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Sökning: WFRF:(Ayora S)

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  • Corvaisier, Matthieu, et al. (författare)
  • The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
  • 2021
  • Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 767-
  • Tidskriftsartikel (refereegranskat)abstract
    • Changes in the location of γ-tubulin ensure cell survival and preserve genome integrity. We investigated whether the nuclear accumulation of γ-tubulin facilitates the transport of proliferating cell nuclear antigen (PCNA) between the cytosolic and the nuclear compartment in mammalian cells. We found that the γ-tubulin meshwork assists in the recruitment of PCNA to chromatin. Also, decreased levels of γ-tubulin reduce the nuclear pool of PCNA. In addition, the γ-tubulin C terminus encodes a PCNA-interacting peptide (PIP) motif, and a γ-tubulin–PIP-mutant affects the nuclear accumulation of PCNA. In a cell-free system, PCNA and γ-tubulin formed a complex. In tumors, there is a significant positive correlation between TUBG1 and PCNA expression. Thus, we report a novel mechanism that constitutes the basis for tumor growth by which the γ-tubulin meshwork maintains indefinite proliferation by acting as an opportune scaffold for the transport of PCNA from the cytosol to the chromatin.
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  • Luis de la Vara, J., et al. (författare)
  • Assurance of Software-Intensive Medical Devices : What About Mental Harm?
  • 2023
  • Ingår i: 2023 53RD ANNUAL IEEE/IFIP INTERNATIONAL CONFERENCE ON DEPENDABLE SYSTEMS AND NETWORKS - SUPPLEMENTAL VOLUME, DSN-S. - : IEEE Computer Society. - 9798350325454 ; , s. 168-172
  • Konferensbidrag (refereegranskat)abstract
    • Interdisciplinary synergies are arising from the growing usage of software, e.g., between dependability assurance and mental health. In a context in which software-intensive medical devices are used for the treatment of mental illnesses such as schizophrenia, it is important to consider mental harm when dealing with and justifying system dependability. However, we are not aware of any publication on system assurance that has paid attention to mental harm in detail. This emerging idea should be considered for the success of the devices. We discuss why and how mental harm should be addressed for assurance of software-intensive medical devices, considering hazard and risk analysis, system compliance, dependability justification, and assurance evidence collection. We draw from prior more general work and from system examples for which mental health plays a major role.
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  • Resultat 1-3 av 3

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