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- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 4. |
- Drake, TM, et al.
(författare)
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Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
- 2020
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Ingår i: BMJ global health. - : BMJ. - 2059-7908. ; 5:12
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Tidskriftsartikel (refereegranskat)abstract
- Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.MethodsA multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).ResultsOf 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.ConclusionThe odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
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| 5. |
- Ghaly, Montaser, et al.
(författare)
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ZnO/spiral-shaped glass for solar photocatalytic oxidation of Reactive Red 120
- 2014
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Ingår i: Arabian Journal of Chemistry. - : Elsevier BV. - 1878-5352 .- 1878-5379.
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Tidskriftsartikel (refereegranskat)abstract
- ZnO/glass spiral (GS) was prepared by immobilization of ZnO on GS with facilemethod, and was characterized by X-ray diffraction analysis (XRD), scanning electron microscope(SEM) and the crystallite size of ZnO on GS surface was calculated. SEM showed rod-like shape ofZnO particles on GS surface. Photocatalytic activity of prepared immobilized photocatalyst wasinvestigated for decolourization and degradation of C.I. Reactive Red 120 (RR-120) dye under sunlight.The kinetics of decolourization and degradation removal has been investigated. The effect ofpH on decolourization and degradation of dye was studied. The decolourization and degradation ofdye were followed by pseudo-first order reaction. The decolourization and degradation of RR-120dye were enhanced by H2O2 addition to definite dosage beyond that the effect is diminished. Also,the reusability of immobilized ZnO on GS was tested for photocatalytic degradation of dye and itwas worth noting that it has high efficiency with slight decrease (5%) after five successive runs.
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| 6. |
- Khattab, Ibrahim A., et al.
(författare)
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Photocatalytic degradation of azo dye Reactive Red 15 over synthesized titanium and zinc oxides photocatalysts : a comparative study
- 2012
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Ingår i: Desalination and Water Treatment. - : Informa UK Limited. - 1944-3994 .- 1944-3986. ; 48:1-3, s. 120-129
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Tidskriftsartikel (refereegranskat)abstract
- Nanoparticle TiO2 and ZnO were prepared by facile method. The XRD pattern study shows that there is no obvious difference in crystal composition of various shapes of TiO2 and ZnO. The photocatalytic degradation of Reactive Red 15, commonly used as a textile dye, using synthesized titanium and zinc oxides was investigated. The effects of influential parameters such as initial pH, catalyst loading, initial dye concentration and addition of hydrogen peroxide were studied. The degradation efficiency was expressed by the removal of color and chemical oxygen demand (COD). The study reveals that: (1) Both catalysts, under corresponding optimal conditions, can be employed as an effective photocatalyst for the elimination of color and COD from dye wastewater. Also, ZnO is more efficient catalyst than TiO2; (2) Addition of proper amount of hydrogen peroxide improves both the decolorization and the degradation of the dye; (3) The photocatalytic degradation of Reactive Red 15, in the presence of both photocatalysts, obeyed pseudo-first order kinetics. The biodegradability ratio BOD5/COD increases from original zero up to 0.52 and 0.6 within 90 minutes irradiation time using 1 and 0.75 g/L TiO2 and ZnO, respectively.
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| 7. |
- Badawy, Shaimaa Ali, et al.
(författare)
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Multivariate similarity-based conformity measure (MSCM : An outlier detection measure for data mining applications
- 2008
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Ingår i: Proceedings of the IASTED International Conference on Artificial Intelligence and Applications Machine Learning. - Anaheim, Calif : ACTA Press. - 9780889867093 ; , s. 314-320
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Konferensbidrag (refereegranskat)abstract
- Outliers, the odd objects in the dataset, can be viewed from two different perspectives; the outliers as undesirable objects that should be treated or deleted in the data preparation step of the data mining process, and the outliers as interesting objects that are identified for their own interest in the data mining step of the mining process. In the latter case, outliers shouldn't be removed, that's why one of the main categories of tasks performed by data mining techniques is outlier detection. Applications that make use of such detection include credit card fraud detection and network intrusion detection. Most of the available outlier detection techniques rely in a distance measure to compare the objects in the dataset which imposed the restriction of dealing with numeric data. In this paper a new multivariate similarity-based conformity measure (MSCM) is suggested to be used to detect outliers in datasets that contain attributes of different data types. The MSCM satisfies two other desirable features; being a multivariate measure and giving ranking instead of a binary judgment of the object. The measure has been applied on three different datasets in order to be evaluated; the measure has shown good results in these experiments.
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| 8. |
- Dhakal, Binod, et al.
(författare)
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Hematopoietic cell transplantation utilization and outcomes for primary plasma cell leukemia in the current era
- 2020
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Ingår i: Leukemia. - : SPRINGERNATURE. - 0887-6924 .- 1476-5551. ; 34:12, s. 3338-3347
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Tidskriftsartikel (refereegranskat)abstract
- The outcomes of patients with primary plasma cell leukemia (pPCL) after undergoing hematopoietic cell transplantation (HCT) in the novel agent era are unknown. We report outcomes of 348 patients with pPCL receiving autologous (auto-) HCT (n = 277) and allogeneic (allo-) HCT (n = 71) between 2008 and 2015. Median age was 60 years and 56 years for auto- and allo-HCT respectively. For auto-HCT, the 4-year outcomes were: non-relapse mortality (NRM) 7% (4-11%), relapse (REL) 76% (69-82%), progression-free survival (PFS) 17% (13-23%), and overall survival (OS) 28% (22-35%). Karnofsky performance status (KPS) > 90 and >= very good partial response (VGPR) predicted superior OS in multi-variate analysis for auto-HCT. For allo-HCT, the 4-year outcomes were: NRM 12% (5-21%), REL 69% (56-81%), PFS 19% (10-31%), and OS 31% (19-44%). Compared with prior CIBMTR pPCL patients (1995-2006), inferior survival was noted in the current cohort (3-year OS, 39% vs. 38% in allo-HCT, and 62% vs. 35% in auto-HCT) respectively. However, we noted an increased HCT utilization, from 12% (7-21%) in 1995 to 46% (34-64%) in 2009 using SEER data (available till 2009). Despite modern induction translating to higher proportion receiving HCT, the outcomes remain poor in pPCL patients, mainly derived by high relapse rates post-HCT.
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| 9. |
- Jagadeesh, Deepa, et al.
(författare)
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Outcomes of rituximab‐BEAM versus BEAM conditioning regimen in patients with diffuse large B cell lymphoma undergoing autologous transplantation
- 2020
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Ingår i: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 126:10, s. 2279-2287
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Although rituximab-based high-dose therapy is frequently used in diffuse large B cell lymphoma (DLBCL) patients undergoing autologous hematopoietic cell transplantation (auto-HCT), data supporting the benefits are not available. Herein, we report the impact of rituximab-based conditioning on auto-HCT outcomes in patients who have DLBCL. METHODS Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, 862 adult DLBCL patients undergoing auto-HCT between 2003 and 2017 using BEAM (BCNU, etoposide, cytarabine, melphalan) conditioning regimen were included. All patients received frontline rituximab-containing chemoimmunotherapy and had chemosensitive disease pre-HCT. Early chemoimmunotherapy failure was defined as not achieving complete remission (CR) after frontline chemoimmunotherapy or relapse within 1 year of initial diagnosis. The primary outcome was overall survival (OS). RESULTS The study cohort was divided into 2 groups: BEAM (n = 667) and R-BEAM (n = 195). On multivariate analysis, no significant difference was seen in OS (P = .83) or progression-free survival (PFS) (P = .61) across the 2 cohorts. No significant association between the use of rituximab and risk of relapse (P = .15) or nonrelapse mortality (P = .12) was observed. Variables independently associated with lower OS included older age at auto-HCT (P < .001), absence of CR at auto-HCT (P < .001) and early chemoimmunotherapy failure (P < .001). Older age (P < .0002) and non-CR pre-HCT (P < .0001) were also associated with inferior PFS. There was no significant difference in early infectious complications between the 2 cohorts. CONCLUSION In this large registry analysis of DLBCL patients undergoing auto-HCT, the addition of rituximab to the BEAM conditioning regimen had no impact on transplantation outcomes. Older age, absence of CR pre auto-HCT, and early chemoimmunotherapy failure were associated with inferior survival.
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| 10. |
- Munshi, Pashna N., et al.
(författare)
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Age no bar : A CIBMTR analysis of elderly patients undergoing autologous hematopoietic cell transplantation for multiple myeloma
- 2020
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Ingår i: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 126:23, s. 5077-5087
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Tidskriftsartikel (refereegranskat)abstract
- Background Upfront autologous hematopoietic stem cell transplantation (AHCT) remains an important therapy in the management of patients with multiple myeloma (MM), a disease of older adults. Methods The authors investigated the outcomes of AHCT in patients with MM who were aged >= 70 years. The Center for International Blood and Marrow Transplant Research (CIBMTR) database registered 15,999 patients with MM in the United States within 12 months of diagnosis during 2013 through 2017; a total of 2092 patients were aged >= 70 years. Nonrecurrence mortality (NRM), disease recurrence and/or progression (relapse; REL), progression-free survival (PFS), and overall survival (OS) were modeled using Cox proportional hazards models with age at transplantation as the main effect. Because of the large sample size, aPvalue <.01 was considered to be statistically significant a priori. Results An increase in AHCT was noted in 2017 (28%) compared with 2013 (15%) among patients aged >= 70 years. Although approximately 82% of patients received melphalan (Mel) at a dose of 200 mg/m(2)overall, 58% of the patients aged >= 70 years received Mel at a dose of 140 mg/m(2). On multivariate analysis, patients aged >= 70 years demonstrated no difference with regard to NRM (hazard ratio [HR] 1.3; 99% confidence interval [99% CI], 1-1.7 [P = .06]), REL (HR, 1.03; 99% CI, 0.9-1.1 [P = 0.6]), PFS (HR, 1.06; 99% CI, 1-1.2 [P = 0.2]), and OS (HR, 1.2; 99% CI, 1-1.4 [P = .02]) compared with the reference group (those aged 60-69 years). In patients aged >= 70 years, Mel administered at a dose of 140 mg/m(2)was found to be associated with worse outcomes compared with Mel administered at a dose of 200 mg/m(2), including day 100 NRM (1% [95% CI, 1%-2%] vs 0% [95% CI, 0%-1%];P = .003]), 2-year PFS (64% [95% CI, 60%-67%] vs 69% [95% CI, 66%-73%];P = .003), and 2-year OS (85% [95% CI, 82%-87%] vs 89% [95% CI, 86%-91%];P = .01]), likely representing frailty. Conclusions The results of the current study demonstrated that AHCT remains an effective consolidation therapy among patients with MM across all age groups.
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