| 1. |
- Garland, N. T., et al.
(författare)
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A Miniaturized, Battery-Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early
- 2023
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Ingår i: Advanced Healthcare Materials. - : Wiley. - 2192-2640 .- 2192-2659. ; 12:28
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Tidskriftsartikel (refereegranskat)abstract
- Diabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation and mortality, highlighting the critical need for their early detection. Recent demonstrations of wearable sensors enable real-time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery-free wound monitor that measures lactate in real-time and seamlessly integrates with bandages for conformal attachment to the wound bed is introduced. Lactate is selected due to its multifaceted role in initiating healing. Studies in healthy and diabetic mice reveal distinct lactate profiles for normal and impaired healing wounds. A mathematical model based on the sensor data predicts wound closure rate within the first 3 days post-injury with ≈76% accuracy, which increases to ≈83% when pH is included. These studies underscore the significance of monitoring biomarkers during the inflammation phase, which can offer several benefits, including short-term use of wound monitors and their easy removal, resulting in lower risks of injury and infection at the wound site. Improvements in prediction accuracy can be achieved by designing mathematical models that build on multiple wound parameters such as pro-inflammatory and metabolic markers. Achieving this goal will require designing multi-analyte wound monitors.
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| 2. |
- Huang, Ivy, et al.
(författare)
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High performance dual-electrolyte magnesium-iodine batteries that can harmlessly resorb in the environment or in the body
- 2022
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Ingår i: Energy & Environmental Science. - : Royal Society of Chemistry (RSC). - 1754-5692 .- 1754-5706. ; 15:10, s. 4095-4108
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Tidskriftsartikel (refereegranskat)abstract
- Batteries represent the dominant means for storing electrical energy, but many battery chemistries create waste streams that are difficult to manage, and most possess toxic components that limit their use in biomedical applications. Batteries constructed from materials capable of complete, harmless resorption into the environment or into living organisms after a desired period of operation bypass these disadvantages. However, previously reported eco/bioresorbable batteries offer low operating voltages and modest energy densities. Here, we introduce a magnesium-iodine chemistry and dual (ionic liquid/aqueous) electrolyte to overcome these limitations, enabling significant improvements in voltage, areal capacity, areal energy, areal power, volumetric energy, and volumetric power densities over any alternative. Systematic studies reveal key materials and design considerations. Demonstrations of this technology include power supplies for cardiac pacemakers, wireless environmental monitors, and thermal sensors/actuators. These results suggest strong potential for applications where commercial battery alternatives pose risks to the environment or the human body.
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