| 1. |
- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 2. |
- Aaron, F. D., et al.
(författare)
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Measurement of diffractive scattering of photons with large momentum transfer at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 672:3, s. 219-226
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Tidskriftsartikel (refereegranskat)abstract
- The first measurement of diffractive scattering of quasi-real photons with large momentum transfer gamma p -> gamma Y, where Y is the proton dissociative system, is made using the H1 detector at HERA. The measurement is performed for initial photon virtualities Q(2) < 0.01 GeV2. Single differential cross sections are Measured as a function of W, the incident photon-proton centre of mass energy, and t, the square of the four-momentum transferred at the proton vertex, in the range 175 < W < 247 GeV and 4 < |t| < 36 GeV2. The W dependence is well described by a model based on perturbative QCD using a leading logarithmic approximation of the BFKL evolution. The measured |t| dependence is harder than that predicted by the model and those observed in exclusive vector meson production. (C) 2009 Published by Elsevier B.V.
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| 3. |
- Aaron, F. D., et al.
(författare)
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Strangeness production at low Q(2) in deep-inelastic ep scattering at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 61:2, s. 185-205
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Tidskriftsartikel (refereegranskat)abstract
- The production of neutral strange hadrons is investigated using deep-inelastic scattering events measured with the H1 detector at HERA. The measurements are made in the phase space defined by the negative four-momentum transfer squared of the photon 2 < Q(2) < 100 GeV2 and the inelasticity 0.1 < y < 0.6. The K-s(0) s and Lambda((Lambda) over bar) production cross sections and their ratios are determined. K-s(0) s production is compared to the production of charged particles in the same region of phase space. The Lambda-(Lambda) over bar asymmetry is also measured and found to be consistent with zero. Predictions of leading order Monte Carlo programs are compared to the data.
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| 4. |
- Aaron, F. D., et al.
(författare)
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Measurement of the proton structure function F-L(x, Q(2)) at low x
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 665:4, s. 139-146
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Tidskriftsartikel (refereegranskat)abstract
- A first measurement is reported of the longitudinal proton structure function FL(X, Q(2)) at the ep collider HERA. It is based on inclusive deep inelastic e(+)p scattering cross section measurements with a positron beam energy of 27.5 GeV and proton beam energies of 920, 575 and 460 GeV. Employing the energy dependence of the cross section, FL is measured in a range of squared four-momentum transfers 12 <= Q2 <=, 90 GeV2 and low Bjorken x 0.00024 <= x <= 0.0036. The F-L values agree with higher order QCD calculations based on parton densities obtained using cross section data previously measured at HERA. (C) 2008 Elsevier B.V. All rights reserved.
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| 5. |
- Aaron, F. D., et al.
(författare)
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Multi-lepton production at high transverse momenta in ep collisions at HERA
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 668:4, s. 268-276
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Tidskriftsartikel (refereegranskat)abstract
- Processes leading to a final state with at least two high transverse momentum leptons (electrons or muons) are studied using the full e(+/-) p data sample collected by the H1 experiment at HERA. The data correspond to an integrated luminosity of 463 pb(-1). Di-lepton and tri-lepton event classes are investigated. Cross sections of the production of e(+)e(-) and mu(+)mu(-) pairs are derived in a restricted phase space dominated by photon-photon collisions. In general, good agreement is found with Standard Model predictions. Events are observed with a total scalar sum of lepton transverse momenta above 100 GeV where the Standard Model expectation is low. In this region, combining di-lepton and tri-lepton classes, five events are observed in e(+) p collisions, compared to a Standard Model expectation of 0.96 +/- 0.12, while no such event is observed in e(-) p data for 0.64 +/- 0.09 expected. (C) 2008 Elsevier B.V. All rights reserved.
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| 6. |
- Aaron, F. D., et al.
(författare)
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Search for excited electrons in ep collisions at HERA
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 666:2, s. 131-139
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Tidskriftsartikel (refereegranskat)abstract
- A search for excited electrons is performed using the full e(+/-) p data sample collected by the HI experiment at HERA, corresponding to a total luminosity of 475 pb(-1). The electroweak decays of excited electrons e* -> e gamma, e* -> eZ and e* -> vW with subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for excited electron production is found. Mass dependent exclusion limits on e* production cross sections and on the ratio f/Lambda of the coupling to the compositeness scale are derived within gauge mediated models. These limits extend the excluded region compared to previous excited electron searches. The e* production via contact interactions is also addressed for the first time in ep collisions. (C) 2008 Elsevier B.V. All rights reserved.
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| 7. |
- Aaron, F. D., et al.
(författare)
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Study of charm fragmentation into D (* +/-) mesons in deep-inelastic scattering at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 59:3, s. 589-606
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Tidskriftsartikel (refereegranskat)abstract
- The process of charm quark fragmentation is studied using D (* +/-) meson production in deep-inelastic scattering as measured by the H1 detector at HERA. The parameters of fragmentation functions are extracted for QCD models based on leading order matrix elements and DGLAP or CCFM evolution of partons together with string fragmentation and particle decays. Additionally, they are determined for a next-to-leading order QCD calculation in the fixed flavour number scheme using the independent fragmentation of charm quarks to D (* +/-) mesons. Two different regions of phase space are investigated defined by the presence or absence of a jet containing the D (* +/-) meson in the event. The fragmentation parameters extracted for the two phase space regions are found to be different.
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| 8. |
- Angeles-Martinez, R., et al.
(författare)
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Transverse Momentum Dependent (TMD) Parton Distribution Functions: Status and Prospects
- 2015
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Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 46:12, s. 2501-2534
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Tidskriftsartikel (refereegranskat)abstract
- We review transverse momentum dependent (TMD) parton distribution functions, their application to topical issues in high-energy physics phenomenology, and their theoretical connections with QCD resummation, evolution and factorization theorems. We illustrate the use of TMDs via examples of multi-scale problems in hadronic collisions. These include transverse momentum q(T) spectra of Higgs and vector bosons for low q(T), and azimuthal correlations in the production of multiple jets associated with heavy bosons at large jet masses. We discuss computational tools for TMDs, and present the application of a new tool, TMDLIB, to parton density fits and parameterizations.
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| 9. |
- Fuchs, A., et al.
(författare)
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Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
- 2018
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Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.
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| 10. |
- Vazquez, Sara E., et al.
(författare)
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Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq
- 2022
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood forms of immune dysregulation. Despite several successful implementations of PhIP-seq for autoantigen discovery, including our previous work (Vazquez et al., 2020), current protocols are inherently difficult to scale to accommodate large cohorts of cases and importantly, healthy controls. Here, we develop and validate a high throughput extension of PhIP-seq in various etiologies of autoimmune and inflammatory diseases, including APS1, IPEX, RAG1/2 deficiency, Kawasaki disease (KD), multisystem inflammatory syndrome in children (MIS-C), and finally, mild and severe forms of COVID-19. We demonstrate that these scaled datasets enable machine-learning approaches that result in robust prediction of disease status, as well as the ability to detect both known and novel autoantigens, such as prodynorphin (PDYN) in APS1 patients, and intestinally expressed proteins BEST4 and BTNL8 in IPEX patients. Remarkably, BEST4 antibodies were also found in two patients with RAG1/2 deficiency, one of whom had very early onset IBD. Scaled PhIP-seq examination of both MIS-C and KD demonstrated rare, overlapping antigens, including CGNL1, as well as several strongly enriched putative pneumonia-associated antigens in severe COVID-19, including the endosomal protein EEA1. Together, scaled PhIP-seq provides a valuable tool for broadly assessing both rare and common autoantigen overlap between autoimmune diseases of varying origins and etiologies.
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