| 1. |
- Axberg, Stefan, et al.
(författare)
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Lärobok i Militärteknik, vol. 9 : Teori och metod
- 2013. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Ämnet militärteknik utgår från att tekniska system är officerens arbetsredskap och att en förståelse för och kunskap om dessa verktyg är central för att kunna utöva professionen framgångsrikt. Denna nionde volym av Lärobok i Militärteknik, benämnd Teori och Metod, behandlar centrala begrepp, teorier och postulat samt metoder för värdering av teknik och består av ett antal texter författade av 16 forskare och lärare vid den militärtekniska avdelningen. Volymen riktar sig främst till de som inlett sin officersutbildning och utgörs till stora delar av ett kompilat av publicerade och opublicerade militärtekniska texter och kan sägas utgöra militärteknikens ”state of the art”.
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| 2. |
- Bang, Martin
(författare)
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Military intelligence analysis : institutional influence
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Intelligence is vital for the outcome of battles. As long as humans wage war, there will be a need for decision support to military and civilian leaders regarding adversaries or potential adversaries. However, the production of intelligence is neither easy nor without pitfalls. There is a need to better understand the predicaments of intelligence analysis.Intelligence is bureaucratically produced as well as socially constructed and created in a distinct cultural context. The ‘institution’ captures these three aspects of influence. Therefore, with a particular focus on military intelligence, this thesis aims to deepen the understanding regarding institutional influence on intelligence assessments. The literature regarding intelligence has grown steadily over the last three decades. However, theories and frameworks aimed to understand the phenomenon are still sparse. This is even more true for literature regarding contemporary military intelligence. This thesis intends to contribute to bridging these research gaps. This is done by studying the Swedish military intelligence institution from several different perspectives: its rules-in-use, shared beliefs, and the incoming stimuli primarily related to conducting threat assessments.More precisely the thesis investigates the use of quantitative methods, doctrines (i.e. the formal rules), and shared beliefs connected to epistemological assumptions and threat assessments. The main contribution of this thesis is that it establishes and describes a casual link between a military intelligence institution and an assessment, by drawing upon rulesin-use and belief systems and their effect on the mental model and consequently the perception of the situation connected to a cognitive bias, and thereby its effect on a given assessment. The thesis makes an effort to render intelligence studies more generalizable, by way of adopting the Institutional Analysis and Development (IAD) framework. The metatheoretical language of the IAD is a promising avenue for explaining and describing the institutional influence on intelligence assessments.
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| 4. |
- d'Amore, Francesco, et al.
(författare)
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Phase II trial of zanolimumab (HuMax-CD4) in relapsed or refractory non-cutaneous peripheral T cell lymphoma
- 2010
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 150:5, s. 565-573
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Tidskriftsartikel (refereegranskat)abstract
- The efficacy and safety of zanolimumab (HuMax-CD4) in patients with relapsed or refractory peripheral T Cell lymphoma (PTCL) was evaluated. Twenty-one adult patients with relapsed or refractory CD4+ PTCL of non-cutaneous type (angioimmunoblastic T cell lymphoma (AITL) n = 9, PTCL-not otherwise specified (NOS) n = 7, anaplastic large cell lymphoma (ALCL) n = 4 and enteropathy type T cell lymphoma n = 1) were treated in a single-arm multi-centre study, with weekly intravenous infusions of zanolimumab 980 mg for 12 weeks. Median age was 69 years (range 26-85). Seventeen of the patients had advanced stage disease (Ann Arbor stages III-IV). Objective tumour responses were obtained in 24% of the patients with two complete responses unconfirmed (CRu) and three partial responses (PR). One of the CRus lasted more than 252 d. Responses were obtained in different PTCL entities: AITL (n = 3), ALCL (n = 1) and PTCL-NOS (n = 1). In general, the trial drug was well tolerated with no major toxicity. Zanolimumab at a dose of 980 mg weekly demonstrated clinical activity and an acceptable safety profile in this poor-prognosis patient population, suggesting that the potential benefit combining zanolimumab with standard chemotherapy in the treatment of PTCL should be investigated.
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| 6. |
- Ishigaki, Kazuyoshi, et al.
(författare)
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Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis
- 2022
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:11, s. 1640-1651
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Tidskriftsartikel (refereegranskat)abstract
- Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of polygenic risk scores (PRS). Here, we present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups. We conducted a multi-ancestry meta-analysis and identified 124 loci (P < 5 × 10−8), of which 34 are novel. Candidate genes at the novel loci suggest essential roles of the immune system (for example, TNIP2 and TNFRSF11A) and joint tissues (for example, WISP1) in RA etiology. Multi-ancestry fine-mapping identified putatively causal variants with biological insights (for example, LEF1). Moreover, PRS based on multi-ancestry GWAS outperformed PRS based on single-ancestry GWAS and had comparable performance between populations of European and East Asian ancestries. Our study provides several insights into the etiology of RA and improves the genetic predictability of RA.
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