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- Jimenez, Antonio M. Jimenez, et al.
(författare)
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An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis
- 2021
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Ingår i: Bone Marrow Transplantation. - : Springer Nature. - 0268-3369 .- 1476-5365. ; 56:12, s. 3068-3077
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Tidskriftsartikel (refereegranskat)abstract
- Cytogenetic and molecular abnormalities are known to influence post-transplant outcomes in acute myeloid leukemia (AML) but data assessing the prognostic value of combined genetic models in the HCT setting are limited. We developed an adapted European LeukemiaNet (aELN) risk classification based on available genetic data reported to the Center for International Blood and Marrow Transplant Research, to predict post-transplant outcomes in 2289 adult AML patients transplanted in first remission, between 2013 and 2017. Patients were stratified according to aELN into three groups: favorable (Fav, N = 181), intermediate (IM, N = 1185), and adverse (Adv, N = 923). Univariate analysis demonstrated significant differences in 2-year overall survival (OS) (Fav: 67.7%, IM: 64.9% and Adv: 53.9%; p < 0.001); disease-free survival (DFS) (Fav: 57.8%, IM: 55.5% and Adv: 45.3; p < 0.001) and relapse (Fav: 28%, IM: 27.5% and Adv: 37.5%; p < 0.001). Multivariate analysis (MVA) revealed no differences in outcomes between the Fav and IM groups, thus they were combined. On MVA, patients in the Adv risk group had the highest risk of relapse (HR 1.47 p <= 0.001) and inferior DFS (HR 1.35 p < 0.001) and OS (HR 1.39 p < 0.001), even using myeloablative conditioning or in those without the pre-HCT measurable-residual disease. Novel approaches to mitigate relapse in this high-risk group are urgently needed.
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- Papadogiannakis, Seméli, 1989-
(författare)
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Properties of Type Ia Supernovae : From the (intermediate) Palomar Transient Factory
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Type Ia Supernovae (SNe) have been used to discover the accelerated expansion of the universe but many open questions remain unanswered. These include the stellar progenitor, extinction and possible systematic trends in the supernova brightness for different host galaxy environments or cosmic time. In this thesis we attempt to address these open questions by looking at a large homogeneous sample of nearby SNe from the Palomar Transient Factory (2009-2012) and the intermediate Palomar Transient Factory (2013-2017) for which we have 265 well-observed light-curves in the R-band and 2981 spectra from a total of 2060 SNe.In Paper I we study the global properties of the R-band light-curves, such as rise-time, stretch and intrinsic brightness at different SN phases, to examine if there are multiple populations in any of the parameters suggesting different progenitor channels. We do not find evidence supporting this. We characterize the second maximum in the R-band in Paper II and find a correlation between the time from light-curve maximum, and the "colour-stretch" parameter, a proxy for 56Ni mass. We also found that the integrated flux under the second maximum, correlates with the transparency timescale, a proxy for total ejecta mass. Using these two relations we find that sub-Chandrasekhar double detonation models can account for the biggest fraction of the PTF/iPTF SNe light-curves properties. In Paper III we present the spectroscopic sample of PTF/iPTF and using automatic machine learning tools to explore spectral features and possible connection to photometric and host galaxy properties.Paper IV focuses on a small sample of SNe, with multi-wavelength light-curves, to address one of the most important systematic uncertainties in supernova cosmology: extinction by dust in the line-of-sights. We found a diversity in the reddening laws as characterised by the total-to-selective extinction, RV. Finally, Paper V looks at a strongly lensed SNIa at z=1.4 to see if there is evolution of its spectral and photometric properties over cosmic time. Both Paper IV and Paper V use the code developed for Paper III to analyse spectra.
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- Yu, He, et al.
(författare)
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Palaeogenomic analysis of black rat (Rattus rattus) reveals multiple European introductions associated with human economic history
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- The distribution of the black rat (Rattus rattus) has been heavily influenced by its association with humans. The dispersal history of this non-native commensal rodent across Europe, however, remains poorly understood, and different introductions may have occurred during the Roman and medieval periods. Here, in order to reconstruct the population history of European black rats, we first generate a de novo genome assembly of the black rat. We then sequence 67 ancient and three modern black rat mitogenomes, and 36 ancient and three modern nuclear genomes from archaeological sites spanning the 1st-17th centuries CE in Europe and North Africa. Analyses of our newly reported sequences, together with published mitochondrial DNA sequences, confirm that black rats were introduced into the Mediterranean and Europe from Southwest Asia. Genomic analyses of the ancient rats reveal a population turnover in temperate Europe between the 6th and 10th centuries CE, coincident with an archaeologically attested decline in the black rat population. The near disappearance and re-emergence of black rats in Europe may have been the result of the breakdown of the Roman Empire, the First Plague Pandemic, and/or post-Roman climatic cooling. 'Archaeogenetic analysis of black rat remains reveals that this species was introduced into temperate Europe twice, in the Roman and medieval periods. This population turnover was likely associated with multiple historical and environmental factors.'
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