| 1. |
- De Angeli, M., et al.
(författare)
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Cross machine investigation of magnetic tokamak dust : Morphological and elemental analysis
- 2021
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Ingår i: Fusion engineering and design. - : Elsevier BV. - 0920-3796 .- 1873-7196. ; 166
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Tidskriftsartikel (refereegranskat)abstract
- The presence of magnetic dust can be an important issue for future fusion reactors where plasma breakdown is critical. Magnetic dust has been collected from contemporary fusion devices (FTU, Alcator C-Mod, COMPASS and DIII-D) that feature different plasma facing components. The results of morphological and elemental analysis are presented. Magnetic dust is based on steel or nickel alloys and its magnetism is generated by intense plasma material interactions. In spite of the strong similarities in terms of morphology and composition, X-ray diffraction analysis revealed differences in the structural evolution that leads to non-trivial magnetic responses.
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| 2. |
- De Angeli, M., et al.
(författare)
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Cross machine investigation of magnetic tokamak dust; structural and magnetic analysis
- 2021
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Ingår i: Nuclear Materials and Energy. - : Elsevier BV. - 2352-1791. ; 28
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Tidskriftsartikel (refereegranskat)abstract
- Magnetic dust collected from multiple fusion devices (FTU, Alcator C-Mod, COMPASS) that feature different plasma-facing components (PFCs) and toroidal magnetic fields has been analyzed by means of the X-ray diffraction technique aiming to investigate the nature and origin of dust magnetism. Analysis led to the conclusion that the main mechanism of ferromagnetic dust formation is the change of iron crystalline phase from austenitic to ferritic during the re-solidification of stainless steel droplets. Analysis also revealed differences in the collected dust structure and an unexpectedly high amount of stainless steel based dust in its native austenitic phase. Theoretical estimates showed that the magnetic moment force can also mobilize strongly paramagnetic adhered dust prior to the establishment of proper tokamak discharges. The post-mortem analysis of dust collected during pure magnetic discharges in FTU confirmed these estimates.
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| 3. |
- Stuopelyte, Kristina, et al.
(författare)
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Analysis of AR-FL and AR-V1 in Whole Blood of Patients with Castration Resistant Prostate Cancer as a Tool for Predicting Response to Abiraterone Acetate
- 2020
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Ingår i: The Journal of urology. - 1527-3792. ; 204:1, s. 71-78
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Reliable molecular diagnostic tools are still unavailable for making informed treatment decisions and monitoring the response in patients with castration resistant prostate cancer. We evaluated the significance of whole blood circulating androgen receptor transcripts of full length (AR-FL) and splice variants (AR-V1, AR-V3 and AR-V7) as biomarkers of abiraterone acetate treatment resistance in patients with castration resistant prostate cancer. MATERIALS AND METHODS: After retrospective analysis in 112 prostate specimens AR-FL, AR-V1, AR-V3 and AR-V7 were evaluated in 185 serial blood samples, prospectively collected from 102 patients with castration resistant prostate cancer before and during abiraterone acetate therapy via reverse transcription quantitative polymerase chain reaction. RESULTS: AR-FL was present in all samples while AR-V1, AR-V3, AR-V7 and at least 1 of them was detected in 17%, 55%, 65% and 81% of castration resistant prostate cancer blood samples, respectively. The highest amount of AR-V1 was found in blood of patients whose response time was short and medium in comparison to extended. Patients with a higher level of AR-FL and/or AR-V1 had the shortest progression-free survival and overall survival (p <0.0001). CONCLUSIONS: Blood circulating AR-FL or AR-V1 can serve as blood based biomarkers for identification of the primary resistance to abiraterone acetate and the tool to monitor de novo resistance development during abiraterone acetate treatment.
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| 4. |
- Stuopelyte, Kristina, et al.
(författare)
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Reply by Authors
- 2020
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Ingår i: The Journal of urology. - 1527-3792. ; 204:1, s. 77-78
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Tidskriftsartikel (refereegranskat)
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