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Sökning: WFRF:(Barghi Hamidreza)

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1.
  • Alizadeh, R., et al. (författare)
  • Synthesis of Depo-Medrol-chitosan hydrogel as new drug slow-release appliance and investigation of release kinetics by high-performance liquid chromatography
  • 2016
  • Ingår i: Biomedical Chromatography. - : Wiley. - 1099-0801 .- 0269-3879. ; 30:9, s. 1346-1353
  • Tidskriftsartikel (refereegranskat)abstract
    • The present study deals with preparation and optimization of a novel chitosan hydrogel-based matrix by suspension cross-linking method for controlled release of Depo-Medrol. The controlled release of Depo-Medrol for effective Rheumatoid arthritis disease has become an imperative field in the drug delivery system. In this context, it was intended to optimize loading circumstances by experimental design and also study the release kinetics of Depo-Medrol entrapped in the chitosan matrix in order to obtain maximal efficiency for drug loading. The optimum concentrations of chitosan (2.5g), glutaraldehyde (3.05L) and Depo-Medrol (0.1mg) were set up to achieve the highest value of drug loaded and the most sustained release from the chitosan matrix. In vitro monitoring of drug release kinetic using high-performance liquid chromatography showed that 73% of the Depo-Medrol was released within 120min, whereas remained drug was released during the next 67h. High correlation between first-order and Higuchi's kinetic models indicates a controlled diffusion of Depo-Medrol through the surrounding media. Moreover, recovery capacity >82% and entrapment efficiency of 58-88% were achieved under optimal conditions. Therefore, the new synthesized Depo Medrol-chitosan is an applicable appliance for therapy by slow release mechanism.
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2.
  • Barghi, Hamidreza, et al. (författare)
  • Bulk Hydrophilic Functionalization of Polyamide 46
  • 2013
  • Patent (populärvet., debatt m.m.)abstract
    • (EN)A modified polymer as result of a bulk functionalization of polyamide 46 (PA 46) is presented, as well as methods for synthesizing the modified polymer. This functionalization of PA 46 is performed to provide a homogenous semi-permeable polyamide 46 capable of different charges and different porosities with particles of nanoscale size in order to replace or improve other polyamide fibers used in the textile industry, filtering processes, selective sorption, controlled release devices, phase transfer catalysts, chromatography media, biocompatible capsules, artificial skins, organs, bone void repair as well as in cell bioreactors and incubators, dental impliments, medical devices, clothing, detectors, perfusion devices, in regenerative medicine, and fuel cells. (FR)Un polymère modifié comme résultat d'une fonctionnalisation en masse de polyamide 46 (PA 46) est présenté, ainsi que des procédés de synthèse du polymère modifié. Cette fonctionnalisation de PA 46 est effectuée pour fournir un polyamide 46 semi-perméable homogène apte à des différentes charges et de différentes porosités avec des particules d'une dimension à l'échelle nanométrique afin de remplacer ou d'améliorer d'autres fibres de polyamide utilisées dans l'industrie textile, les procédés de filtration, la sorption sélective, les dispositifs à libération entretenue, les catalyseurs de transfert de phase, les supports de chromatographie, les capsules biocompatibles, les peaux artificielles, les organes, la réparation de cavités osseuses ainsi que les bioréacteurs et incubateurs de cellules, les implants dentaires, les dispositifs médicaux, les vêtements, les détecteurs, les dispositif de perfusion, en médecine régénérative et dans les piles à combustible.
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3.
  • Barghi, Hamidreza, 1970, et al. (författare)
  • BULK HYDROPHILIC FUNTIONALIZATION OF POLYAMIDE 46
  • 2013
  • Patent (övrigt vetenskapligt/konstnärligt)abstract
    • A modified polymer as result of a bulk functionalization of polyamide 46 (PA 46) is presented, as well as methods for synthesizing the modified polymer. This functionalization of PA 46 is performed to provide a homogenous semi-permeable polyamide 46 capable of different charges and different porosities with particles of nanoscale size in order to replace or improve other polyamide fibers used in the textile industry, filtering processes, selective sorption, controlled release devices, phase transfer catalysts, chromatography media, biocompatible capsules, artificial skins, organs, bone void repair as well as in cell bioreactors and incubators, dental impliments, medical devices, clothing, detectors, perfusion devices, in regenerative medicine, and fuel cells.
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4.
  • Barghi, Hamidreza, 1970, et al. (författare)
  • Catalytic Synthesis of Bulk Hydrophilic Acetaldehyde-Modified Polyamide 46
  • 2014
  • Ingår i: Current Organic Synthesis. - : Bentham Science Publishers Ltd.. - 1570-1794 .- 1875-6271. ; 11:2, s. 288-294
  • Tidskriftsartikel (refereegranskat)abstract
    • Hydrophilization of Polyamide 46 (PA46) via modification with acetaldehyde in continuous phase was studied. The chemical modification of PA 46 with acetaldehyde resulted in a water-swollen polymer with hydrophilic property. The polyamide 46 undergoes a nucleophilic addition with acetaldehyde in the presence of aluminum chloride as a catalyst. The extent of bulk hydroxyethylation using AlCl3 resulted in 95.65% modification counted as total N-hydroxyethylated polyamide 46. The modification resulted in improved hydrophilic properties, and a maximum surface free energy of 44.6 mJ/m2 was achieved after 3 h reaction, whereas the unmodified PA46 had a surface free energy of 11.2 mJ/m2. In addition, thermal properties of the polymers were studied using differential scanning calorimetry and thermogravimetric analyses. The functionalization leads to decrease in the crystallization energy from 88 J/g to 51 J/g, while the melting energy is changed from 110 J/g to 53 J/g. Furthermore, the thermal stability of the PA46 to pyrolysis was diminished after hydroxylation.
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5.
  • Barghi, Hamidreza (författare)
  • Functionalization of Synthetic Polymers for Membrane Bioreactors
  • 2014
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Membrane bioreactors (MBRs) show great promise for productivity improvement and energy conservation in conventional bioprocesses for wastewater reclamation. In order to attain high productivity in a bioprocess, it is crucial to retain the microorganisms in the bioreactors by preventing wash out. This enables recycling of the microorganisms, and is consequently saving energy. The main feature of MBRs is their permeable membranes, acting as a limitative interface between the medium and the microorganisms. Permeation of nutrients and metabolites through the membranes is thus dependent on the membrane characteristics, i.e. porosity, hydrophilicity,and polarity. The present thesis introduces membranes for MBRs to be used in a continuous feeding process, designed in the form of robust, durable, and semi-hydrophilic films that constitute an effective barrier for the microorganisms, while permitting passage of nutrients and metabolites. Polyamide 46 (polytetramethylene adipamide), a robust synthetic polymer, holds the desired capabilities, with the exception of porosity and hydrophilicity. In order to achieve adequate porosity and hydrophilicity, bulk functionalization of polyamide 46 with different reagents was performed. These procedures changed the configuration from dense planar to spherical, resulting in increased porosity. Hydroxyethylation of the changed membranes increased the surface tension from 11.2 to 44.6 mJ/m2. The enhanced hydrophilicity of PA 46 resulted in high productivity of biogas formation in a compact MBR, due to diminished biofouling. Copolymerization of hydrophilized polyamide 46 with hydroxymethyl 3,4-ethylenedioxythiophene revealed electroconductivity and hydrophilic properties, adequate for use in MBRs. To find either the maximal pH stability or the surface charge of the membranes having undergone carboxymethylation, polarity and the isoelectric point (pI) of the treated membranes were studied by means of a Zeta analyzer. The hydroxylated PA 46 was finally employed in a multilayer membrane bioreactor and compared with hydrophobic polyamide and PVDF membranes. The resulting biogas production showed that the hydroxylated PA 46 membrane was, after 18 days without regeneration, fully comparable with PVDF membranes.
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8.
  • Barghi, Hamidreza, 1970, et al. (författare)
  • Synthesis of an electroconductive membrane using poly(hydroxymethyl-3,4-ethylenedioxythiophene-co-tetramethylene-N-hydrox yethyl adipamide)
  • 2013
  • Ingår i: Journal of Materials Chemistry C. - : Royal Society of Chemistry (RSC). - 2050-7534 .- 2050-7526. ; 1:39, s. 6347-6354
  • Tidskriftsartikel (refereegranskat)abstract
    • Synthesis of a novel electroconductive membrane (ECM) was studied with the aim of producing an electroconductive membrane (ECM) with low electrical resistance and appropriate mechanical properties. The method was based on copolymerization of a highly electroconductive monomer (hydroxymethyl-3,4-ethylenedioxythiophene) with highly mechanical resistant hydrophilized polyamide 46 (polytetramethylene-N-hydroxyethyl adipamide). Due to the lack of hydroxyl groups, polyamide 46 does not have the tendency to take part in any chemical reactions, therefore prior to copolymerization, PA 46 was hydrophilized with acetaldehyde to create reactive sites, which allowed copolymerization to occur. At the final stage, a very thin layer, 566 nm conductive poly(hydroxymethyl-3,4-ethylenedioxythiophene) homopolymer was localised using in situ plasma polymerization in order to improve the electrical conductivity of the obtained copolymer. The result was an adherent, highly conductive, semi-hydrophilic and flexible ECM. The presence of hydroxyl groups in the final product led to improved hydrophilicity of the conductive membrane with a surface tension of 41 mJ m(-2). The electrical resistance of PA 46 was dramatically reduced after copolymerization, to 202 in dry and 54 k Omega cm(-2) in wet conditions; furthermore, after plasma treatment, this reduction continued to 105 in dry and 2 k Omega cm(-2) in wet conditions. Other parameters such as flux flow, roughness, pore size, pore distribution, contact angle, surface energy and thermal stability of the ECM were also investigated.
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9.
  • Majdejabbari, Sara, et al. (författare)
  • Synthesis and Characterization of Biosuperabsorbent Based on Ovalbumin Protein
  • 2010
  • Ingår i: Journal of macromolecular science. Pure and applied chemistry (Print). - : Informa UK Limited. - 1060-1325 .- 1520-5738. ; 47:7, s. 708-715
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • A biosuperabsorbent (Bio-SAP) hydrogel from ovalbumin (egg protein) was synthesized via modification with an acylating reagent and a bifunctional crosslinker, and its swelling behavior was investigated. The protein was acylated using ethylenediaminetetraacetic dianhydride (EDTAD), and then crosslinked by glutaraldehyde and dried. Bio-SAP provided through this method includes modification of lysyl residues in the unfolded protein by adding one or more hydrophilic carboxyl groups to increase the hydrophilicity of protein. The water binding capacity was measured in deionized water, 0.9% NaCl solution and synthetic urine, which under the best conditions were 296, 64 and 56 g/g after 24 h, respectively. In addition, the effects of EDTAD/protein ratio on the chemical modification of the protein, the various chemical neutralization agents, pH sensitivity and ionic strength, as well as temperature and particle size on the water absorption capacity with and without load and its kinetic were also investigated.
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10.
  • Majdejabbari, Sara, et al. (författare)
  • Synthesis and Properties of a Novel Biosuperabsorbent from Alkali Soluble Rhizomucor pusillus Proteins
  • 2011
  • Ingår i: Applied Microbiology and Biotechnology. - : Springer. - 0175-7598 .- 1432-0614. ; 92:6, s. 1171-1177
  • Tidskriftsartikel (refereegranskat)abstract
    • A novel biosuperabsorbent protein hydrogel was prepared from protein-rich alcoholic–alkali soluble parts of zygomycete Rhizomucor pusillus biomass. The fungal protein content was 46.8%, and the lipid content was 13.1%. Extraction of protein from this microorganism through the method applied prevents protein decomposition, resulting in maximum yield. After alcoholic–alkaline extraction, the proteins from the biomass were acylated using ethylenediaminetetraacetic dianhydride and subsequently treated with glutaraldehyde as a crosslinker for further experiments. Thermal consistency was investigated by means of two different methods: thermal denaturation via differential scanning calorimetry and thermal decomposition study via thermogravimetric analysis. The swelling behaviour of the crosslinked hydrogel was measured in deionised water, 0.9% NaCl solution and synthetic urine, which were 87.6, 43 and 38.6 g/g water after 24 h, respectively. Moreover, the isoelectric point (pI) of the hydrogel was determined as pH = 8 by studying swelling behaviour at different pHs. In addition, the dependencies of the swelling behaviour with regard to the chemical modification, the ionic strength, the degree of crosslinking, as well as water absorbency with or without load were studied.
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