| 1. |
- Arafa, Wael Abdelgayed Ahmed, et al.
(författare)
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An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives
- 2018
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Ingår i: ARKIVOC. - : Arkat. - 1551-7004 .- 1551-7012. ; , s. 338-353
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Tidskriftsartikel (refereegranskat)abstract
- An efficient, straight-forward and eco-friendly synthetic strategy for the assembly of novel bisoxazolones via a four-component, sequential reaction of dialdehydes, glycine, benzoyl chloride and acetic anhydride, using ultrasound radiation, is described. Additionally, a diverse group of new bisimidazoles has been synthesized in good yields by the sonication of diamines and (Z)-4-arylidene-2-phenyloxazol-5(4H)-ones. These approaches have resulted in a number of successful routes for the facile synthesis of bis-oxazolone and bis-imidazole frameworks within minutes of irradiation. Excellent outcomes using these environmentally-friendly parameters make these synthetic schemes ideal, sustainable, green-chemistry procedures and provide simple access towards the preparation of bisheterocycles. [GRAPHICS] .
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| 2. |
- Arafa, Wael Abdelgayed Ahmed, et al.
(författare)
-
Utilization of ultrasonic irradiation as green and effective one-pot protocol to prepare a novel series of bis-2-amino-1,3,4-oxa(thia) diazoles and bis-tetrazoles
- 2017
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Ingår i: ARKIVOC. - : ARKAT USA, Inc.. - 1551-7004 .- 1551-7012. ; , s. 327-340
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Tidskriftsartikel (refereegranskat)abstract
- In an effective and straightforward conversion, bis-semicarbazones and bis-thiosemicarbazones are transformed into a diversity of novel substituted bis-2-amino-1,3,4-oxadiazoles and bis-2-amino-1,3,4-thiadiazoles, respectively under ultrasonic irradiation. Bis-tetrazoles are obtained from the dialdehydes by sequential reaction with hydroxylamine hydrochloride, phosphorus pentoxide and sodium azide without isolation of the intermediates oximes and nitriles. All the reactions proceed cleanly and smoothly under mild conditions, with short reaction times and broad functional groups possibility. No side reactions were observed. [GRAPHICS]
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