SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Badiola Juan J.) "

Sökning: WFRF:(Badiola Juan J.)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Albert, Marie Christine, et al. (författare)
  • Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality
  • 2024
  • Ingår i: Cell Death and Differentiation. - 1350-9047.
  • Tidskriftsartikel (refereegranskat)abstract
    • The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a novel mouse-adapted SARS-CoV-2 model (MA20) that recapitulates key pathological features of COVID-19. Concomitantly with occurrence of cell death and inflammation, FasL expression was significantly increased on inflammatory monocytic macrophages and NK cells in the lungs of MA20-infected mice. Importantly, therapeutic FasL inhibition markedly increased survival of both, young and old MA20-infected mice coincident with substantially reduced cell death and inflammation in their lungs. Intriguingly, FasL was also increased in the bronchoalveolar lavage fluid of critically-ill COVID-19 patients. Together, these results identify FasL as a crucial host factor driving the immuno-pathology that underlies COVID-19 severity and lethality, and imply that patients with severe COVID-19 may significantly benefit from therapeutic inhibition of FasL.
  •  
2.
  • Carracedo, Juan Carlos, et al. (författare)
  • Geological Hazards in the Teide Volcanic Complex
  • 2013
  • Ingår i: Teide Volcano. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783642258923 - 9783642258930 ; , s. 249-272
  • Bokkapitel (refereegranskat)abstract
    • The island of Tenerife displays contrasted densities of population, from the densely occupied coastal zones (including tourist resorts, airport, energy facilities, etc.) to the sparsely populated forests and mountainous highlands, where most of the recent volcanic events are located. Considering the low frequency of historical eruptions (compared to Hawaii or Reunion Island for example), the assessment of geological hazards must also rely on the analysis and interpretation of prehistorical events, going back to at least the Late Quaternary. In this chapter, we review the hazards related to Teide’s volcanism, but also those from increased seismicity and from slope instability. We discuss the origin of low magnitude earthquakes, and particularly the 2004 episode of unrest. New estimates on cumulative volumes for resurfacing by lava flows during the last few thousand years are provided to serve as a tool for building a lava flow hazard map of Tenerife. Hazards related to explosive activity are also considered and although possible, with phreatomagmatic eruptions being the most likely style anticipated, explosive events are of relatively low probability at Teide in the near future.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy