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- Bäckman, Lisa, et al.
(författare)
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Effects of internet-based enhanced acceptance and commitment therapy integrating interoceptive exposure for panic disorder and the association between working alliance and outcome: A randomized controlled trial
- 2024
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Ingår i: Sweesrii 2024.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This study investigated the effectiveness of an improved internet-based Acceptance and Commitment Therapy (iACT) adapted for individuals with Panic Disorder (PD) and concurrent agoraphobia (AF), incorporating interoceptive exposure for better customization. The treatment, spanning eight modules over 10 weeks, demonstrated significant symptom reduction in the primary outcome Panic Disorder Severity Scale (PDSS-SR), with a large effect size (d=0.92) in a randomized controlled trial involving a wait-list control group (n=79). However, no significant impact was observed on the secondary outcome, Brunnsviken Brief Quality of Life Inventory (BBQ). Notably, 43% of of the assessed participants in the treatment group were diagnosed free from panic disorder. Utilizing weekly ratings of therapist-client working alliance (WAI-SR-T/C) and PDSS-SE, we explored their connection throughout the treatment and its association with the final outcome. We found a relation between therapist working alliance and the reduction of panic symptoms during treatment. However, there was no significant relationship observed for client-rated working alliance or with the final treatment outcome. This study suggests that this enhanced iACT can be an effective method for treating panic disorder and shows promise for use, particularly in cases where panic disorder is accompanied by agoraphobia. It is also shedding light on the role of alliance in internet-based treatments, however, here it is important to acknowledge that the sample size was small.
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| 3. |
- Josephsson, Staffan, et al.
(författare)
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Supporting everyday activities in Dementia : an intervention study
- 1993
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Ingår i: International Journal of Geriatric Psychiatry. - : John Wiley & Sons. - 0885-6230 .- 1099-1166. ; 8:5, s. 395-400
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Tidskriftsartikel (refereegranskat)abstract
- The efficacy of an intervention programme designed to support performance in activities of daily living was investigated in four patients with dementia at different levels of severity of impairment. Important features of the programme included that (a) task conditions should be highly supportive, (b) the importance of episodic and semantic memory skills for successful performance should be minimized, (c) an acceptable performance level should be possible to achieve using skills that are relatively well preserved in the disease, and (d) factors related to patients' motivation and habits should be taken into account. Performance gains were evaluated using the Assessment of Motor and Process Skills instrument. Results showed intervention-related gains in three patients. One of these patients maintained performance gains when environmental guidance (eg signs) was withdrawn, whereas the other two required environmental guidance in order to exhibit gains. The overall pattern of results suggests that this form of intervention related to everyday functioning in dementia is worthy of further empirical attention.
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| 4. |
- Lill, Christina M., et al.
(författare)
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Closing the case of APOE in multiple sclerosis : no association with disease risk in over 29 000 subjects
- 2012
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Ingår i: Journal of Medical Genetics. - : BMJ. - 0022-2593 .- 1468-6244. ; 49:9, s. 558-562
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Tidskriftsartikel (refereegranskat)abstract
- Background Single nucleotide polymorphisms (SNPs) rs429358 (ε4) and rs7412 (ε2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently.Methods We genotyped 12 740 subjects hitherto not studied for their APOE status, imputed raw genotype data from 8739 subjects from five independent genome-wide association studies datasets using the most recent high-resolution reference panels, and extracted genotype data for 8265 subjects from previous candidate gene assessments.Results Despite sufficient power to detect associations at genome-wide significance thresholds across a range of ORs, our analyses did not support a role of rs429358 or rs7412 on MS susceptibility. This included meta-analyses of the combined data across 13 913 MS cases and 15 831 controls (OR=0.95, p=0.259, and OR 1.07, p=0.0569, for rs429358 and rs7412, respectively).Conclusion Given the large sample size of our analyses, it is unlikely that the two APOE missense SNPs studied here exert any relevant effects on MS susceptibility.
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