| 1. |
- Aad, G., et al.
(författare)
-
- 2012
-
swepub:Mat__t (refereegranskat)
|
|
| 2. |
- Abazajian, Kevork, et al.
(författare)
-
CMB-S4 : Forecasting Constraints on Primordial Gravitational Waves
- 2022
-
Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 926:1
-
Tidskriftsartikel (refereegranskat)abstract
- CMB-S4—the next-generation ground-based cosmic microwave background (CMB) experiment—is set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the universe. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semianalytic projection tool, targeted explicitly toward optimizing constraints on the tensor-to-scalar ratio, r, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2–3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments, given a desired scientific goal. To form a closed-loop process, we couple this semianalytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for r > 0.003 at greater than 5σ, or in the absence of a detection, of reaching an upper limit of r < 0.001 at 95% CL.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Bard-Chapeau, Emilie A, et al.
(författare)
-
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects
- 2014
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:2
-
Tidskriftsartikel (refereegranskat)abstract
- The ecotropic viral integration site 1 (Evi1) oncogenic transcription factor is one of a number of alternative transcripts encoded by the Mds1 and Evi1 complex locus (Mecom). Overexpression of Evi1 has been observed in a number of myeloid disorders and is associated with poor patient survival. It is also amplified and/or overexpressed in many epithelial cancers including nasopharyngeal carcinoma, ovarian carcinoma, ependymomas, and lung and colorectal cancers. Two murine knockout models have also demonstrated Evi1's critical role in the maintenance of hematopoietic stem cell renewal with its absence resulting in the death of mutant embryos due to hematopoietic failure. Here we characterize a novel mouse model (designated Evi1(fl3)) in which Evi1 exon 3, which carries the ATG start, is flanked by loxP sites. Unexpectedly, we found that germline deletion of exon3 produces a hypomorphic allele due to the use of an alternative ATG start site located in exon 4, resulting in a minor Evi1 N-terminal truncation and a block in expression of the Mds1-Evi1 fusion transcript. Evi1(δex3/δex3) mutant embryos showed only a mild non-lethal hematopoietic phenotype and bone marrow failure was only observed in adult Vav-iCre/+, Evi1(fl3/fl3) mice in which exon 3 was specifically deleted in the hematopoietic system. Evi1(δex3/δex3) knockout pups are born in normal numbers but die during the perinatal period from congenital heart defects. Database searches identified 143 genes with similar mutant heart phenotypes as those observed in Evi1(δex3/δex3) mutant pups. Interestingly, 42 of these congenital heart defect genes contain known Evi1-binding sites, and expression of 18 of these genes are also effected by Evi1 siRNA knockdown. These results show a potential functional involvement of Evi1 target genes in heart development and indicate that Evi1 is part of a transcriptional program that regulates cardiac development in addition to the development of blood.
|
|
| 6. |
- Bard, D., et al.
(författare)
-
A finite element solution of structure-borne sound attenuation for a lightweight timber floor
- 2008
-
Ingår i: Building Acoustics. - : SAGE Publications. - 1351-010X .- 2059-8025. ; 15:2, s. 137-152
-
Tidskriftsartikel (refereegranskat)abstract
- Structure-borne sound attenuation of lightweight timber floor structures has been investigated by high-resolution numerical calculation methods. Two models have been studied both experimentally and numerically. The first considers a continuous chipboard plate and a supporting beam. The second considers two plates that are fastened on one beam. Damping effects, which arise from the two different discontinuities, are included. The real-valued modulus of elasticity is replaced with a complex value. In the calculations, the orthotropic material characteristics of the building material have also been taken into account. The results from the calculations and laboratory measurement confirm that the attenuation rate is highly dependent on the excitation location, if all the other parameters remain the same.
|
|
| 7. |
- Bard, D., et al.
(författare)
-
Field measurements of the Mobility and Vibrations induced by human walking on a wooden floor
- 2010
-
Ingår i: 39th International Congress on Noise Control Engineering 2010, INTER-NOISE 2010. - 9781617823961 ; 1, s. 289-297
-
Konferensbidrag (refereegranskat)abstract
- Lightweight constructions of timber material are cost effective and demands relatively short production duration. One of the main drawbacks of lightweight structures, however, is related to the sound transmission. More and more complains arise against this type of structures, related to the propagation of low frequency vibrations induced by human activities. Most problems are caused by human walking, more exactly foot impacts, which generate a harmonic force whose frequency is close to the natural frequency of the floor. This investigation is focused on measurements of induced walking vibrations with real human walking and the mobility; those were performed on an in-situ wooden floor. The measurements of accelerations induced by a walking person were used to evaluate existing vibration criteria.
|
|
| 8. |
- Bard, D., et al.
(författare)
-
Vibrations analysis in high-tech facility : A swedish light synchrotron
- 2010
-
Ingår i: 17th International Congress on Sound and Vibration 2010 : ICSV 17 - ICSV 17. - 9781617822551 ; 4, s. 2811-2818
-
Konferensbidrag (refereegranskat)abstract
- MAX-lab is a national laboratory operated jointly by the Swedish Research Council and Lund University. As of today, the MAX project consists of three facilities, (three storage rings): MAX-I, MAX-II, MAX-III and one electron pre-accelerator called MAX-Injector. A new storage ring is needed at the benefit of material science, such as nanotechnology. MAX-IV will be 100 times more efficient than existing synchrotron radiation facilities. MAX-IV will consist of a main source that will be a 3-GeV ring with state-of-the-art low emittance for the production of soft and hard x-rays as well as an expansion into the free electron laser field. The second source, the Linac injector, will provide short pulses to a short pulse facility. It will be built as an underground tunnel next to the main ring. The main objective of the present work is to study vibrations at the foundation of the light synchrotron subjected to different excitations and analyze the influence of the surrounding vibration sources on the MAX-IV Lab's underground tunnel. Since MAX-IV will be used for high precision measurements, it will be asked to have very strict technical conditions where only very low vibration levels will be allowed. The aim is to establish realistic finite element models that predict vibrations in the foundation and in the Linac with high accuracy. To achieve this purpose it will be necessary to model loads, materials, etc. with different assumptions, in order to prove the fulfillment of the needed requirements. The vibrations are analyzed by the finite element method in both transient and steady state solutions. The ring model contains the concrete floor structure, the concrete structure of the beam containment and the soil up to a depth of about 10m and extending to the nearby roads, while Linac's model has the tunnel itself, the soil (up to 10 m deep also) and the crossing bridge over it.
|
|
| 9. |
|
|
| 10. |
|
|
