| 1. |
- Sun, Chengjun, et al.
(författare)
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CRYAB-650 C>G (rs2234702) affects susceptibility to type 1 diabetes and IAA-positivity in Swedish population
- 2012
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Ingår i: Human Immunology. - : Elsevier. - 0198-8859 .- 1879-1166. ; 73:7, s. 759-766
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. CRYAB gene, which encodes alpha B-crystallin (a member of small heat shock protein), was reported as a potential autoimmune target. In this study we investigated whether SNPs in the promoter region of CRYAB gene were also important in the etiology of Type 1 diabetes (T1D).METHODS: Genotyping of SNPs in the promoter region of CRYAB gene was performed in a Swedish cohort containing 444 T1D patients and 350 healthy controls. Three SNPs were included in this study: CRYAB-652 A>G (rs762550), -650 C>G (rs2234702) and -249 C > G (rs14133). Two SNPs (CRYAB-652 and -650) were not included in previous genome wide association studies.RESULTS: CRYAB-650 (rs2234702)*C allele was significantly more frequent in patients than in controls (OR = 1.48, Pc = 0.03). CRYAB-650*C allele was associated with IAA positivity (OR = 8.17, Pc < 0.0001) and IA-2A positivity (OR = 2.14, Pc = 0.005) in T1D patients. This association with IAA was amplified by high-risk HLA carrier state (OR = 10.6, P < 0.0001). No association was found between CRYAB-650 and other autoantibody positivity (GADA and ICA). CRYAB haplotypes were also associated with IAA and IA-2A positivity (highest OR = 2.07 and 2.11, respectively), these associations remain in high HLA-risk T1D patients.CONCLUSIONS: CRYAB-650 was associated with T1D in the Swedish cohort we studied. CRYAB-650*C allele might confers susceptibility to the development of T1D. CRYAB-650 was also associated with the development of IAA-positivity in T1D patients, especially in those carrying T1D high-risk HLA haplotypes.
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| 2. |
- Mundy, Lee G., et al.
(författare)
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High-resolution images of the Orion molecular ridge in the CS J = 2-1 transition
- 1988
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Ingår i: Astrophysical Journal. - Philadelphia, PA : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 325:1, s. 382-388
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Tidskriftsartikel (refereegranskat)abstract
- The authors have constructed 7arcsec.5 resolution images of the CS J = 2-1 emission from a 3arcmin.5 section of the Orion molecular ridge using a maximum entropy algorithm to combine Owens Valley Millimeter-Wave Interferometer and Onsala Space Observatory 20 m data. The resulting images include all of the flux and have positional accuracy of 1arcsec-2arcsec on the small-scale features. The observed section of the ridge includes four condensations. The condensations have dimensions from 0.03 to 0.11 pc and virial massses from 30 to 80 M_sun;. Approximately 70% of the total mass within the 3arcmin region is contained in these condensations.
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| 3. |
- Pettersson, Håkan, et al.
(författare)
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Optically induced charge storage and current generation in InAs quantum dots
- 2002
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - : American Physical Society. - 1098-0121 .- 1550-235X. ; 65:7, s. 0733041-0733044
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Tidskriftsartikel (refereegranskat)abstract
- We report on optically induced charge storage effects and current generation in self-assembled InAs quantum dots embedded in an InP matrix. Illumination with photons of energy higher than about 0.86 eV efficiently loads the dots with a maximum of about 1 hole/dot. The spectral response at lower photon energy is strongly enhanced at elevated temperatures. We present a detailed balance model for the dots and discuss the thermally assisted optical excitation processes pertinent to hole accumulation. We also show that these processes make the dots act as nanometer-scaled temperature-dependent current generators.
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| 4. |
- Alberdi, A., et al.
(författare)
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The high-frequency compact radio structure of the peculiar quasar 4C 39.25
- 1997
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Ingår i: Astronomy and Astrophysics. - : Springer-Verlag. - 0004-6361 .- 1432-0746. ; 327:2, s. 513-521
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Tidskriftsartikel (refereegranskat)abstract
- We present new high angular resolution images of the compact non-thermal radio source 4C 39.25 obtained from VLBI observations at λ1.3cm, λ7mm, and λ3mm wavelengths. These maps and Gaussian model-fits show that the milli-arcsecond to sub-milliarcsecond structure of 4C 39.25 consists of a complex bent core-jet structure with embedded moving and stationary VLBI components. Facilitated by the small observing beams and high angular resolutions obtained at mm-wavelengths, we measured the relative positions of the jet components with an accuracy of a few hundred micro-arcseconds. This allows the detailed followup of the ongoing merging process of a westward superluminally moving component (b_) with a stationary component a_, located at ~2.9 mas east of the putative core d_. In contrast to the other components of the structure with steeper spectra, the westernmost component d_ exhibits an inverted spectrum peaking between λ7mm and λ3mm, thus further supporting its identification as the VLBI core, self-absorbed at longer wavelengths. From two VLBI maps obtained nearly simultaneously at λ7mm and λ1.3cm, we made the first spectral index map of 4C 39.25 in this wavelength regime. The main characteristics of the spectral index distribution of the jet are pronounced changes of the spectral index between orientations parallel and transverse to the jet axis. Near the merging components a_ and b_ the spectral index steepens with increasing separation from d_. However, in the bridge of emission c_, which connects d_ with a_ and b_, the spectral index gradient has a direction transverse to the jet axis, suggesting a frequency dependent jet curvature and edge-brightening. A brief discussion of this behaviour within current jet models is presented.
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| 5. |
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| 6. |
- Bååth, Lars B.
(författare)
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Analys av avgaser med mikrovågspektroskopi
- 2004
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Rapport (refereegranskat)abstract
- Inom projektet har hittills genomförts följande aktiviteter:Inhämtat teoretiska kunskaper inom området mikrovågsteknikGenomfört studier avseende vilka molekyler som är av intresse för stål- och metallindustrin att mäta på.Kontrollerat mot JPL databas samt NBS om dessa molekyler finns definierade i mikrovågsområdet av det elektromagnetiska spektret och då på vilka frekvenser.Designat och tillverkat en sensor, bestående av antenner, mixer samt LO, som klarar av att mäta vid de relevanta molekylära frekvenserna.Testat och utvärderat sensortekniken på laboratorienivå avseende signalkarak- täristik.Genomfört pilotförsök på MEFOS: i. Höga gastemperaturer; ii. Olika gaskoncentrationerGenomförtverksförsök: i. LKAB, Rotary Kiln; ii. Boliden Mineral, KopparkonverterUtvärderat försöksdata
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| 7. |
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| 8. |
- Bååth, Lars B., et al.
(författare)
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Imaging with Interferometers
- 1998
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Ingår i: Proceedings SSAB Symposium on Image Analysis. ; , s. 4-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A scanning device based on changes in the reflections of an electromagnetic wave for use on wood the image can be calculated.
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| 9. |
- Bååth, Lars B., 1948-
(författare)
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Method and device for contactless level and interface detection
- 2006
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Patent (populärvet., debatt m.m.)abstract
- Method and apparatus for determining the thickness of material layers of a container-held substance comprising a first material disposed in an upper layer and a second material disposed in a lower layer, by transmitting a radio signal through the substance towards a container portion; receiving reflected signals from a surface of the upper layer, a surface of the second layer, and the container portion; varying the frequency of the transmitted signal to determine phase displacement between transmitted and reflected signals; determining optical distances to the surfaces and the container portion, dependent on the phase displacements; determining the thickness of one of said layers dependent on phase displacement through and index of refraction of that layer; and determining the thickness of the other layer dependent on the thickness of said one of said layers.
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| 10. |
- Bååth, Lars B., 1948-
(författare)
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Method for analysing a substance in a container
- 2006
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Patent (populärvet., debatt m.m.)abstract
- Method and apparatus for analyzing a substance in a container, the method comprising the steps of: disposing antenna means (3) at a predetermined geometrical distance (L) from a container portion (13); transmitting a signal from said antenna means through a surface portion (12) of the substance towards said container portion; receiving a first reflected signal in said antenna means from said container portion; determining a geometrical distance (L1) from the surface portion to the container portion; varying the frequency of the transmitted signal to determine a first phase displacement between the transmitted signal and the first reflected signal; determining an optical distance from the surface portion to the container portion based on the first phase displacement; and determining the index of refraction (nt) of said substance based on the optical and geometrical from the surface portion to the container portion.
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