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Sökning: WFRF:(Barletta J)

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  • Beyer, Katharina, et al. (författare)
  • Diagnostic and prognostic factors in patients with prostate cancer : a systematic review
  • 2022
  • Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 12:4
  • Forskningsöversikt (refereegranskat)abstract
    • Objectives As part of the PIONEER Consortium objectives, we have explored which diagnostic and prognostic factors (DPFs) are available in relation to our previously defined clinician and patient-reported outcomes for prostate cancer (PCa). Design We performed a systematic review to identify validated and non-validated studies. Data sources MEDLINE, Embase and the Cochrane Library were searched on 21 January 2020. Eligibility criteria Only quantitative studies were included. Single studies with fewer than 50 participants, published before 2014 and looking at outcomes which are not prioritised in the PIONEER core outcome set were excluded. Data extraction and synthesis After initial screening, we extracted data following the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of prognostic factor studies (CHARMS-PF) criteria and discussed the identified factors with a multidisciplinary expert group. The quality of the included papers was scored for applicability and risk of bias using validated tools such as PROBAST, Quality in Prognostic Studies and Quality Assessment of Diagnostic Accuracy Studies 2. Results The search identified 6604 studies, from which 489 DPFs were included. Sixty-four of those were internally or externally validated. However, only three studies on diagnostic and seven studies on prognostic factors had a low risk of bias and a low risk concerning applicability. Conclusion Most of the DPFs identified require additional evaluation and validation in properly designed studies before they can be recommended for use in clinical practice. The PIONEER online search tool for DPFs for PCa will enable researchers to understand the quality of the current research and help them design future studies. Ethics and dissemination There are no ethical implications.
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  • Salehi, Hamid, et al. (författare)
  • The role of particle size and other properties on silo discharge behaviour of chipped wood biomass
  • 2024
  • Ingår i: Powder Technology. - : Elsevier. - 0032-5910 .- 1873-328X. ; 432
  • Tidskriftsartikel (refereegranskat)abstract
    • To achieve net-zero carbon emissions by 2050, the UK government emphasizes the pivotal role of sustainable bioenergy in electricity, transportation, and heating. However, challenges persist in handling biomass particulate solids in production facilities, leading to economic impacts. This study investigates the flow characteristics of stemwood chips from four tree species using a novel drum chipper. Experimental analyses include bulk density measurements, silo discharge studies, biomass flow property assessments, and wall friction measurements. Comparative analyses are performed using Jenike's procedure for building wedge-shaped silos, with a focus on predicting the critical opening size to prevent arching. Additionally, the paper delves into the creation of statistical models aimed at identifying key factors influencing the flow behaviour during silo discharge. Emphasis is placed on understanding potential discrepancies between theoretical predictions and experimental results concerning critical silo openings for arch-free discharge. The results contribute to understanding the factors influencing the flow behaviour of wood chips, informing silo design considerations. Our findings suggest limitations in applying traditional silo design methods, urging further research for more accurate predictions.
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