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- Van Hoof, J., et al.
(författare)
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Light therapy : Methodological issues from an engineering perspective
- 2012
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Ingår i: Technology and Health Care. - 0928-7329 .- 1878-7401. ; 20:1, s. 11-23
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Tidskriftsartikel (refereegranskat)abstract
- Light therapy is increasingly administered and studied as a non-pharmacologic treatment for a variety of health-related problems, including treatment of people with dementia. Light therapy comes in a variety of ways, ranging from being exposed to daylight, to being exposed to light emitted by light boxes and ambient bright light. Light therapy is an area in medicine where medical sciences meet the realms of physics, engineering and technology. Therefore, it is paramount that attention is paid in the methodology of studies to the technical aspects in their full breadth. This paper provides an extensive introduction for non-technical researchers on how to describe and adjust their methodology when involved in lighting therapy research. A specific focus in this manuscript is on ambient bright light, as it is an emerging field within the domain of light therapy. The paper deals with how to (i) describe the lighting equipment, (ii) describe the light measurements, (iii) describe the building and interaction with daylight. Moreover, attention is paid to the uncertainty in standards and guidelines regarding light and lighting for older adults.
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- Arabi, A., et al.
(författare)
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Proteomic screen reveals Fbw7 as a modulator of the NF-kappa B pathway
- 2012
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 3, s. 976-
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Tidskriftsartikel (refereegranskat)abstract
- Fbw7 is a ubiquitin-ligase that targets several oncoproteins for proteolysis, but the full range of Fbw7 substrates is not known. Here we show that by performing quantitative proteomics combined with degron motif searches, we effectively screened for a more complete set of Fbw7 targets. We identify 89 putative Fbw7 substrates, including several disease-associated proteins. The transcription factor NF-κB2 (p100/p52) is one of the candidate Fbw7 substrates. We show that Fbw7 interacts with p100 via a conserved degron and that it promotes degradation of p100 in a GSK3 2 phosphorylation-dependent manner. Fbw7 inactivation increases p100 levels, which in the presence of NF-κB pathway stimuli, leads to increased p52 levels and activity. Accordingly, the apoptotic threshold can be increased by loss of Fbw7 in a p100-dependent manner. In conclusion, Fbw7-mediated destruction of p100 is a regulatory component restricting the response to NF-κB2 pathway stimulation.
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- Aries, Myriam, et al.
(författare)
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Particulate matter and the health effects on human living lung cells
- 2009
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Ingår i: 9th International Conference and Exhibition - Healthy Buildings 2009, HB 2009.
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Konferensbidrag (refereegranskat)abstract
- Predominant sources of personal particulate matter exposure are residential indoor and road-traffic or soil-borne outdoor respirable particles. Candles are an important source of indoor particulate matter. Therefore a pilot study was conducted in a specially built research facility for a fixed period of time. Fine and ultrafine particle concentrations were continuously sampled and the likelihood for potential health effects was studied using the CULTEX® system in which human lung cells were directly exposed to air samples. A high concentration of ultrafine particles was registered during the candle burning; a control condition recorded a much lower concentration and larger particle diameters. First results indicate that unhealthy situations due to candle burning in the indoor environment are very well possible.
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