| 1. |
- Florén, Henrik, et al.
(author)
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Additive manufacturing technologies and business models – a systematic literature review
- 2020
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In: Journal of Manufacturing Technology Management. - Bingley : Emerald Group Holdings Ltd.. - 1741-038X .- 1758-7786. ; 32:1, s. 136-155
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Research review (peer-reviewed)abstract
- Purpose: This paper reviews research on the intersection between additive manufacturing technologies (AMTs) and business models (BM). The purpose of the review is to synthesize past research for the benefit of researchers, to describe the dominant research themes and aggregated research questions and to identify research gaps in the literature. Design/methodology/approach: A systematic literature review of secondary data was conducted. The 288 publications in the review appeared in peer-reviewed journal articles, conference proceedings papers and book chapters. All publications are listed in this paper by publication year and publication source. The review also distinguishes between empirical and non-empirical studies, describes methodological approaches and categorizes the publications by unit of analysis and by theme. Findings: Research on the intersection between AMT and BM, which has increased significantly in the last three years, reflects firms' and industries' growing interest in digital manufacturing processes. This review identifies twelve dominant themes in the literature that contribute important insights to the field. Aggregated research questions are identified in each theme. Research advances and gaps are presented. Four themes relate directly to BM: (1) BM types, (2) BM and technology, (3) BM design and processes and (4) BM value and supply chains. Originality/value: This review is the first systematic literature review on the intersection between AMT and BM. As such, the review provides a guide for researchers as they explore gaps in the research and develop research questions on an aggregated level. The review also supports users of such technologies as they review their business practices and models in the so-called Digital Revolution.
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| 3. |
- Hörte, Sven-Åke, et al.
(author)
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Product Development in SMEs : A literature review
- 2008
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In: International Journal of Technology Intelligence and Planning (IJTIP). - Olney : InderScience Publishers. - 1740-2832 .- 1740-2840. ; 4:3, s. 299-325
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Journal article (peer-reviewed)abstract
- Product Development (PD) in Small and medium-sized Firms (SMEs) is a long-neglected research area, and little cumulative work has been conducted previously. The purpose of this paper is to provide a first overview of the area of PD in SMEs. In doing so, we draw upon a sample of 149 peer-reviewed research papers selected from an initial sample of 5694 papers. The review provides tentative answers to issues such as the analytical and methodological approaches of the papers, which topics or areas of research have been focused on by previous scholars, and what kinds of topics that are well covered.
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| 4. |
- Hörte, Sven-åke, et al.
(author)
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Product development in SMEs : an overview and tentative results
- 2008
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In: International Journal of Technology Intelligence and Planning (IJTIP). - 1740-2832 .- 1740-2840. ; 4:3, s. 299-325
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Journal article (peer-reviewed)abstract
- Product Development (PD) in Small and Medium-sized Firms (SMEs) is a long-neglected research area, and little cumulative work has been conducted previously. The purpose of this paper is to provide a first overview of the area of PD in SMEs. In doing so, we draw upon a sample of 149 peer-reviewed research papers selected from an initial sample of 5694 papers. The review provides tentative answers to issues such as the analytical and methodological approaches of the papers, which topics or areas of research have been focused on by previous scholars, and what kinds of topics that are well covered.
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| 6. |
- Barth, Henrik, et al.
(author)
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A cross-linked hyaluronic acid hydrogel (Healaflow(®)) as a novel vitreous substitute
- 2016
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In: Graefe's Archives for Clinical and Experimental Ophthalmology. - : Springer. - 0721-832X .- 1435-702X. ; 254:4, s. 697-703
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Journal article (peer-reviewed)abstract
- Purpose: Vitrectomy requires the substitution of the natural vitreous, as well as tamponading of retinal breaks. Clinically available alternatives such as gas and silicone oil have side effects such as inflammation, secondary glaucoma, cataract, and a need for head posturing. In this study, a hydrogel of cross-linked sodium hyaluronic acid (Healaflow(®)) is evaluated for use as a novel vitreous substitute.Methods: A combined 25-20-gauge pars plana vitrectomy with posterior vitreous detachment was performed in the right eye of twelve pigmented rabbits, with subsequent injection of approximately 1 ml Healaflow(®). Clinical evaluation, measurement of intraocular pressure (IOP), and full-field ERG were performed postoperatively. The rabbits were sacrificed at different time-points between 42 and 105 days. After enucleation, the eyes were examined macroscopically, photographed, and prepared for histological examination with routine microscopy and immunohistochemistry.Results: Healaflow(®) was successfully used with standard surgical procedures and remained translucent but did lose most of its viscosity during the postoperative period. One rabbit was lost due to unrelated causes. In two eyes iatrogenic partial retinal detachments were seen, and in two eyes significant cataract developed due to intra-operative complications. ERG-recordings revealed no toxic effect on rod or cone function. Routine microscopy and immunohistochemistry demonstrated normal morphology with some Müller cell activation (up-regulation of glial acidic fibrillary protein, GFAP) compared to unoperated eyes and no significant DNA-fragmentation (TUNEL-assay).Conclusions: Healaflow® did not affect retinal morphology or function negatively during long-term use as a vitreous substitute, making it highly interesting in this setting. An estimated retention time of a few weeks suggests potential for use as a short-term tamponade. Future work will include an increased ratio of cross-linking to prolong the structural integrity of the gel.
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| 7. |
- Barth, Henrik, 1971-, et al.
(author)
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A Green Lean approach to global competition and climate change in the agricultural sector – A Swedish case study
- 2018
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In: Journal of Cleaner Production. - Amsterdam : Elsevier. - 0959-6526 .- 1879-1786. ; 204, s. 183-192
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Journal article (peer-reviewed)abstract
- Increased global competition in the agricultural sector is rapidly changing the structure of farms and farming. As the number of small and diversified farms (often family-owned) decreases, the number of large and specialized farms (often corporate-owned) is increasing. In this transformation, the agricultural sector is more and more concerned with strategy, innovation, and competition in the effort to be more productive and more profitable. At the same time, the sector faces demands that it become more environmentally responsible in its policies and practices. This paper proposes a Lean Implementation Framework that small and mid-size farms can use as they aim to increase production and profit and yet support environmental sustainability. This case study takes an action-oriented research approach that focuses on the implementation of a Green Lean approach at 34 Swedish farms using various Lean tools. The paper describes how training sessions, farm visits, workshops, and counseling were used to introduce the farmers to the benefits and risks of the implementation of a new business model that added Green elements to the traditional business model design. The paper concludes with recommendations for adaptations to the Framework and suggestions for future research. © 2018
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| 8. |
- Barth, Henrik, et al.
(author)
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A new model for in vitro testing of vitreous substitute candidates
- 2014
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In: Graefe's Archives for Clinical and Experimental Ophthalmology. - Hedidelberg, Germany : Springer. - 0721-832X .- 1435-702X. ; 252:10, s. 1581-1592
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Journal article (peer-reviewed)abstract
- Purpose: To describe a new model for in vitro assessment of novel vitreous substitute candidates.Methods: The biological impact of three vitreous substitute candidates was explored in a retinal explant culture model; a polyalkylimide hydrogel (Bio-Alcamid (R)), a two component hydrogel of 20 wt.% poly (ethylene glycol) in phosphate buffered saline (PEG) and a cross-linked sodium hyaluronic acid hydrogel (Healaflow (R)). The gels where applied to explanted adult rat retinas and then kept in culture for 2, 5 and 10 days. Gel-exposed explants were compared with explants incubated under standard tissue culture conditions. Cryosections of the specimens were stained with hematoxylin and eosin, immunohistochemical markers (GFAP, Vimentin, Neurofilament 160, PKC, Rhodopsin) and TUNEL.Results: Explants kept under standard conditions as well as PEG-exposed explants displayed disruption of retinal layers with moderate pyknosis of all neurons. They also displayed moderate labeling of apoptotic cells. Bio-Alcamid (R)-exposed explants displayed severe thinning and disruption of retinal layers with massive cell death. Healaflow (R)-treated explants displayed normal retinal lamination with significantly better preservation of retinal neurons compared with control specimens, and almost no signs of apoptosis. Retinas exposed to Healaflow (R) and retinas kept under standard conditions showed variable labeling of GFAP with generally low expression and some areas of upregulation. PEG-exposed retinas showed increased GFAP labeling and Bio-Alcamid (R)-exposed retinas showed sparse labeling of GFAP.Conclusions: Research into novel vitreous substitutes has important implications for both medical and surgical vitreoretinal disease. The in vitro model presented here provides a method of biocompatibility testing prior to more costly and cumbersome in vivo experiments. The explant culture system imposes reactions within the retina including disruption of layers, cell death and gliosis, and the progression of these reactions can be used for comparison of vitreous substitute candidates. Bio-Alcamid (R) had strong adverse effects on the retina which is consistent with results of prior in vivo trials. PEG gel elicits reactions similar to the control retinas whereas Healaflow (R) shows protection from culture-induced trauma indicating favorable biocompatibility.
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| 9. |
- Barth, Henrik, et al.
(author)
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A New Retinal Detachment Treatment Model for Evaluation of Vitreous Tamponades
- 2021
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In: Current Eye Research. - : Taylor & Francis. - 0271-3683 .- 1460-2202. ; 46:3, s. 373-379
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Journal article (peer-reviewed)abstract
- PURPOSE: To develop a treatment model of rhegmatogenous retinal detachment (RRD) in which the effects of various vitreous tamponades can be explored.METHODS: In a primary session, detachment was produced in the right eye of 24 rabbits using vitrectomy, posterior vitreous detachment, retinal break induction, and subretinal injection of viscoelastic solution. The following day, detachments were treated in 16 eyes using SF6 (n = 8) or Healaflow® (HF, a cross-linked hyaluronic acid hydrogel, n = 8) tamponade. Animals were followed for 1 month and thereafter examined macroscopically and morphologically in hematoxylin and eosin-stained sections.RESULTS: Retinal detachment (RD) was successfully treated using repeated surgery. Two HF eyes developed progressive vitritis and were excluded from further evaluation. Enlargement of the initial retinal rupture with concomitant RD was seen in 4/8 SF6 eyes, while all 6 HF eyes displayed an attached retina. Attached areas showed a normal retinal morphology except for in 1 HF eye with extensive degeneration.CONCLUSIONS: The RRD repeat vitrectomy model offers a possibility to explore the efficacy and complications of novel potential vitreous tamponades. Gel-based Healaflow® displays excellent anatomic reattachment, however, vitritis and retinal degeneration in some cases warrants further investigation.
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| 10. |
- Barth, Henrik, 1971-
(author)
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Barriers to growth and development in small firms
- 2004
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Doctoral thesis (other academic/artistic)abstract
- The purpose of the extended summary is to develop the understanding of the existence and reasons behind barriers to growth and development in small firms. More specifically, four questions are addressed: (1) What do we know about the term barrier, how can it be defined? (2) What types of barriers to growth and development have been identified? (3) How can barriers to growth and development be addressed in a framework? and (4) How do the results of the appended papers (Papers I-V) contribute to the research field of barriers to growth and development?A literature review was undertaken to answer the first two questions. The literature review was conducted in two phases. The conceptual and operational definition of barriers was addressed in the first phase. The results reveal diverse ways of focusing on barriers, which made it necessary to address similar terms, such as problem and causes of business failure in the second phase of the literature review. The different terms used in the papers of the literature review are discussed in order to determine whether or not the understanding of their content is coherent and conceptual. Based on the conceptual understanding and definition of barriers, the different aspects focused on in the literature were discussed, which led to the second question, What are the various aspects of barriers to growth and development?The knowledge gained from the literature review and the development of the understanding of the barrier concept led to the third question, Can barriers to growth and development be addressed in a framework? The discussion takes its starting point in the studies identified in the literature review and is related to some of the appended papers (Papers I and II). Similarities and differences between frameworks used in the papers identified in the literature review are discussed and, based on this knowledge, a framework for barriers to growth and development in small firms is presented. The framework distinguishes two types of barriers, namely internal/external barriers and tangible/intangible barriers.The knowledge available in the reviewed papers within the field of barriers to growth and development in small firms in combination with the results from the appended papers (Papers I-V) resulted in the fourth question. Part of the contribution of the appended papers concerns the operational definition, for example that barriers to innovation should be categorised as either occurring or preventing firms from innovating (Paper II), while other contributions concern specific types of barriers, for example the importance of managerial skills (Paper V). Overall, the contribution focuses on conditional factors, such as strategy and planning, organisation and management, and institution and policy factors, in relation to growth and development.
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