1. |
- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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2. |
- Hibar, Derrek P., et al.
(författare)
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Novel genetic loci associated with hippocampal volume
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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3. |
- Haycock, Philip C., et al.
(författare)
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Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
- 2017
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Ingår i: JAMA Oncology. - : American Medical Association. - 2374-2437 .- 2374-2445. ; 3:5, s. 636-651
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [ 95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [ 95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [ 95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [ 95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [ 95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
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4. |
- Sampson, Joshua N., et al.
(författare)
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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
- 2015
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
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5. |
- Stewart-Koster, Ben, et al.
(författare)
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Living within the safe and just Earth system boundaries for blue water
- 2024
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Ingår i: Nature Sustainability. - 2398-9629. ; 7:1, s. 53-63
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Tidskriftsartikel (refereegranskat)abstract
- Safe and just Earth system boundaries (ESBs) for surface water and groundwater (blue water) have been defined for sustainable water management in the Anthropocene. Here we assessed whether minimum human needs could be met with surface water from within individual river basins alone and, where this is not possible, quantified how much groundwater would be required. Approximately 2.6 billion people live in river basins where groundwater is needed because they are already outside the surface water ESB or have insufficient surface water to meet human needs and the ESB. Approximately 1.4 billion people live in river basins where demand-side transformations would be required as they either exceed the surface water ESB or face a decline in groundwater recharge and cannot meet minimum needs within the ESB. A further 1.5 billion people live in river basins outside the ESB, with insufficient surface water to meet minimum needs, requiring both supply- and demand-side transformations. These results highlight the challenges and opportunities of meeting even basic human access needs to water and protecting aquatic ecosystems.
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6. |
- Abrams, Jesse F., et al.
(författare)
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Committed Global Warming Risks Triggering Multiple Climate Tipping Points
- 2023
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Ingår i: Earth's Future. - 2328-4277. ; 11:11
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Tidskriftsartikel (refereegranskat)abstract
- Many scenarios for limiting global warming to 1.5(degrees)C assume planetary-scale carbon dioxide removal sufficient to exceed anthropogenic emissions, resulting in radiative forcing falling and temperatures stabilizing. However, such removal technology may prove unfeasible for technical, environmental, political, or economic reasons, resulting in continuing greenhouse gas emissions from hard-to-mitigate sectors. This may lead to constant concentration scenarios, where net anthropogenic emissions remain non-zero but small, and are roughly balanced by natural carbon sinks. Such a situation would keep atmospheric radiative forcing roughly constant. Fixed radiative forcing creates an equilibrium committed warming, captured in the concept of equilibrium climate sensitivity. This scenario is rarely analyzed as a potential extension to transient climate scenarios. Here, we aim to understand the planetary response to such fixed concentration commitments, with an emphasis on assessing the resulting likelihood of exceeding temperature thresholds that trigger climate tipping points. We explore transients followed by respective equilibrium committed warming initiated under low to high emission scenarios. We find that the likelihood of crossing the 1.5(degrees)C threshold and the 2.0(degrees)C threshold is 83% and 55%, respectively, if today's radiative forcing is maintained until achieving equilibrium global warming. Under the scenario that best matches current national commitments (RCP4.5), we estimate that in the transient stage, two tipping points will be crossed. If radiative forcing is then held fixed after the year 2100, a further six tipping point thresholds are crossed. Achieving a trajectory similar to RCP2.6 requires reaching net-zero emissions rapidly, which would greatly reduce the likelihood of tipping events.
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7. |
- Armstrong McKay, David I., et al.
(författare)
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Exceeding 1.5°C global warming could trigger multiple climate tipping points
- 2022
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 377:6611
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Tidskriftsartikel (refereegranskat)abstract
- Climate tipping points occur when change in a part of the climate system becomes self-perpetuating beyond a warming threshold, leading to substantial Earth system impacts. Synthesizing paleoclimate, observational, and model-based studies, we provide a revised shortlist of global “core” tipping elements and regional “impact” tipping elements and their temperature thresholds. Current global warming of ~1.1°C above preindustrial temperatures already lies within the lower end of some tipping point uncertainty ranges. Several tipping points may be triggered in the Paris Agreement range of 1.5 to <2°C global warming, with many more likely at the 2 to 3°C of warming expected on current policy trajectories. This strengthens the evidence base for urgent action to mitigate climate change and to develop improved tipping point risk assessment, early warning capability, and adaptation strategies.
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8. |
- Armstrong McKay, David I., et al.
(författare)
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Reduced carbon cycle resilience across the Palaeocene-Eocene Thermal Maximum
- 2018
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Ingår i: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 14:10, s. 1515-1527
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Tidskriftsartikel (refereegranskat)abstract
- Several past episodes of rapid carbon cycle and climate change are hypothesised to be the result of the Earth system reaching a tipping point beyond which an abrupt transition to a new state occurs. At the Palaeocene-Eocene Thermal Maximum (PETM) at similar to 56 Ma and at subsequent hyperthermal events, hypothesised tipping points involve the abrupt transfer of carbon from surface reservoirs to the atmosphere. Theory suggests that tipping points in complex dynamical systems should be preceded by critical slowing down of their dynamics, including increasing temporal auto-correlation and variability. However, reliably detecting these indicators in palaeorecords is challenging, with issues of data quality, false positives, and parameter selection potentially affecting reliability. Here we show that in a sufficiently long, high-resolution palaeorecord there is consistent evidence of destabilisation of the carbon cycle in the similar to 1.5 Myr prior to the PETM, elevated carbon cycle and climate instability following both the PETM and Eocene Thermal Maximum 2 (ETM2), and different drivers of carbon cycle dynamics preceding the PETM and ETM2 events. Our results indicate a loss of resilience (weakened stabilising negative feedbacks and greater sensitivity to small shocks) in the carbon cycle before the PETM and in the carbon-climate system following it. This pre-PETM carbon cycle destabilisation may reflect gradual forcing by the contemporaneous North Atlantic Volcanic Province eruptions, with volcanism-driven warming potentially weakening the organic carbon burial feedback. Our results are consistent with but cannot prove the existence of a tipping point for abrupt carbon release, e.g. from methane hydrate or terrestrial organic carbon reservoirs, where as we find no support for a tipping point in deep ocean temperature.
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9. |
- Armstrong McKay, David I., et al.
(författare)
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Resolving ecological feedbacks on the ocean carbon sink in Earth system models
- 2021
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Ingår i: Earth System Dynamics. - : Copernicus GmbH. - 2190-4979 .- 2190-4987. ; 12:3, s. 797-818
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Tidskriftsartikel (refereegranskat)abstract
- The Earth's oceans are one of the largest sinks in the Earth system for anthropogenic CO2 emissions, acting as a negative feedback on climate change. Earth system models project that climate change will lead to a weakening ocean carbon uptake rate as warm water holds less dissolved CO2 and as biological productivity declines. However, most Earth system models do not incorporate the impact of warming on bacterial remineralisation and rely on simplified representations of plankton ecology that do not resolve the potential impact of climate change on ecosystem structure or elemental stoichiometry. Here, we use a recently developed extension of the cGEnIE (carbon-centric Grid Enabled Integrated Earth system model), ecoGEnIE, featuring a trait-based scheme for plankton ecology (ECOGEM), and also incorporate cGEnIE's temperature-dependent remineralisation (TDR) scheme. This enables evaluation of the impact of both ecological dynamics and temperature-dependent remineralisation on particulate organic carbon (POC) export in response to climate change. We find that including TDR increases cumulative POC export relative to default runs due to increased nutrient recycling (+ similar to 1.3 %), whereas ECOGEM decreases cumulative POC export by enabling a shift to smaller plankton classes (- similar to 0.9 %). However, interactions with carbonate chemistry cause opposite sign responses for the carbon sink in both cases: TDR leads to a smaller sink relative to default runs (- similar to 1.0 %), whereas ECOGEM leads to a larger sink (+ similar to 0.2 %). Combining TDR and ECOGEM results in a net strengthening of POC export (+ similar to 0.1 %) and a net reduction in carbon sink (- similar to 0.7 %) relative to default. These results illustrate the degree to which ecological dynamics and biodiversity modulate the strength of the biological pump, and demonstrate that Earth system models need to incorporate ecological complexity in order to resolve non-linear climate-biosphere feedbacks.
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10. |
- Avery, Rachael S., et al.
(författare)
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A 725-year integrated offshore terrestrial varve chronology for southeastern Sweden suggests rapid ice retreat ~ 15 ka BP
- 2021
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Ingår i: Boreas. - : Wiley. - 0300-9483 .- 1502-3885. ; 50:2, s. 477-496
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Tidskriftsartikel (refereegranskat)abstract
- The Swedish Varve Chronology is an unparalleled tool for linking the deglacial history of Sweden with associated palaeo-environmental change at an annual time scale, and it forms part of Sweden's cultural heritage. A full deglacial chronology connected to the present day does not yet exist; a notable gap is in southeasternmost Sweden, where few varved records are successfully connected to reconstruct ice-margin retreat. Deglaciation in southern Sweden covers both the climate transition to the Bølling warm period (similar to 14.7 ka BP) and the ice-margin transition from a subaqueous to terrestrial terminus. To facilitate investigations into the links between ice-margin dynamics and abrupt climate change, we revisited the varve chronologies of southern Sweden. We digitized unpublished records, reanalysed existing varve thickness records, and obtained and analysed new varve series both on land and offshore. This combined approach has enabled us to refine and extend the existing south coast chronology east and 78 km northwards. Our new Skåne-Småland chronology records 725 years of deglaciation, in addition to a younger floating chronology in parts. This chronology suggests that the glacial-lake terminating Fennoscandian Ice Sheet in southern Sweden initially retreated northwards at similar to 110-160 m a(-1) slowing to 60-70 m a(-1) near the palaeo-shoreline. Between today's mainland and the (now) island of Öland the retreat rates increase three- to fivefold. Ice-margin retreat was initially oriented towards the north (as along the south coast), but later pivoted towards the northwest, signifying a landward retreat of terrestrial 'Swedish' ice that became divorced from the Baltic Sea ice-sheet catchment. Our new 725-year-long varve thickness series reveals repeated multidecadal scale episodes of increased sedimentation. These likely signify phases of enhanced ice-sheet melting that repeat and persist throughout the deglaciation of Skåne-Småland.
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