (author) Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) triple therapy versus tiotropium monotherapy in patients with COPD 2021 In: NPJ primary care respiratory medicine. - : Springer Science and Business Media LLC. - 2055-1010. ; 31:1, s. 29- Journal article (peer-reviewed)abstract Chronic obstructive pulmonary disease (COPD) treatment guidelines do not currently include recommendations for escalation directly from monotherapy to triple therapy. This 12-week, double-blind, double-dummy study randomized 800 symptomatic moderate-to-very-severe COPD patients receiving tiotropium (TIO) for ≥3 months to once-daily fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 mcg via ELLIPTA (n = 400) or TIO 18 mcg via HandiHaler (n = 400) plus matched placebo. Study endpoints included change from baseline in trough forced expiratory volume in 1 s (FEV1) at Days 85 (primary), 28 and 84 (secondary), health status (St George’s Respiratory Questionnaire [SGRQ] and COPD Assessment Test [CAT]) and safety. FF/UMEC/VI significantly improved trough FEV1 at all timepoints (Day 85 treatment difference [95% CI] 95 mL [62–128]; P < 0.001), and significantly improved SGRQ and CAT versus TIO. Treatment safety profiles were similar. Once-daily single-inhaler FF/UMEC/VI significantly improved lung function and health status versus once-daily TIO in symptomatic moderate-to-very-severe COPD patients, with a similar safety profile.

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Anzueto, A (2); Price, D. (1); Jones, M. (1); Behr, J. (1); Brown, K. (1); Jones, R. (1); show more...; Smith, P. (1); Soriano, JB (1); Hedlin, G (1); Roberts, G (1); van Aalderen, W (1); Bousquet, J (1); Gaga, M (1); Magnussen, H (1); Papi, A (1); Demoly, P. (1); Jartti, T (1); Feleszko, W (1); Cardell, LO (1); Agache, I (1); Anderson, M. (1); van den Berge, M (1); Brusselle, G (1); Vogelmeier, C (1); Thomas, M (1); Freeman, D (1); Sliwinski, P (1); Fitzgerald, M. (1); Murray, C (1); Corbridge, TC (1); Martin, N (1); Zhu, CQ (1); Bjermer, L. (1); Usmani, O (1); Sastre, J (1); Canonica, GW (1); Makela, M (1); Roche, N (1); Mullol, J (1); Hellings, P (1); Scadding, G. (1); Fokkens, W. (1); Compton, C (1); Bansal, S (1); Brown, N (1); Erb, D (1); Harvey, C (1); Kaisermann, MC (1); Kaye, M (1); Lipson, DA (1); show less...

University: Karolinska Institutet (2)

Language: English (2)

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