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- Burvall, Anna, et al.
(författare)
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Simple lens axicon
- 2004
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Ingår i: Applied Optics. - 1559-128X .- 2155-3165. ; 43:25, s. 4838-4844
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Tidskriftsartikel (refereegranskat)abstract
- We present the design of a cemented doublet-lens axicon made from spherical surfaces only. Compared with diffractive axicons, refractive cone axicons, and earlier lens axicons with aspheric surfaces, this element is inexpensive and easy to manufacture even with large apertures. The lens axicon is based on the deliberate use of the spherical aberration of the surfaces. The design principles of the element and its characterization, numerically and experimentally, are presented in detail. Although performance was traded for simplicity and robustness, the results show that the lens axicon has the main axicon properties: a narrow, extended line focus of relatively constant width.
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- Larsson, Daniel H., et al.
(författare)
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First application of liquid-metal-jet sources for small-animal imaging : High-resolution CT and phase-contrast tumor demarcation
- 2013
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Ingår i: Medical physics (Lancaster). - : Wiley. - 0094-2405 .- 2473-4209. ; 40:2, s. 021909-
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Small-animal studies require images with high spatial resolution and high contrast due to the small scale of the structures. X-ray imaging systems for small animals are often limited by the microfocus source. Here, the authors investigate the applicability of liquid-metal-jet x-ray sources for such high-resolution small-animal imaging, both in tomography based on absorption and in soft-tissue tumor imaging based on in-line phase contrast. Methods: The experimental arrangement consists of a liquid-metal-jet x-ray source, the small-animal object on a rotating stage, and an imaging detector. The source-to-object and object-to-detector distances are adjusted for the preferred contrast mechanism. Two different liquid-metal-jet sources are used, one circulating a Ga/In/Sn alloy and the other an In/Ga alloy for higher penetration through thick tissue. Both sources are operated at 40-50 W electron-beam power with similar to 7 mu m x-ray spots, providing high spatial resolution in absorption imaging and high spatial coherence for the phase-contrast imaging. Results: High-resolution absorption imaging is demonstrated on mice with CT, showing 50 mu m bone details in the reconstructed slices. High-resolution phase-contrast soft-tissue imaging shows clear demarcation of mm-sized tumors at much lower dose than is required in absorption. Conclusions: This is the first application of liquid-metal-jet x-ray sources for whole-body small-animal x-ray imaging. In absorption, the method allows high-resolution tomographic skeletal imaging with potential for significantly shorter exposure times due to the power scalability of liquid-metal-jet sources. In phase contrast, the authors use a simple in-line arrangement to show distinct tumor demarcation of few-mm-sized tumors. This is, to their knowledge, the first small-animal tumor visualization with a laboratory phase-contrast system.
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