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- Arnason, T., et al.
(författare)
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Impact of temperature and growth hormone on growth physiology of juvenile Atlantic wolffish (Anarhichas lupus)
- 2019
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Ingår i: Aquaculture. - : Elsevier BV. - 0044-8486. ; 504, s. 404-413
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Tidskriftsartikel (refereegranskat)abstract
- The effects of temperature and growth hormone (GH) implantation on growth of juvenile Atlantic wolffish (Anarhichas lupus) were investigated. The year-long study had three sequential experimental phases (EP) termed EP1, EP2 and EP3, lasting for 6, 9 and 37 weeks, respectively. The experimental fish were divided into four groups and reared at different target temperatures (3, 7, 11 and 15 degrees C) during EP1 and EP2, but at a constant temperature of 7 degrees C during EP3. At the beginning of EP2, half of the fish from each group was implanted with formulation of recombinant bovine GH (Posilac (R)), while the other half was sham-implanted with vehicle. The optimal temperature for growth (T-opt.G) of early juveniles (geometric mean weight 7.5 g) was determined as 12.1 degrees C during EP1, while the upper critical temperature (Tc) was concluded to be very close to 15 degrees C, as fish at that temperature had stunted growth, increased mortality and showed external signs of skeletal deformities. Thus, the species was found to be relatively stenothermic during the early juvenile stages and therefore vulnerable to relatively modest increases in environmental temperature above T-opt.G At 15 degrees C, GH implantation had no effects on growth rate. This indicates that the high allostatic load at this temperature leaves no scope for increased growth. In contrast, at lower rearing temperatures, the GH implantation had substantial, long-term effects on growth rate and induced remarkably similar relative growth stimulation at 3, 7 and 11 degrees C, suggesting a temperature-independent mechanism for the growth-promoting effects of GH.
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| 3. |
- Arnason, T., et al.
(författare)
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Long-term rearing of Arctic charr Salvelinus alpinus under different salinity regimes at constant temperature
- 2014
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Ingår i: Journal of Fish Biology. - : Wiley. - 0022-1112. ; 85:4, s. 1145-1162
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Tidskriftsartikel (refereegranskat)abstract
- Arctic charr Salvelinus alpinus of the Holar strain (mean+/- s. e. body mass= 152.1+/-3.1g) were reared at four different salinity regimes at a constant temperature of 7.4 degrees C. Two groups were given a three-month acclimation in salinity 18 before the salinity was increased to either 25 or 29 (groups called A25 and A29), and two groups were reared in salinities 25 or 29 over the full experimental period of 409 days (groups called F25 and F29). In the first 3months, the A25 and A29 groups had the highest growth rates. By October 2011, there were no significant differences (two-way nested ANOVA, P> 0.05) in the mean body masses among A25, F25 and F29 (c. 1450 g), whereas A29 had a lower mean mass (1282 g). The growth in the last period from October 2011 to January 2012 was reduced by sexual maturation in the highest salinity regimes (A29 and F29), whereas fish in groups A25 and F25 showed high growth throughout the study. Males in all salinity groups had higher growth rates than females for the most part of the study, but the divergence between the sexes was most pronounced in the highest salinity regimes. All salinity groups showed distinct changes in Na+, K+-ATPase activity, with high activity in spring and summer, and lower activity in the autumn. Plasma sodium (Na+) levels were stable indicating that none of the experimental groups had problems in maintaining hydromineral balance during the study. While plasma leptin levels were not affected by salinity regimes, it was noted that these levels were 13-30% higher in fish with empty guts compared with those having food in their gut at the time of sampling. This suggests a link between leptin levels and food intake, indicating that this hormone may play a role in food intake and energy allocation in fishes.
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| 5. |
- Gunnarsson, S., et al.
(författare)
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Effects of short-day treatment on long-term growth performance and maturation of farmed Arctic charr Salvelinus alpinus reared in brackish water
- 2014
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Ingår i: Journal of Fish Biology. - : Wiley. - 0022-1112. ; 85:4, s. 1211-1226
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Tidskriftsartikel (refereegranskat)abstract
- The effects of a 6 week short-day photoperiod followed by continuous light, applied during the juvenile phase of Arctic charr Salvelinus alpinus in fresh water on smoltification and on the long-term growth andmaturity following transfer to brackish water (BW) (constant salinity of either 17 and 27 or increasing salinity in steps from 17 to 27) were investigated. Prior to salinity transfer, the juveniles were either reared at continuous light (C group) or reared for 6 weeks on a short day (8L: 16D, S group) followed by continuous light (24L: 0D). Increased salinity had negative effect on growth, with female fish reared at 17 salinity weighing 19 and 27% more than the salinity-step group (17-27) and the 27 salinity group, respectively. The stepwise acclimation to salinity had limited advantage in terms of growth rate. Short photoperiod for 6 weeks (November to January) followed by continuous light improved growth, but not seawater (SW) tolerance. Gill Na+, K+-ATPase activity and plasma Na+ levels changed with time, indicating some variation in osmoregulatory capacity during the experimental period. Overall, there appear to be interactive effects on maturation from applying short-day photoperiod followed by rearing at higher salinities. Plasma leptin varied with time and may be linked to stress caused by the observed variations in osmoregulatory ability. It is concluded that changes in growth rates observed in this study are mainly related to rearing salinity with higher growth rates at lower salinities. Short-day photoperiod has some growth-inducing effects but did not improve SW tolerance. Farmers of S. alpinus using BW for land-based rearing should keep salinity at moderate and stable levels according to these results to obtain best growth.
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| 8. |
- Abramson, JS, et al.
(författare)
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Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the phase 3 TRANSFORM study
- 2023
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 141:14, s. 1675-1684
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Tidskriftsartikel (refereegranskat)abstract
- This global, phase 3 study compared lisocabtagene maraleucel (liso-cel) with standard of care (SOC) as second-line therapy for primary refractory or early relapsed (≤12 months) large B-cell lymphoma (LBCL). Adults eligible for autologous stem cell transplantation (ASCT) were randomized 1:1 to liso-cel (100×106 CAR+ T cells) or SOC (3 cycles of platinum-based immunochemotherapy followed by high-dose chemotherapy and ASCT in responders). The primary end point was event-free survival (EFS) by independent review. A total of 184 patients were randomized. In this primary analysis with a median follow-up of 17.5 months, median EFS was not reached (NR) for liso-cel versus 2.4 months for SOC (hazard ratio [HR] = 0.356; 95% confidence interval [CI]: 0.243‒0.522). Complete response (CR) rate was 74% for liso-cel versus 43% for SOC (P < .0001) and median progression-free survival (PFS) was NR for liso-cel versus 6.2 months for SOC (HR = 0.400; 95% CI: 0.261‒0.615; P < .0001). Median overall survival was NR for liso-cel versus 29.9 months for SOC (HR = 0.724; 95% CI: 0.443‒1.183; P = .0987). When adjusted for crossover from SOC to liso-cel, median overall survival was NR for liso-cel and SOC (HR = 0.415; 95% CI: 0.251‒0.686). Grade 3 cytokine release syndrome and neurological events occurred in 1% and 4% of patients in the liso-cel arm, respectively (no grade 4/5 events). These data show significant improvements in EFS, CR rate, and PFS for liso-cel over SOC and support liso-cel as a preferred second-line treatment compared with SOC in patients with primary refractory or early relapsed LBCL. (ClinicalTrials.gov; NCT03575351.)
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