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- Mazaheri, Monir, 1977-, et al.
(författare)
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The effect of weight monitoring and recording on control of obesity and overweight
- 2011
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Ingår i: Eating and Weight Disorders. - 1124-4909 .- 1590-1262. ; 16:2, s. 137-141
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Obesity is one of the dilemmas of the recent century and imposes huge costs related to its complications and diseases on people and societies. This study aims to investigate whether recording and monitoring weight and its changes can modify eating habits and therefore weight control.METHODS: This is a quasi-experimental interventional study. Seventy nine of the staff of the University of Social Welfare and Rehabilitation (USWR) were randomly placed in two intervention (N=40) and control (39) groups. A standard weight scale and height meter was used to measure weight, height and body mass index (BMI). For the intervention group, weight was measured, recorded and announced to the participants twice a week for 3 months. For the control group, weight measurement and recording was done once in the beginning of the study and once at the end of the study. Data were analyzed using SPSS ver.11.5 and compared between groups.RESULTS: There were no significant differences in the average age between the groups. Mean pre-intervention weight was 87.08±10.9 Kg and 85.83±16.44 Kg in the intervention and control groups, respectively and was not significantly different. Mean post-intervention weight was 83.5 Kg in the intervention group, which was significantly different from pre-intervention weight. Mean post-intervention weight was 86.31 Kg in the control group that was not significantly different from pre-intervention weight.CONCLUSION: Recording and monitoring weight and its changes in overweight people can affect weight control since knowledge and insight about weight may motivate people to modify their eating habits. We therefore recommend this strategy as an adjuvant to weight control programs.
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- Delbari, MT, et al.
(författare)
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Clinical Manifestations, Immunological Characteristics and Genetic Analysis of Patients with Hyper-Immunoglobulin M Syndrome in Iran
- 2019
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Ingår i: International archives of allergy and immunology. - : S. Karger AG. - 1423-0097 .- 1018-2438. ; 180:1, s. 52-63
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Hyper-immunoglobulin M (HIGM) syndrome is a rare heterogeneous group of primary immunodeficiency disorders characterized by low or absent serum levels of IgG and IgA along with normal or elevated serum levels of IgM. <b><i>Methods:</i></b> Clinical and immunological data were collected from the 75 patients’ medical records diagnosed in Children’s Medical Center affiliated to Tehran University Medical Sciences and other Universities of Medical Sciences in Iran. Among 75 selected patients, 48 patients (64%) were analyzed genetically using targeted and whole-exome sequencing. <b><i>Results:</i></b> The ratio of male to female was 2.9:1. The median age at the onset of the disease, time of diagnosis, and diagnostic delay were 10.5, 50, and 24 months, respectively. Pneumonia and lower respiratory tract infections (61.3%) were the most common complications. Responsible genes were identified in 35 patients (72.9%) out 48 ge<i>netically</i> analyzed patients. <i>Cluster of differentiation 40 ligand</i> gene was the most mutated gene observed in 24 patients (68.5%) followed by <i>activation-induced cytidine deaminase</i> gene in 7 patients, <i>lipopolysaccharide-responsive and beige-like anchor</i> (1 patient), <i>nuclear factor-kappa-B essential modulator</i> (1 patient), <i>phosphoinositide-3-kinase regulatory subunit 1</i> (1 patient), and <i>nuclear factor kappa B subunit 1</i> (1 patient) genes. Nineteen (25.3%) patients died during the study period, and pneumonia was the major cause of death occurred in 6 (31.6%) patients. <b><i>Conclusion:</i></b> Physicians in our country should carefully pay attention to respiratory tract infections and pneumonia, particularly in patients with a positive family history. Further investigations are required for detection of new genes and pathways resulting in HIGM phenotype.
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- Kumar, Manish, 1982, et al.
(författare)
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Gut microbiota dysbiosis is associated with malnutrition and reduced plasma amino acid levels: Lessons from genome-scale metabolic modeling
- 2018
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Ingår i: Metabolic Engineering. - : Elsevier BV. - 1096-7176 .- 1096-7184. ; 49, s. 128-142
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Tidskriftsartikel (refereegranskat)abstract
- Malnutrition is a severe non-communicable disease, which is prevalent in children from low-income countries. Recently, a number of metagenomics studies have illustrated associations between the altered gut microbiota and child malnutrition. However, these studies did not examine metabolic functions and interactions between individual species in the gut microbiota during health and malnutrition. Here, we applied genome-scale metabolic modeling to model the gut microbial species, which were selected from healthy and malnourished children from three countries. Our analysis showed reduced metabolite production capabilities in children from two lowincome countries compared with a high-income country. Additionally, the models were also used to predict the community-level metabolic potentials of gut microbes and the patterns of pairwise interactions among species. Hereby we found that due to bacterial interactions there may be reduced production of certain amino acids in malnourished children compared with healthy children from the same communities. To gain insight into alterations in the metabolism of malnourished (stunted) children, we also performed targeted plasma metabolic profiling in the first 2 years of life of 25 healthy and 25 stunted children. Plasma metabolic profiling further revealed that stunted children had reduced plasma levels of essential amino acids compared to healthy controls. Our analyses provide a framework for future efforts towards further characterization of gut microbial metabolic capabilities and their contribution to malnutrition.
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