| 1. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Van Eyken, Els, et al.
(författare)
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The Contribution of GJB2 (Connexin 26) 35delG to Age-Related Hearing Impairment and Noise-Induced Hearing Loss
- 2007
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Ingår i: Otology and Neurotology. - : Lippincott Williams & Wilkins. - 1531-7129 .- 1537-4505. ; 28:7, s. 970-975
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Tidskriftsartikel (refereegranskat)abstract
- Hypothesis: The common GJB2 (Connexin 26) 35delG mutation might contribute to the development of age-related hearing impairment (ARHI) and noise-induced hearing loss (NIHL).Background: GJB2, a gene encoding a gap junction protein expressed in the inner ear, has been suggested to be involved in the potassium recycling pathway in the cochlea. GJB2 mutations account for a large number of individuals with nonsyndromic recessive hearing loss, with 35delG being the most frequent mutation in populations of European origin. Other genes involved in potassium homeostasis have been suggested to be associated with ARHI and NIHL, and distortion product otoacoustic emission distortions indicative of hearing loss alterations have been found in 35delG carriers.Method: We genotyped 35delG in two distinct sample sets: an ARHI sample set, composed of 2,311 Caucasian samples from nine different centers originating from seven different countries with an age range between 53 and 67 years, and an NIHL sample set consisting of 702 samples from the two extremes of a noise-exposed Polish sample.Results: After statistical analysis, we were unable to detect an association between 35delG and ARHI, nor between 35delG and NIHL.Conclusion: Our findings indicate that there is no increased susceptibility in 35delG carriers for the development of ARHI or NIHL.
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| 3. |
- Bauer, Harald, et al.
(författare)
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Die Gobholo-Höhle in Swasiland : Expedition in eine der längsten Granithöhlen der Welt
- 2015
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Ingår i: Die Höhlen. - Wien, Österreich : Verband Österreichischer Höhlenforscher. - 0018-3091. ; 66:1-4, s. 27-42
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A small part of the Gobholo cave in westernSwaziland (southern Africa) has been usedfor touristic adventure tours for a few years,but the cave has never been surveyed norinvestigated scientifically. An internationalteam of speleologists started exploring, surveyingand documenting the cave in early2014. So far, more than 1 km has been surveyed,making Gobholo cave one of theworld’s longest granite caves and severalcontinuations are still unexplored. The upperparts of the cave are located in a rockfalldeposit overlying the Gobholo river, whereasthe lower parts originated from in-situweathering of the archaic alkali feldspargranite. The river floods large parts of thecave during heavy rainfalls and is responsiblefor the partial removal of the weatheringmaterial out of the cave. Manifold and numerousflowstones (composed of opal-Aand pigotite) probably formed via microbialprocesses. The cave is also a habitat for variousanimal species, including bats, spidersand cave crickets. Archaeologic artefactsprobably dating back to the local Stone Ageand Iron Age bear evidence of a former culturaluse of the cave. A thermal spring wasfound and temperature, CO2 and radonmeasurements provide data about the caveclimate which is characterised by fairly goodventilation. The age of the cave is uncertainbut the only approximately dated archaeologicalartefacts suggest a minimum age of40,000 years.
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| 4. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 5. |
- Oberender, Pauline, et al.
(författare)
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Gobholo Cave : A granite cave in Swaziland
- 2014
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Ingår i: International Union of Speleology Pseudokarst Commission Newsletter. - : UIS Pseudokarst Commission. ; :24, s. 29-33
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Wu, Lang, et al.
(författare)
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Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk : A Transcriptome-Wide Association Study in over 140,000 European Descendants
- 2019
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Ingår i: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 79:13, s. 3192-3204
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association study-identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain unknown. To discover novel prostate cancer genetic loci and possible causal genes at previously identified risk loci, we performed a transcriptome-wide association study in 79,194 cases and 61,112 controls of European ancestry. Using data from the Genotype-Tissue Expression Project, we established genetic models to predict gene expression across the transcriptome for both prostate models and cross-tissue models and evaluated model performance using two independent datasets. We identified significant associations for 137 genes at P < 2.61 x 10(-6), a Bonferroni-corrected threshold, including nine genes that remained significant at P < 2.61 x 10(-6) after adjusting for all known prostate cancer risk variants in nearby regions. Of the 128 remaining associated genes, 94 have not yet been reported as potential target genes at known loci. We silenced 14 genes and many showed a consistent effect on viability and colony-forming efficiency in three cell lines. Our study provides substantial new information to advance our understanding of prostate cancer genetics and biology. Significance: This study identifies novel prostate cancer genetic loci and possible causal genes, advancing our understanding of the molecular mechanisms that drive prostate cancer.
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