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- Hoots, W. K., et al.
(författare)
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Secondary prophylaxis with recombinant activated factor VII improves health-related quality of life of haemophilia patients with inhibitors
- 2008
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 14:3, s. 466-466
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Tidskriftsartikel (refereegranskat)abstract
- Haemophilia patients with inhibitors characteristically have impaired joint function and reduced health-related quality of life (HRQoL). This analysis examined whether secondary prophylaxis with recombinant activated factor VII (rFVIIa) improves HRQoL vs. conventional on-demand therapy in patients with haemophilia with inhibitors and frequent bleeds. After a 3-month preprophylaxis period, 22 patients received daily rFVIIa prophylaxis (90 or 270 mu g kg(-1)) for 3 months, followed by 3 months' postprophylaxis. Days of hospitalization, absence from school/work and mobility aids requirements were recorded. HRQoL was assessed by EuroQoL (EQ-5D) questionnaire, visual analogue scale (VAS), derived Time to Trade-Off (TTO) scores and Quality Adjusted Life Years (QALYs). rFVIIa prophylaxis significantly (P < 0.0001) reduced bleeding frequency vs. prior on-demand therapy. Hospitalization (5.9% vs. 13.5%; P = 0.0026) and absenteeism from school/work (16.7% vs. 38.7%; P = 0.0127) decreased during prophylaxis; these effects tended to be maintained during postprophylaxis. HRQoL (evaluated by EQ-5D) tended to improve during and after rFVIIa prophylaxis. Notably, pain decreased and mobility increased in 40.9% and 27.3% of patients, respectively, at the end of the postprophylaxis period vs. preprophylaxis. Median VAS score increased from 66 to 73 (P = 0.048), and TTO scores suggested better HRQoL (0.62 vs. 0.76; P = 0.054) during postprophylaxis than preprophylaxis. Small to moderate changes in effect sizes were reported for VAS and TTO scores. Median QALYs were 0.68 (VAS) and 0.73 (TTO). Reductions in bleeding frequency with secondary rFVIIa prophylaxis were associated with improved HRQoL vs. on-demand therapy.
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| 2. |
- Arkin, Esther M., et al.
(författare)
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Fair subgraph selection for contagion containment
- 2023
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Ingår i: XII LATIN-AMERICAN ALGORITHMS, GRAPHS AND OPTIMIZATION SYMPOSIUM, LAGOS 2023. - : ELSEVIER SCIENCE BV. ; , s. 370-372
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Konferensbidrag (refereegranskat)abstract
- We present a new class of problems where the goal is to select a fair subgraph H of a given graph G = (V,E), such that H decomposes into many small components. A subgraph H subset of G is (P,d) fair if every vertex v is an element of P has the same degree d in H, where P subset of V and d > 0 are input parameters. These problems arise when the goal is to allow individuals to equally participate in activities in such a way that the connected components within an interaction graph, which models potential interactions among people, are of the smallest possible size, so that the spread of the contagion, and the difficulty of contact tracing in case of infection, is minimized. Within a preference graph that models the set of preferred choices for each individual when selecting among available options of where to conduct any particular type of activity (e.g., which gym to attend), we seek to compute the fair subgraph of assignments of individuals to these options, so that the number of people in each connected component (interaction community) of the resulting subgraph is minimized, and everyone is given the same number of options for every activity. We show that the fair subgraph selection problem is NP-hard, even for very restricted versions. We then formulate the problem as an integer program, and give a polynomial time computable lower bound on the optimal solution. (C) 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0)
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