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- Spada, G., et al.
(författare)
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A benchmark study for glacial isostatic adjustment codes
- 2011
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Ingår i: Geophysical Journal International. - 0956-540X .- 1365-246X. ; 185:1, s. 106-132
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Tidskriftsartikel (refereegranskat)abstract
- The study of glacial isostatic adjustment (GIA) is gaining an increasingly important role within the geophysical community. Understanding the response of the Earth to loading is crucial in various contexts, ranging from the interpretation of modern satellite geodetic measurements (e. g. GRACE and GOCE) to the projections of future sea level trends in response to climate change. Modern modelling approaches to GIA are based on various techniques that range from purely analytical formulations to fully numerical methods. Despite various teams independently investigating GIA, we do not have a suitably large set of agreed numerical results through which the methods may be validated; a community benchmark data set would clearly be valuable. Following the example of the mantle convection community, here we present, for the first time, the results of a benchmark study of codes designed to model GIA. This has taken place within a collaboration facilitated through European Cooperation in Science and Technology (COST) Action ES0701. The approaches benchmarked are based on significantly different codes and different techniques. The test computations are based on models with spherical symmetry and Maxwell rheology and include inputs from different methods and solution techniques: viscoelastic normal modes, spectral-finite elements and finite elements. The tests involve the loading and tidal Love numbers and their relaxation spectra, the deformation and gravity variations driven by surface loads characterized by simple geometry and time history and the rotational fluctuations in response to glacial unloading. In spite of the significant differences in the numerical methods employed, the test computations show a satisfactory agreement between the results provided by the participants.
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- Allaria, E., et al.
(författare)
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Highly coherent and stable pulses from the FERMI seeded free-electron laser in the extreme ultraviolet
- 2012
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Ingår i: Nature Photonics. - 1749-4885. ; 6:10, s. 699-704
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Tidskriftsartikel (refereegranskat)abstract
- Free-electron lasers (FELs) are promising devices for generating light with laser-like properties in the extreme ultraviolet and X-ray spectral regions. Recently, FELs based on the self-amplified spontaneous emission (SASE) mechanism have allowed major breakthroughs in diffraction and spectroscopy applications, despite the relatively large shot-to-shot intensity and photon-energy fluctuations and the limited longitudinal coherence inherent in the SASE mechanism. Here, we report results on the initial performance of the FERMI seeded FEL, based on the high-gain harmonic generation configuration, in which an external laser is used to initiate the emission process. Emission from the FERMI FEL-1 source occurs in the form of pulses carrying energy of several tens of microjoules per pulse and tunable throughout the 65 to 20 nm wavelength range, with unprecedented shot-to-shot wavelength stability, low-intensity fluctuations, close to transform-limited bandwidth, transverse and longitudinal coherence and full control of polarization.
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- Barletta, V, et al.
(författare)
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Quantitative 7-Tesla Imaging of Cortical Myelin Changes in Early Multiple Sclerosis
- 2021
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Ingår i: Frontiers in neurology. - : Frontiers Media SA. - 1664-2295. ; 12, s. 714820-
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Tidskriftsartikel (refereegranskat)abstract
- Cortical demyelination occurs early in multiple sclerosis (MS) and relates to disease outcome. The brain cortex has endogenous propensity for remyelination as proven from histopathology study. In this study, we aimed at characterizing cortical microstructural abnormalities related to myelin content by applying a novel quantitative MRI technique in early MS. A combined myelin estimation (CME) cortical map was obtained from quantitative 7-Tesla (7T) T2* and T1 acquisitions in 25 patients with early MS and 19 healthy volunteers. Cortical lesions in MS patients were classified based on their myelin content by comparison with CME values in healthy controls as demyelinated, partially demyelinated, or non-demyelinated. At follow-up, we registered changes in cortical lesions as increased, decreased, or stable CME. Vertex-wise analysis compared cortical CME in the normal-appearing cortex in 25 MS patients vs. 19 healthy controls at baseline and investigated longitudinal changes at 1 year in 10 MS patients. Measurements from the neurite orientation dispersion and density imaging (NODDI) diffusion model were obtained to account for cortical neurite/dendrite loss at baseline and follow-up. Finally, CME maps were correlated with clinical metrics. CME was overall low in cortical lesions (p = 0.03) and several normal-appearing cortical areas (p < 0.05) in the absence of NODDI abnormalities. Individual cortical lesion analysis revealed, however, heterogeneous CME patterns from extensive to partial or absent demyelination. At follow-up, CME overall decreased in cortical lesions and non-lesioned cortex, with few areas showing an increase (p < 0.05). Cortical CME maps correlated with processing speed in several areas across the cortex. In conclusion, CME allows detection of cortical microstructural changes related to coexisting demyelination and remyelination since the early phases of MS, and shows to be more sensitive than NODDI and relates to cognitive performance.
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