| 1. |
- Bastard, P, et al.
(author)
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Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1
- 2021
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 218:7
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Journal article (peer-reviewed)abstract
- Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-α subtypes and/or IFN-ω; one had anti–IFN-β and another anti–IFN-ε, but none had anti–IFN-κ. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.
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| 2. |
- Beccuti, A. G., et al.
(author)
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Hybrid control techniques for switched-mode DC-DC converters part II : The step-up topology
- 2007
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In: 2007 American Control Conference, Vols 1-13. - 1424409888 - 9781424409884 ; , s. 5464-5471
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Conference paper (peer-reviewed)abstract
- Several recent techniques from hybrid and optimal control are evaluated on a power electronics benchmark problem. The benchmark involves a number of practically interesting operating scenarios for a fixed-frequency step-up dc-dc converter. The specifications are defined such that good performance can only be obtained if the switched and nonlinear nature of the problem is respected during the design phase.
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| 3. |
- Hillberg, Emil, et al.
(author)
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Flexibility to support the future power systems
- 2019
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Conference paper (other academic/artistic)abstract
- Power system flexibility relates to the ability of the power system to manage changes. Solutions providing advances in flexibility are of utmost importance for the future power system. Development and deployment of innovative technologies, communication and monitoring possibilities, as well as increased interaction and information exchange, are enablers to provide holistic flexibility solutions. Furthermore, development of new methods for market design and analysis, as well as methods and procedures related to system planning and operation, will be required to utilise available flexibility to provide most value to society. However, flexibility is not a unified term and is lacking a commonly accepted definition. The flexibility term is used as an umbrella covering various needs and aspects in the power system. This situation makes it highly complex to discuss flexibility in the power system and craves for differentiation to enhance clarity. In this report, the solution has been to differentiate the flexibility term on needs, and to categorise flexibility needs in four categories: Flexibility for Power, Flexibility for Energy, Flexibility for Transfer Capacity, and Flexibility for Voltage. Here, flexibility needs are considered from over-all system perspectives (stability, frequency and energy supply) and from more local perspectives (transfer capacities, voltage and power quality). With flexibility support considered for both operation and planning of the power system, it is required in a timescale from fractions of a second (e.g. stability and frequency support) to minutes and hours (e.g. thermal loadings and generation dispatch) to months and years (e.g. planning for seasonal adequacy and planning of new investments). The categorisation presented in this report supports an increased understanding of the flexibility needs, to be able to identify and select the most suitable flexibility solutions.
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| 4. |
- Almér, Stefan, et al.
(author)
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Hybrid control techniques for switched-mode DC-DC converters part I : The step-down topology
- 2007
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In: 2007 American Control Conference. - : IEEE. - 1424409888 - 9781424409884 ; , s. 5450-5457
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Conference paper (peer-reviewed)abstract
- Several recent techniques from hybrid and optimal control are evaluated on a power electronics benchmark problem. The benchmark involves a number of practically interesting operating scenarios for a fixed-frequency synchronous step-down dc-dc converter. The specifications are defined such that good performance only can be obtained if the switched and nonlinear nature of the problem is respected during the design phase.
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