| 1. |
- Anchieta, Rodolfo B., et al.
(författare)
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Mechanical Property Assessment of Bone Healing around a Titanium-Zirconium Alloy Dental Implant
- 2014
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Ingår i: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1523-0899 .- 1708-8208. ; 16:6, s. 913-919
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundIt has been reported that titanium-zirconium alloy with 13-17% zirconium (TiZr1317) implants show higher biomechanical stability and bone area percentage relative to commercially pure titanium (cpTi) grade 4 fixtures. PurposeThis study aimed to determine whether the higher stability for TiZr1317 implants is associated with higher mechanical properties of remodeling bone in the areas around the implants. Materials and MethodsThis study utilized 36 implants (n=18: TiZr1317, n=18: cpTi), which were placed in the healed ridges of the mandibular premolar and first molar of 12 mini pigs (n=3 implants/animal). After 4 weeks in vivo, the samples were retrieved, and resin-embedded histologic sections of approximately 100m in thickness were prepared. In order to determine the nanomechanical properties, nanoindentation (n=30 tests/specimen) was performed on the bone tissue of the sections under wet conditions with maximum load of 300N (loading rate: 60N/s). ResultsThe mean (standard deviation) elastic modulus (E) and hardness (H) for the TiZr1317 group were 2.73 +/- 0.50GPa and 0.116 +/- 0.017GPa, respectively. For the cpTi group, values were 2.68 +/- 0.51GPa and 0.110 +/- 0.017GPa for E and H, respectively. Although slightly higher mechanical properties values were observed for the TiZr1317 implants relative to the cpTi for both elastic modulus and hardness, these differences were not significant (E=p>0.75; H=p>0.59). ConclusionsThe titanium-zirconium alloy used in this study presented similar degrees of nanomechanical properties to that of the cpTi implants.
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| 2. |
- Bougas, Kostas, et al.
(författare)
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In vivo evaluation of a novel implant coating agent : laminin-1.
- 2014
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Ingår i: Clinical Implant Dentistry and Related Research. - : Wiley Periodicals. - 1523-0899 .- 1708-8208. ; 16:5, s. 728-35
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The aim of this study was to assess the effect of implant coating with laminin-1 on the early stages of osseointegration in vivo.MATERIALS AND METHODS: Turned titanium implants were coated with the osteoprogenitor-stimulating protein, laminin-1 (TL). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants (T), alkali- and heat-treated implants (AH), and AH implants coated with laminin-1.RESULTS: After 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH. Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone.CONCLUSIONS: Within the limitations of this study, our results suggest a great potential for laminin-1 as a coating agent. A turned implant surface coated with laminin-1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.
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| 3. |
- Jimbo, Ryo, et al.
(författare)
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Histomorphometry and bone mechanical property evolution around different implant systems at early healing stages : an experimental study in dogs
- 2013
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Ingår i: Implant Dentistry. - : Lamy, Wolters Kluwer. - 1056-6163 .- 1538-2982. ; 22:6, s. 596-603
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Commercial implants differ at macro-, micro-, and nanolevels, which makes it difficult to distinguish their effect on osseointegration. The aim of this study was to evaluate the early integration of 5 commercially available implants (Astra OsseoSpeed, Straumann SLA, Intra-Lock Blossom Ossean, Nobel Active, and OsseoFix) by histomorphometry and nanoindentation. MATERIALS AND METHODS: Implants were installed in the tibiae of 18 beagle dogs. Samples were retrieved at 1, 3, and 6 weeks (n = 6 for each time point) and were histologically and nanomechanically evaluated. RESULTS: The results presented that both time (P < 0.01) and implant system and time interaction (P < 0.02) significantly affected the bone-to-implant contact (BIC). At 1 week, the different groups presented statistically different outcomes. No significant changes in BIC were noted thereafter. There were no significant differences in rank elastic modulus (E) or in rank hardness (H) for time (E: P > 0.80; H: P > 0.75) or implant system (E: P > 0.90; H: P > 0.85). CONCLUSIONS: The effect of different implant designs on osseointegration was evident especially at early stages of bone healing.
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| 4. |
- Tovar, Nick, et al.
(författare)
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Modification of Xenogeneic Graft Materials for Improved Release of P-15 Peptides in a Calvarium Defect Model
- 2014
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Ingår i: The Journal of craniofacial surgery (Print). - : Lippincott Williams & Wilkins. - 1049-2275 .- 1536-3732. ; 25:1, s. 70-76
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Tidskriftsartikel (refereegranskat)abstract
- Particulate bone augmentation is an established clinical alternative to regenerate bone. However, in regions of poor bone quality or previously infected sites, the clinical outcomes are more inconsistent. For that purpose, peptides have been added to particulate materials in an attempt to render them with antibacterial properties or to improve their osseoconductivity. For instance, competence-stimulating peptide (CSP) has been studied to decrease the division rate of Streptococcus mutans. Also, the addition of a specific short amino acid sequence peptide derived from type I collagen (P-15) to the bone substitutes has been introduced in an attempt to increase its osseoconductivity. The present study hypothesized that xenogeneic graft materials with and without CSP would present improved host-to-biomaterial response when used in combination with P-15. Particulate graft materials with and without P-15, OsteoGraf with CSP and OsteoGraf, were implanted in an 8-mm rabbit calvarial defect for 4 weeks, and thereafter, histological and histomorphometrical evaluation was performed. The results showed that both OsteoGraf and CSP groups with the addition of P-15 induced bone growth towards the center of the defect. Furthermore, the addition of CSP to Osteograf showed a tendency to increase its osteoconductivity when combined with P-15. The results of the current study suggested that P-15 had some impact on osteogenesis; however, the effect differed between different bone substitute materials. Further investigation is necessary to clarify its effectiveness when used in combination with bone substitutes.
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