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Sökning: WFRF:(Bal Mert)

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1.
  • Abrishambaf, Reza, et al. (författare)
  • Distributed home automation system based on IEC61499 function blocks and wireless sensor networks
  • 2017
  • Ingår i: Proceedings of the IEEE International Conference on Industrial Technology. - Piscataway, NJ : Institute of Electrical and Electronics Engineers (IEEE). - 9781509053209 ; , s. 1354-1359
  • Konferensbidrag (refereegranskat)abstract
    • In this paper, a distributed home automation system will be demonstrated. Traditional systems are based on a central controller where all the decisions are made. The proposed control architecture is a solution to overcome the problems such as the lack of flexibility and re-configurability that most of the conventional systems have. This has been achieved by employing a method based on the new IEC 61499 function block standard, which is proposed for distributed control systems. This paper also proposes a wireless sensor network as the system infrastructure in addition to the function blocks in order to implement the Internet-of-Things technology into the area of home automation as a solution for distributed monitoring and control. The proposed system has been implemented in both Cyber (nxtControl) and Physical (Contiki-OS) level to show the applicability of the solution
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2.
  • Kalyoncu, Sibel, et al. (författare)
  • Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris
  • 2023
  • Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based vaccines are easier and cheaper to produce and do not require special storage/transportation conditions, they are suitable for low-/middle-income countries. Here, we report our vaccine development studies with the receptor binding domain of the SARS-CoV-2 Delta Plus strain (RBD-DP) which caused increased hospitalizations compared to other variants. First, we expressed RBD-DP in the Pichia pastoris yeast system and upscaled it to a 5-L fermenter for production. After three-step purification, we obtained RBD-DP with > 95% purity from a protein yield of > 1 g/L of supernatant. Several biophysical and biochemical characterizations were performed to confirm its identity, stability, and functionality. Then, it was formulated in different contents with Alum and CpG for mice immunization. After three doses of immunization, IgG titers from sera reached to > 106 and most importantly it showed high T-cell responses which are required for an effective vaccine to prevent severe COVID-19 disease. A live neutralization test was performed with both the Wuhan strain (B.1.1.7) and Delta strain (B.1.617.2) and it showed high neutralization antibody content for both strains. A challenge study with SARS-CoV-2 infected K18-hACE2 transgenic mice showed good immunoprotective activity with no viruses in the lungs and no lung inflammation for all immunized mice.
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