| 1. |
- Kanfer, G, et al.
(författare)
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Mitotic redistribution of the mitochondrial network by Miro and Cenp-F
- 2015
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6, s. 8015-
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Tidskriftsartikel (refereegranskat)abstract
- Although chromosome partitioning during mitosis is well studied, the molecular mechanisms that allow proper segregation of cytoplasmic organelles in human cells are poorly understood. Here we show that mitochondria interact with growing microtubule tips and are transported towards the daughter cell periphery at the end of mitosis. This phenomenon is promoted by the direct and cell cycle-dependent interaction of the mitochondrial protein Miro and the cytoskeletal-associated protein Cenp-F. Cenp-F is recruited to mitochondria by Miro at the time of cytokinesis and associates with microtubule growing tips. Cells devoid of Cenp-F or Miro show decreased spreading of the mitochondrial network as well as cytokinesis-specific defects in mitochondrial transport towards the cell periphery. Thus, Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.
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| 2. |
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| 3. |
- Luthje, P, et al.
(författare)
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Estrogen supports urothelial defense mechanisms
- 2013
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Ingår i: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 5:190, s. 190ra80-
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Tidskriftsartikel (refereegranskat)abstract
- Estrogen supports urothelial defense against infection by increasing the expression of antimicrobial peptides and by protecting epithelial integrity.
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| 4. |
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| 5. |
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| 6. |
- Aspenstrom, P
(författare)
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Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics and membrane trafficking
- 2014
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Ingår i: Biological chemistry. - : Walter de Gruyter GmbH. - 1437-4315 .- 1431-6730. ; 395:5, s. 477-484
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Tidskriftsartikel (refereegranskat)abstract
- The Rho GTPases are essential regulators of basic cellular processes, including cell migration, cell contraction and cell division. Most studies still involve just the three canonical members, RhoA, Rac1 and Cdc42, although the Rho GTPases comprise at least 20 members. The aim of this review is to highlight some of the recent advances in our knowledge regarding the less-studied Rho members, with the focus on RhoD and Rif. The phenotypic alterations to cell behaviour that are triggered by RhoD and Rif suggest that they have unique impacts on cytoskeletal dynamics that distinguish them from the well-studied members of the Rho GTPases. In addition, RhoD has a role in the regulation of intracellular transport of vesicles. Taken together, the available data indicate that RhoD and Rif have functions as master regulators in the integration of cytoskeletal reorganisation and membrane trafficking.
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| 7. |
- Aspenstrom, P, et al.
(författare)
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BAR Domain Proteins Regulate Rho GTPase Signaling
- 2019
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Ingår i: Advances in experimental medicine and biology. - Cham : Springer International Publishing. - 0065-2598. ; 1111, s. 33-53
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Tidskriftsartikel (refereegranskat)
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| 8. |
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