| 1. |
- Allard, Erik, 1976-, et al.
(författare)
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Quantitative aspects of analyzing small molecules - monitoring singly or doubly charged ions? : A case study of ximelagatran.
- 2010
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Ingår i: Rapid Communications in Mass Spectrometry. - : Wiley. - 0951-4198 .- 1097-0231. ; 24:4, s. 429-435
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Tidskriftsartikel (refereegranskat)abstract
- Precision, reproducibility and lower limit of quantitation (LLOQ) are important characteristics of a quantitative method. We have investigated these properties for Ximelagatran (Xi), which has a high tendency to form doubly charged ions in electrospray ionization (ESI), by studying the percentage of doubly charged species formed when varying the formic acid (FA) concentration, analyte concentration, amount of organic modifier and flow rate. It was found that the percentage of [Xi + 2H]2+ can be controlled to be more than 90% or less than 10% by varying the amount of FA present, and that the change between these values is dramatic. Furthermore, the percentage of [Xi + 2H]2+ formed decreases with increased analyte concentration and increased flow rate. No apparent relationship with the amount of organic modifier was found. The results have the implication that, by carefully controlling the selected parameters, the LLOQ, precision and reproducibility can be improved. We have compared the fragmentation of the singly and doubly charged species and concluded that the [Xi + 2H]2+ ion is more inclined to undergo fragmentation than [Xi + H]+. As a consequence, unusual instrumental settings had to be used for the experiments. The fragmentation patterns are to a great extent similar, but the doubly charged species is more inclined to generate low-mass product ions.
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| 2. |
- Alsarve [Arvidsson], Daniel, 1976-
(författare)
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I ständig strävan efter framgång? : föreningsdemokratins innehåll och villkor i Örebro Sportklubb 1908-89
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this dissertation is to study the conditions of and changes in sociative democracy processes at club level. One sports club is studied, Örebro Sportklubb (ÖSK), from its foundation in 1908 up to 1989. The main sources are club minutes, member magazines and annual reports. Democracy, and its twofolded relation to sport and economy processes, is the main problem area of the study. The specific question is how aspirations for economic effectiveness and sporting success influenced the democracy processes in ÖSK between 1908 and 1989.The Swedish sports movement has been described as a democratic movement. But the same movement has also been portrayed as an undemocratic movement made of men, for men. The study is based on a broad understanding of the democracy concept where issues of representativeness, influence, participation and knowledge are prominent. At a club level, the study is analysing the contents of the Swedish sports movement's democracy and its change during the 1900s. The thesis also illustrates how the pursuit of economic efficiency affected the associative democracy. These efficiencies were visible already in the 1920s, but was deepened during the 1970s. In short, the democratic range decreased, and successful sections became less and less motivated to finance the deficits of other sections.But the increased market orientation did not only represent a threat to the associative democracy. Marketisation and commercialization also preconditioned the democracy. At the club arena (Eyravallen), the members met in the clubhouse and café which, in turn, deepened the social capital and friendships within the club.
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| 3. |
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| 4. |
- Amirkhani, Ardeshir, et al.
(författare)
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Interferon-beta affects the tryptophan metabolism in multiple sclerosis patients
- 2005
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Ingår i: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 12:8, s. 625-631
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Tidskriftsartikel (refereegranskat)abstract
- Tryptophan and its metabolites are of great interest in understanding the pathogenesis of multiple sclerosis (MS). The total levels of tryptophan and its metabolites, kynurenine and kynurenic acid were determined in plasma by capillary liquid chromatography electrospray ionisation tandem mass spectrometry. This is the first report of the plasma levels of these analytes in healthy controls and relapsing-remitting MS patients receiving long-term and acute interferon-beta (IFN-beta) treatment. Twenty-four hours post-administration increased kynurenine levels (first IFN MS versus healthy, P = 0.042) and kynurenine/tryptophan ratio (K/T; first IFN MS versus healthy, P =0.027; first IFN MS versus long-term IFN MS, P = 0.036) were found. The long-term IFN MS group had higher K/T ratios at 4 and 12 h post-administration (P = 0.015 and 0.009, respectively). The increase of K/T ratio in the first IFN MS group indicate an induction of the enzyme indolamine-2,3-dioxygenase (IDO), as reported earlier in experimental allergic encephalomyelitis. As IDO is participating in both inflammatory and neurodegenerative processes, further knowledge of its involvement in the pathogenesis of MS is of great importance.
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| 5. |
- Andersson, Sara, et al.
(författare)
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Rehabilitering
- 2007
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Ingår i: Nordisk lärobok i audiologi. - Bromma : C. A. Tegnér AB. - 9789163194405 ; , s. 325-389
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Sjukdomstillstånd och skador i organ och vävnader orsakar diverse funktionella avvikelser, som i sin tur ger upphov till symptom, som personen ifråga kan iaktta och lida av. Dessa orsakar funktionsnedsättningar, som påverkar individens möjligheter att fungera och klara sig i sin dagliga miljö hemma, i olika arbetssituationer och i olika sociala sammanhang.
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| 6. |
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| 7. |
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Aquatic Conservation with Focus on Margaritifera margaritifera : Proceedings of the International Conference in Sundsvall, Sweden, 12-14 August, 2009
- 2012
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Proceedings (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- The freshwater pearl mussel Margaritifera margaritifera (L.) has attracted a large human interest, since the mussel is fascinating from biological, cultural andenvironmental perspectives. The mussel has a complicated life cycle dependingon host fish, and has great demands on its habitat. Furthermore, the mussel is anenvironmental indicator, and is used as an umbrella and flagship species. Pearl fishing has been described in Sweden as early as in the 16th century and by Carl Linnaeus in the 18th century.Many freshwater pearl mussel populations have insufficient recruitment and therefore decrease in numbers, and many populations are even extinct. Therefore, conservation work on the freshwater pearl mussel is going on all over Europe. Actions to preserve the freshwater pearl mussel will also favour other aquatic species – freshwater pearl mussel conservation is aquatic biodiversity conservation! WWF (World Wide Fund for Nature) Sweden implemented the project “The Freshwater Pearl Mussel and its habitats in Sweden” during 2004-2009 (LIFE04NAT/SE/000231). The overall objective was to improve the habitats of juvenile freshwater pearl mussels and the host fish brown trout Salmo trutta in21 streams. The actions were improvements of the biotopes, re-introduction of mussels, information to the stakeholders, and development of planning methods. An international conference “Aquatic Conservation with Focus on the Freshwater Pearl Mussel Margaritifera margaritifera” was held in Sundsvall 12–14 August, 2009. In these proceedings, presentations from the conference are published.
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| 8. |
- Ardelius, John, et al.
(författare)
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On the effects of caching in access aggregation networks
- 2012
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Ingår i: ICN 2012, Helsinki, Finland. - : Association for Computing Machinery (ACM). - 9781450314794
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Konferensbidrag (refereegranskat)abstract
- All forecasts of Internet trac point at a substantial growth over the next few years. From a network operator perspective, efficient in-network caching of data is and will be a key component in trying to cope with and profit from this increasing demand. One problem, however, is to evaluate the performance of different caching policies as the number of available data items as well as the distribution networks grows very large.In this work, we develop an analytical model of an aggregation access network receiving a continuous flow of requests from external clients. We provide exact analytical solutions for cache hit rates, data availability and more. This enables us to provide guidelines and rules of thumb for operators and Information-Centric Network designers.Finally, we apply our analytical results to a real VoD trace from a network operator and show that substantial bandwidth savings can be expected when using in-network caching in a realistic setting.
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| 9. |
- Ardelius, John, et al.
(författare)
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On the effects of caching in access aggregation networks
- 2012. - 6
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Konferensbidrag (refereegranskat)abstract
- All forecasts of Internet traffic point at a substantial growth over the next few years. From a network operator perspective, efficient in-network caching of data is and will be a key component in trying to cope with and profit from this increasing demand. One problem, however, is to evaluate the performance of different caching policies as the number of available data items as well as the distribution networks grows very large. In this work, we develop an analytical model of an aggregation access network receiving a continuous flow of requests from external clients. We provide exact analytical solutions for cache hit rates, data availability and more. This enables us to provide guidelines and rules of thumb for operators and Information-Centric Network designers. Finally, we apply our analytical results to a real VoD trace from a network operator and show that substantial bandwidth savings can be expected when using in-network caching in a realistic setting.
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| 10. |
- Arvidsson, Anna K, 1971-, et al.
(författare)
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Friktions- och texturutveckling på nya beläggningar
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- En ny vägyta bör vara och upplevas som säker av trafikanterna oavsett vilket väglag som råder. Det är därför viktigt att vägbanan har en tillfredställande nivå på friktion redan när vägen öppnas. Det finns begränsade dokumenterade kunskaper hur vägen förändras den första tiden efter en beläggningsåtgärd.Syftet med detta projekt är att fastställa hur friktionen förändras under den första tiden efter att vägbeläggningen är lagd och trafikpåsläpp sker. Ambitionen är att kunna avgöra om nylagda vägavsnitt har nedsatt friktion och ge rekommendationer för när en friktionsmätning ska utföras och hur skyltning ska ske i anslutning till beläggningsarbeten. Upplägget har varit att följa olika objekt med täta friktions- och texturmätningar från strax innan trafikpåsläpp tills nivåerna har stabiliserats.Initialt är friktionen hög för att sen avta med mängden trafik. Efter 1–3 veckor nåddes det lägsta värdet och därefter ökade eller stabiliserades friktionen. Gemensamt för alla undersökta sträckor var att det sker stora förändringar i texturnivåerna från att det första fordonet trafikerar vägen och därefter är den starkaste tendensen en sjunkande texturnivå tills en stabil nivå uppnås efter 1–3 veckor.
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