| 1. |
- Feuerbacher, M., et al.
(författare)
-
The Samson phase, β-Mg2Al3, Revisited
- 2007
-
Ingår i: Zeitschrift für Kristallographie. - 0044-2968. ; 222:6, s. 259-288
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
- Abbafati, Cristiana, et al.
(författare)
-
- 2020
-
Tidskriftsartikel (refereegranskat)
|
|
| 3. |
|
|
| 4. |
- Galleberg, R. B., et al.
(författare)
-
Results after surgical treatment of liver metastases in patients with high-grade gastroenteropancreatic neuroendocrine carcinomas
- 2017
-
Ingår i: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983 .- 1532-2157. ; 43:9, s. 1682-1689
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are generally characterized by synchronous metastases, high aggressiveness and a dismal prognosis. Current international guidelines do not recommend surgical treatment of liver metastases, however the existing data are scarce. The aim of this study was to evaluate the results of curatively intended resection/radiofrequency ablation (RFA) of liver metastases in patients with metastatic GEP-NEC. Methods: 32 patients with a diagnosis of high-grade gastroenteropancreatic neuroendocrine neoplasm (Ki-67 > 20%) and with intended curative resection/RFA of liver metastases, were identified among 840 patients from two Nordic GEP-NEC registries. Tumor morphology (well vs poor differentiation) was reassessed. Overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan Meier analyses for the entire cohort and for subgroups. Results: Median OS after resection/RFA of liver metastases was 35.9 months (95% -CI: 20.6-51.3) with a five-year OS of 43%. The median PFS was 8.4 months (95% -CI: 3.9-13). Four patients (13%) were disease -free after 5 years. Two patients had well -differentiated morphology (NET G3) and 20 patients (63%) had Ki-67 >= 55%. A Ki-67 < 55% and receiving adjuvant chemotherapy were statistically significant factors of improved OS after liver resection/RFA. Conclusion: This study shows a long median and long term survival after liver surgery/RFA for these selected metastatic GEP-NEC patients, particularly for the group with a Ki-67 in the relatively lower G3 range. Our findings indicate a possible role for surgical treatment of liver metastases in the management of this patient population.
|
|
| 5. |
- Sorbye, H, et al.
(författare)
-
Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3) : the NORDIC NEC study
- 2013
-
Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 24:1, s. 152-160
-
Tidskriftsartikel (refereegranskat)abstract
- As studies on gastrointestinal neuroendocrine carcinoma (WHO G3) (GI-NEC) are limited, we reviewed clinical data to identify predictive and prognostic markers for advanced GI-NEC patients. Data from advanced GI-NEC patients diagnosed 2000-2009 were retrospectively registered at 12 Nordic hospitals. The median survival was 11 months in 252 patients given palliative chemotherapy and 1 month in 53 patients receiving best supportive care (BSC) only. The response rate to first-line chemotherapy was 31% and 33% had stable disease. Ki-67 < 55% was by receiver operating characteristic analysis the best cut-off value concerning correlation to the response rate. Patients with Ki-67 < 55% had a lower response rate (15% versus 42%, P < 0.001), but better survival than patients with Ki-67 >= 55% (14 versus10 months, P < 0.001). Platinum schedule did not affect the response rate or survival. The most important negative prognostic factors for survival were poor performance status (PS), primary colorectal tumors and elevated platelets or lactate dehydrogenase (LDH) levels. Advanced GI-NEC patients should be considered for chemotherapy treatment without delay.PS, colorectal primary and elevated platelets and LDH levels were prognostic factors for survival. Patients with Ki-67 < 55% were less responsive to platinum-based chemotherapy, but had a longer survival. Our data indicate that it may not be correct to consider all GI-NEC as one single disease entity.
|
|
| 6. |
|
|
| 7. |
- Andersson, Magnus, et al.
(författare)
-
Electronic and structural properties of Laves-phase MgZn(2) of varying chemical disorder
- 2010
-
Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 82:2, s. 024202-
-
Tidskriftsartikel (refereegranskat)abstract
- The C14 Laves-phase MgZn(2) has been investigated from 30 to 36 at. % Mg. In this way chemical disorder can be monitored over a limited concentration range and the influence on electron properties can be investigated. Our studies include thermodynamic calculations of atomic configurations of Mg and Zn at off-stoichiometric compositions, electronic-transport measurements, and electronic band-structure calculations of MgZn(2). The disorder introduced by alloying was found to be substitutional for all C14 alloys, and to have a markedly stronger effect on resistivity and magnetoresistance, Delta rho(B)/rho(0), on the Mg-rich side due to strain introduced when Mg substitutes for Zn. rho(T) and Hall constant were characteristic for weakly disordered binary alloys. Delta rho/rho of MgZn(2) was large, reached 6 at 4.2 K and 8 T, and decreased strongly at off-stoichiometric compositions. The results are discussed in view of the band-structure results and in terms of relations between atomic order and electronic properties. Several properties were found to resemble pure Zn. An empirical correlation over more than six orders of magnitude in Delta rho/rho was found for Zn and Zn-based alloys.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Karpus, V., et al.
(författare)
-
Coordination-induced structure of the Mg 2p core level in i-ZnMgR quasicrystals
- 2007
-
Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 76:15
-
Tidskriftsartikel (refereegranskat)abstract
- We present a detailed analysis of Mg 2p photoemission (PE) spectra in icosahedral ZnMgR (R=Y, Ho, Er) quasicrystals and in the crystalline Zn2Mg Laves phase. Synchrotron-radiation PE measurements were performed on in situ cleaved single-grain samples at 10(-10) mbar pressure and low, 90-150 K, temperature. The analysis of Mg 2p PE spectra in Zn2Mg reveals a surface shift of the core level of -0.12 eV. The Mg 2p PE spectra in i-ZnMgR quasicrystals are essentially broadened as compared to spectra in Zn2Mg Laves phase. The effect is due to the coordination-induced structure of the Mg 2p levels. Different local surroundings of Mg atoms in quasicrystals induce both different shifts of the Mg 2p level and splittings of its spin-orbit components. The local coordination potential at different Mg sites in the quasicrystalline lattice is calculated on the basis of the face-centered icosahedral ZnMgY atomic structure data, recently determined from the pair distribution function analysis. The coordination shifts calculated are spread within an interval of about 0.3 eV, while the splittings of the 2p(3/2) component are of the order of 1-10 meV. The simulated theoretical Mg 2p PE spectra of fci-ZnMgR quasicrystals perfectly fit the experimental data.
|
|
