| 1. |
- Cedergren Weber, Gustav, et al.
(författare)
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The Impact of COVID-19 on Parkinson's Disease : A Case-Controlled Registry and Questionnaire Study on Clinical Markers and Patients' Perceptions
- 2023
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Ingår i: Acta Neurologica Scandinavica. - : John Wiley & Sons. - 0001-6314 .- 1600-0404. ; 2023
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Parkinson's disease (PD) is a neurodegenerative disease with motor and nonmotor symptoms. Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Objectives: To explore how COVID-19 affects motor, nonmotor, and general health aspects of PD and to map how PD patients perceive their change in symptoms since falling ill with COVID-19.Method: The study was descriptive, case-controlled, and based on both registry and questionnaire data. At baseline, the controls were matched on age, sex, and disease severity. Information on the severity of the disease, nonmotor symptoms, motor symptoms, and general health was retrieved from the Swedish Registry for PD. Registry data from a COVID-19 group (n=45) and a control group (n=73), as well as questionnaires from a COVID-19 group (n=24) and a control group (n=42), were compared.Results: We did not find that SARS-CoV-2 infection affects any major aspect of nonmotor symptoms, motor symptoms, general health, and perception of change in PD patients' post-COVID-19. Compared to controls, the COVID-19 group reported a more positive subjective experience of pain and quality of life and a perception of change post-COVID-19 regarding general motor function, sleep quality, and mood (all p<0.05).Conclusion: Although SARS-CoV-2 infection does not seem to affect PD symptoms in any major respect, the subjective experience of several aspects of life in PD patients might be slightly improved post-COVID-19 compared to a control group. The findings warrant further investigations due to the small sample size and possible survivorship bias.
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| 2. |
- Lindblom, Per, 1974, et al.
(författare)
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Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
- 2003
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Ingår i: Genes & development. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 17:15, s. 1835-40
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Tidskriftsartikel (refereegranskat)abstract
- Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the pericellular space. To address the role of PDGF-B retention in vivo, we deleted the retention motif by gene targeting in mice. This resulted in defective investment of pericytes in the microvessel wall and delayed formation of the renal glomerulus mesangium. Long-term effects of lack of PDGF-B retention included severe retinal deterioration, glomerulosclerosis, and proteinuria. We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice.
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| 3. |
- Thottappillil, Rajeev, et al.
(författare)
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Response of Civilian Facilities to Intentional Electromagnetic Interference (IEMI), with Emphasis on the Swedish Railway Network
- 2005
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Konferensbidrag (refereegranskat)abstract
- Recently a research program was initiated in Sweden to investigate the possible susceptibility of IEMI to civilian networks, with emphasis on the Swedish railway network. The objective is to develop a methodology for investigating and protecting sensitive railway facilities against IEMI and to recommend ways in which EMI control in the railways could be improved for better defense against IEMI. Details of the research program and some preliminary results are presented in this paper.
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| 4. |
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| 5. |
- Allard, Erik, et al.
(författare)
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Comparing capillary electrophoresis : mass spectrometry fingerprints of urine samples obtained after intake of coffee, tea, or water.
- 2008
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 80:23, s. 8946-8955
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Tidskriftsartikel (refereegranskat)abstract
- Metabolomic fingerprinting is a growing strategy for characterizing complex biological samples without detailed prior knowledge about the metabolic system. A two-way analysis system with liquid separation and mass spectrometric detection provides detail-rich data suitable for such fingerprints. As a model study, human urine samples, obtained after intake of coffee, tea, or water, were analyzed with capillary electrophoresis electrospray ionization time-of-flight mass spectrometry (CE−ESI-TOF-MS). In-house-developed software (in Matlab) was utilized to manage and explore the large amount of data acquired (230 CE−MS runs, each with 50−100 million nonzero data points). After baseline and noise reduction, followed by suitable binning in time and m/z, the data sets comprised 9 and 14 million data points in negative and positive ESI mode, respectively. Finally, a signal threshold was applied, further reducing the number to about 100 000 data points per data set. A set of interactive exploratory tools, utilizing principal component analysis (PCA) and analysis of variance (ANOVA) results based on a general linear model, facilitated visual interpretation with score plots (for group assessment) and differential fingerprints (for “hot spot” detection). In the model study highly significant differences due to beverage intake were obtained among the 10 first principal components (p < 10−6 for two of the components in both ESI modes). Especially, the contrasts between “coffee” and “tea or water” indicated several “hot spots” with highly elevated intensities (e.g., for uncharged masses 93, 94, 109, 119, 123, 132, 148, 169, 178, 187, 190, and 193) suitable for further analysis, for example, with tandem MS.
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| 6. |
- Alm, Ove, et al.
(författare)
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A multiple coaxial wire for pressure calibration
- 1974
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Ingår i: Review of Scientific Instruments. - : American Institute of Physics (AIP). - 0034-6748 .- 1089-7623. ; 45:4, s. 594-595
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Tidskriftsartikel (refereegranskat)abstract
- A single wire containing several metals suitable for pressure calibration has been produced by extrusion. Coaxial combinations of Ce-Bi-TI and Ce-Bi-Ba have been prepared by the procedure described.
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| 7. |
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| 8. |
- Andersson, Per, et al.
(författare)
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Electrical resistance of Evanohm under pressure
- 1975
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Ingår i: Review of Scientific Instruments. - : American Institute of Physics (AIP). - 0034-6748 .- 1089-7623. ; 46:9, s. 1292-1293
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Tidskriftsartikel (refereegranskat)abstract
- The electrical resistance of Evanohm wire has been determined as a function of hydrostatic pressure. A Teflon cell with a novel type of electrical feedthrough was used to contain the fluid medium. The resistance was found to decrease approximately linearly by 0.3% up to 27 kilobar. The remarkably small variation of its resistance with temperature and pressure makes Evanohm a suitable material for strain measurements under pressure.
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| 9. |
- Andersson, Per, et al.
(författare)
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Pressure dependence of the thermal conductivity of an epoxy resin
- 1973
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Ingår i: Journal of Applied Physics. - : American Institute of Physics (AIP). - 0021-8979 .- 1089-7550. ; 44:2, s. 705-707
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Tidskriftsartikel (refereegranskat)abstract
- The pressure dependence of the thermal conductivity of Araldite has been determined in a cylindrical geometry at 300 K. The pressure coefficient was found to be independent of the percentage of hardener, the conductivity at 25 kbar being higher by the factor 1.75 ± 0.05 than at atmospheric pressure.
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| 10. |
- Andersson, Per, et al.
(författare)
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Pressure dependence of the thermal conductivity, thermal diffusivity, and specific heat of polyethylene
- 1973
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Ingår i: Journal of Applied Physics. - : American Institute of Physics (AIP). - 0021-8979 .- 1089-7550. ; 44:6, s. 2601-2605
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Tidskriftsartikel (refereegranskat)abstract
- The pressure dependence of the specific heat of high‐density polyethylene was determined from simultaneous measurements of thermal conductivity and diffusivity in a cylindrical geometry at 300 K and in the pressure range 0–25 kbar. The thermal conductivity and the diffusivity both increase strongly with pressure, the values at 25 kbar being higher by factors of 2.75 and 2.77, respectively, than those at atmospheric pressure. The specific heat decreases, most strongly so at low pressures, and its value at 25 kbar is 0.80 times that at atmospheric pressure. The thermal conductivity of low‐density polyethylene was determined as a function of pressure. Its value at 25 kbar was found to be 2.19 times that at atmospheric pressure. The difference in conductivity response to pressure between the two varieties is given a simple theoretical interpretation.
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