| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Abdulla, Maysaa, et al.
(författare)
-
Cell-of-origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B-cell lymphoma
- 2020
-
Ingår i: American Journal of Hematology. - : Wiley. - 0361-8609 .- 1096-8652. ; 95:1, s. 57-67
-
Tidskriftsartikel (refereegranskat)abstract
- The tumor cells in diffuse large B-cell lymphomas (DLBCL) are considered to originate from germinal center derived B-cells (GCB) or activated B-cells (ABC). Gene expression profiling (GEP) is preferably used to determine the cell of origin (COO). However, GEP is not widely applied in clinical practice and consequently, several algorithms based on immunohistochemistry (IHC) have been developed. Our aim was to evaluate the concordance of COO assignment between the Lymph2Cx GEP assay and the IHC-based Hans algorithm, to decide which model is the best survival predictor. Both GEP and IHC were performed in 359 homogenously treated Swedish and Danish DLBCL patients, in a retrospective multicenter cohort. The overall concordance between GEP and IHC algorithm was 72%; GEP classified 85% of cases assigned as GCB by IHC, as GCB, while 58% classified as non-GCB by IHC, were categorized as ABC by GEP. There were significant survival differences (overall survival and progression-free survival) if cases were classified by GEP, whereas if cases were categorized by IHC only progression-free survival differed significantly. Importantly, patients assigned as non-GCB/ABC both by IHC and GEP had the worst prognosis, which was also significant in multivariate analyses. Double expression of MYC and BCL2 was more common in ABC cases and was associated with a dismal outcome. In conclusion, to determine COO both by IHC and GEP is the strongest outcome predictor to identify DLBCL patients with the worst outcome.
|
|
| 6. |
|
|
| 7. |
- Niazi Ardekani, Mehdi, 1990-, et al.
(författare)
-
Numerical study of heat transfer in laminar and turbulent pipe flow with finite-size spherical particles
- 2018
-
Ingår i: International Journal of Heat and Fluid Flow. - : Elsevier. - 0142-727X .- 1879-2278. ; 71, s. 189-199
-
Tidskriftsartikel (refereegranskat)abstract
- Controlling heat and mass transfer in particulate suspensions has many applications in fuel combustion, food industry, pollution control and life science. We perform direct numerical simulations (DNS) to study the heat transfer within a suspension of neutrally buoyant, finite-size spherical particles in laminar and turbulent pipe flows, using the immersed boundary method (IBM) to account for the solid fluid interactions and a volume of fluid (VoF) method to resolve the temperature equation both inside and outside the particles. Particle volume fractions up to 40% are simulated for different pipe to particle diameter ratios. We show that a considerable heat transfer enhancement (up to 330%) can be achieved in the laminar regime by adding spherical particles. The heat transfer is observed to increase significantly as the pipe to particle diameter ratio decreases for the parameter range considered here. Larger particles are found to have a greater impact on the heat transfer enhancement than on the wall-drag increase. In the turbulent regime, however, only a transient increase in the heat transfer is observed and the process decelerates in time below the values in single-phase flows as high volume fractions of particles laminarize the core region of the pipe. A heat transfer enhancement, measured with respect to the single phase flow, is only achieved at volume fractions as low as 5% in a turbulent flow.
|
|
| 8. |
|
|
| 9. |
|
|
