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- Taneja, P, et al.
(författare)
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Modulation of experimental facial pain via somatosensory stimuli targeting sensations of different valence
- 2020
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Ingår i: Journal of Oral Rehabilitation. - : John Wiley & Sons. - 1365-2842 .- 0305-182X. ; 47:6, s. 720-730
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Knowledge of pain modulation from orofacial somatosensory stimuli with different valence (pleasant-unpleasant) is limited.OBJECTIVES: To investigate: (1) The modulatory effects of painful, pleasant and unpleasant somatosensory stimuli on 2 models of experimental facial pain, (2) If modulation could be changed by blocking peripheral nerves via application of a local anesthetic: EMLA, or blocking endogenous opioid receptors via naltrexone, (3) If pain ratings were significantly correlated with participant psychological profiles.METHODS: 38 healthy women received experimental facial skin burning pain or jaw myalgia for four randomised sessions on different days. The painful region was stimulated with mechanical or thermal painful, pleasant, unpleasant and control stimuli, with ratings recorded before and during stimulation. Sessions differed in pre-treatment: EMLA/naltrexone/placebo tablet/cream.RESULTS: Significant effects of thermal or mechanical stimuli (P<0.017), but not session (P>0.102), were found on pain ratings for both models. In myalgia, painful cold resulted in a greater reduction in pain ratings than unpleasant cold, pleasant cold, control and pleasant warmth (P<0.004). Decreases in pain ratings from painful, unpleasant and pleasant mechanical stimuli was greater than control (P<0.002). In burning pain, painful cold resulted in a greater reduction in pain ratings than all but one of the other thermal stimuli (P<0.033). The pleasant mechanical stimulus reduced pain ratings more than all other mechanical stimuli (P≤0.003). There were no significant correlations between pain and psychometrics.CONCLUSION: Valence targeted thermal and mechanical stimuli modulated experimental myalgia and skin burning pain (P<0.017). Partially blocking peripheral afferents or opioid receptors did not affect modulation.
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- Wu, CZ, et al.
(författare)
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The Potential of Nano-Porous Surface Structure for Pain Therapeutic Applications: Surface Properties and Evaluation of Pain Perception
- 2020
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Ingår i: APPLIED SCIENCES-BASEL. - : MDPI AG. - 2076-3417. ; 10:13
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The objective of this study was to evaluate the biomaterial properties of nano-modified surface acupuncture needles and the effect of such needles on human pain perception by using pressure pain threshold (PPT) measurements. It is known that changing a material’s surface nano-topography or nanostructure has strong effects on its physical, chemical, and biological surface properties. However, there is no information in the literature about the stimulation characteristics of acupuncture needles with nano-topography or nanostructured surfaces. Based on the knowledge on nanostructured surfaces, it may be possible to potentiate the effects of acupuncture needle stimulation. The pressure pain sensitivity of the masseter muscle in the orofacial region was studied in 21 healthy volunteers in two randomized, double-blinded sessions: an active session of manual acupuncture manipulation with nano-modified surface needles, and an inactive session of sham acupuncture stimulation to control for possible placebo effects. Three acupuncture points were selected from classical Chinese medicine literature: LI4 (Hegu) on the hand, ST6 (Jiache) on the lower masseter region, and ST7 (Xiaguan) on the upper masseter region. PPT measurements, perceived sensations, and pain from the acupuncture were recorded. The results showed discrete yet significant differences in PPT values between the active and inactive acupuncture treatments and significantly higher pain scores from active acupuncture stimulation than from sham acupuncture. These results indicate subtle but significant effects of acupuncture stimulation with nano-modified surface needles, compared to sham acupuncture in healthy participants.
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