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| 2. |
- Andersson Sundén, Erik, et al.
(författare)
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Evaluation of neutron spectrometer techniques for ITER using synthetic data
- 2013
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 701, s. 62-71
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Tidskriftsartikel (refereegranskat)abstract
- A neutron spectrometer at ITER is expected to provide estimates of plasma parameters such as ion temperature, Ti, fuel ion ratio, nt/nd, and Qthermal/Qtot, with 10-20% precision at a time resolution, Δt, of at least 100 ms. The present paper describes a method for evaluating different neutron spectroscopy techniques based on their instrumental response functions and synthetic measurement data. We include five different neutron spectrometric techniques with realistic response functions, based on simulations and measurements where available. The techniques are magnetic proton recoil, thin-foil proton recoil, gamma discriminating organic scintillator, diamond and time-of-flight. The reference position and line of sight of a high resolution neutron spectrometer on ITER are used in the study. ITER plasma conditions are simulated for realistic operating scenarios. The ITER conditions evaluated are beam and radio frequency heated and thermal deuterium-tritium plasmas. Results are given for each technique in terms of the estimated time resolution at which the parameter determination can be made within the required precision (here 10% for Ti and the relative intensities of NB and RF emission components). It is shown that under the assumptions made, the thin-foil techniques out-perform the other spectroscopy techniques in practically all measurement situations. For thermal conditions, the range of achieved Δt in the determination of Ti varies in time scales from ms (for the magnetic and thin-foil proton recoil) to s (for gamma discriminating organic scintillator).
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| 3. |
- Ballabio, Luigi, 1970-
(författare)
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Calculation and Measurement of the Neutron Emission Spectrum due to Thermonuclear and Higher-Order Reactions in Tokamak Plasmas
- 2003
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- A series of analytic and numerical models have been developed for the prediction and interpretation of the energy spectrum of the neutron emission from thermonuclear deuteriumtritium (DT) plasmas. The main component of the neutron emission, due to reactions between thermal fuel ions, has been modeled as well as minority components due to the presence of fast (supra-thermal) ions. In particular, the so-called alpha-particle knock-on neutron (AKN) emission has been analyzed and found to carry information on the con- finement of fast alpha particles inside the plasma. The alpha particles carry one fifth of the fusion power generated in the plasma and provide the plasma self-heating. This thesis is devoted to this central endeavor of fusion research and the possibilities for its study in today’s largest magnetic confinement devices, the tokamaks.The developed models have been used for the interpretation of experimental data taken during the first deuterium-tritium experiment (DTE1) at the Joint European Torus (JET) in 1997. The data were taken with a neutron spectrometer of the magnetic proton recoil (MPR) type developed at the Department of Neutron Research (INF) of Uppsala University. The MPR was used to measure the neutron emission from DT plasmas representing record high fusion power levels of up to 16 MW and correspondingly high quality in the neutron emission observations. These studies in DT plasmas were complemented with theoretical and empirical studies of the 14-MeV triton burn-up neutron (TBN) emission from deuterium plasmas.The predicted neutron energy spectra were found to be able to describe observations leading to positive identification of previously unobserved spectral features such as the very weak AKN and TBN signature in the neutron emission. In this summary, the developed models are presented as well as the experimental findings. Finally, a discussion is included of the possible application of the presented models and experimental techniques to next-step fusion experiments such as the proposed ITER tokamak.
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| 4. |
- Hellesen, Carl, 1980-, et al.
(författare)
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Neutron spectroscopy measurements and modeling of neutral beam heating fast ion dynamics
- 2010
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 52:8, s. 085013-
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Tidskriftsartikel (refereegranskat)abstract
- The energy spectrum of the neutron emission from beam-target reactions in fusion plasmas at the Joint European Torus (JET) has been investigated. Different beam energies as well as injection angles were used. Both measurements and simulations of the energy spectrum were done. The measurements were made with the time-of-flight spectrometer TOFOR. Simulations of the neutron spectrum were based on first-principle calculations of neutral beam deposition profiles and the fast ion slowing down in the plasma using the code NUBEAM, which is a module of the TRANSP package. The shape of the neutron energy spectrum was seen to vary significantly depending on the energy of the beams as well as the injection angle and the deposition profile in the plasma. Cross validations of the measured and modeled neutron energy spectra were made, showing a good agreement for all investigated scenarios.
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| 7. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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