| 1. |
- Delling, Lotta, et al.
(författare)
-
Feasibility of bariatric surgery as a strategy for secondary prevention in cardiovascular disease: a report from the Swedish obese subjects trial.
- 2010
-
Ingår i: Journal of obesity (Online). - : Hindawi Limited. - 2090-0716 .- 2090-0708. ; 2010
-
Forskningsöversikt (refereegranskat)abstract
- Aims. Evaluation of bariatric surgery as secondary prevention in obese patients with ischemic heart disease (IHD). Methods. Analysis of data from 4047 subjects in the Swedish Obese Subjects (SOSs) study. Thirty-five patients with IHD are treated with bariatric surgery (n = 21) or conventional treatment (n = 14). Mean follow-up is 10.8 years. Results. Bariatric surgery resulted in sustained weight loss during the study period. After 2 years, the surgery group displayed significant reductions in cardiovascular risk factors, relief from cardiorespiratory symptoms, increments in physical activity, and improved quality of life. After 10 years, recovery from hypertension, diabetes, physical inactivity, and depression was still more common in the surgery group. There were no signs of increased cardiovascular morbidity or mortality in the surgery group. Conclusion. Bariatric surgery appears to be a safe and feasible treatment to achieve long-term weight loss and improvement in cardiovascular risk factors, symptoms, and quality of life in obese subjects with IHD.
|
|
| 2. |
- Behre, Carl Johan, 1968
(författare)
-
Adiponectin: a defense protein in catabolism.
- 2008
-
Ingår i: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 122:6
-
Tidskriftsartikel (refereegranskat)
|
|
| 3. |
- Behre, Carl Johan, 1968
(författare)
-
Adiponectin and its role.
- 2008
-
Ingår i: Scandinavian journal of clinical and laboratory investigation. - : Informa UK Limited. - 1502-7686 .- 0036-5513. ; 68:8, s. 678-80
-
Tidskriftsartikel (refereegranskat)
|
|
| 4. |
- Behre, Carl Johan, 1968
(författare)
-
Adiponectin, obesity and atherosclerosis.
- 2007
-
Ingår i: Scandinavian journal of clinical and laboratory investigation. - : Informa UK Limited. - 0036-5513 .- 1502-7686. ; 67:5, s. 449-58
-
Forskningsöversikt (refereegranskat)abstract
- The circulating protein adiponectin has been the subject of immense interest ever since it was first discovered in the mid-1990s. The protein is uniquely produced and secreted by mature adipocytes and is believed to have important anti-inflammatory and anti-diabetic effects; low levels have been shown to be predictive of future type 2 diabetes and cardiovascular disease. This review discusses adiponectin in relation to obesity, inflammation, insulin resistance and atherosclerosis.
|
|
| 5. |
- Behre, Carl Johan, 1968
(författare)
-
Adiponectin: saving the starved and the overfed.
- 2007
-
Ingår i: Medical hypotheses. - : Elsevier BV. - 0306-9877. ; 69:6, s. 1290-2
-
Tidskriftsartikel (refereegranskat)abstract
- The incidence of the metabolic syndrome, type 2 diabetes and cardio- and cerebrovascular disease is increasing in the Western world. The adipocyte derived protein adiponectin is thought to have a protective role against these conditions. But why is it so? Is it reasonable to believe that we have adiponectin to gain protection from welfare related diseases? Humans have had a far deadlier foe throughout history than obesity and sedentariness and that is starvation. During starvation, the body is catabolic in order to provide fuel. Catabolism is also seen in patients with advanced cardiac or renal failure, type 1 diabetes and anorexia. These subjects have higher adiponectin levels than controls. In this article, I will put forward the hypothesis that the adiponectin system evolved in order to help us to survive periods of malnourishment.
|
|
| 6. |
|
|
| 7. |
- Behre, Carl Johan, 1968, et al.
(författare)
-
Are serum adiponectin concentrations in a population sample of 64-year-old Caucasian women with varying glucose tolerance associated with ultrasound-assessed atherosclerosis?
- 2006
-
Ingår i: J Intern Med. - : Wiley. - 0954-6820. ; 260:3, s. 238-44
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To examine whether serum adiponectin concentrations were associated with subclinical atherosclerosis assessed as intima media thickness (IMT) in the carotid arteries in Caucasian women with varying degrees of glucose tolerance. RESEARCH DESIGN AND METHODS: From a population-based cohort of 64-year-old Swedish women, 533 subjects with type 2 diabetes (DM2, n=177), impaired glucose tolerance (IGT; n=178) or normal glucose tolerance (NGT, n=178) were recruited. Anthropometrics, usual cardiovascular risk factors were examined and ultrasound examination of the carotid arteries was performed. RESULTS: Women with low adiponectin concentrations were characterized by thick IMT, higher prevalence of DM2, history of previous myocardial infarction, angina pectoris, anti-hypertensive treatment and high body mass index (BMI), waist circumference, plasma insulin, serum triglycerides, fasting glucose, HbA1c, and low serum HDL cholesterol levels. Carotid IMT correlated with HbA1c (r=0.24, P<0.001), waist circumference (r=0.22, P<0.001), plasma insulin (r=0.19, P<0.001), BMI (r=0.18, P<0.001), DM2 (r=0.16, P<0.001), systolic blood pressure (r=0.16, P<0.001), blood glucose (r=0.16, P<0.001), triglycerides (r=0.15, P<0.001), and reversely to adiponectin (r=-0.11, P=0.01), HDL cholesterol (r=-0.13, P=0.004), and alcohol intake (r=-0.087, P<0.05). A more detailed analysis of underlying associations was difficult due to a high co-linearity between these variable. CONCLUSIONS: Low serum adiponectin concentrations were associated with increased carotid artery IMT, and several risk factors for cardiovascular diseases, mainly those constituting the metabolic syndrome.
|
|
| 8. |
- Behre, Carl Johan, 1968, et al.
(författare)
-
Circulating adiponectin levels are related to lean body mass independently of total fat mass and insulin
- 2009
-
Ingår i: the 3rd International Congress on Prediabetes and the Metabolic Syndrome.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Title: Circulating adiponectin levels are related to lean body mass independently of total fat mass and insulin Background: The underlying starvation hypothesis postulates that adiponectin is a fuel providing hormone in catabolic states. The hypothesis explains the high levels of adiponectin seen in different catabolic conditions and its negative correlation to insulin - an anabolic hormone. We assumed that lean body mass (LBM) is a measure of overall anabolism. The aim of this study was to test if adiponectin correlated to LBM independently of insulin and total fat. Research Design and Methods: 98 healthy 58 year old Swedish men were recruited from the AIR-study. LBM and total body fat mass were measured using the dual-energy X-ray absorptiometry body composition model. Plasma levels of adiponectin and insulin were determined by a radioimmunoassay kit. Results: In a univariate analysis, LBM correlated to log insulin (r=0.387, p<0.001), total fat mass (r=0.603, p<0.001) and log adiponectin (r=-0.262, p=0.009). In a linear logistic regression where LBM is the dependent variable and X1 is log insulin, X2 is log adiponectin and X3 is total fat mass, LBM was predicted by total fat mass (Beta 0.562, p<0.001) and log adiponectin (Beta-0.203, p=0.040). Log insulin did not significantly predict LBM in this model. Conclusions: Plasma adiponectin levels correlate negatively to LBM independently of insulin and total body fat. We interpret these cross sectional data in support of the starvation hypothesis - that adiponectin has a role in catabolism. Its negative correlation to LBM – a measure of anabolism – is in line with the postulated hypothesis.
|
|
| 9. |
- Behre, Carl Johan, 1968, et al.
(författare)
-
Dissociation between adipose tissue expression and serum levels of adiponectin during and after diet-induced weight loss in obese subjects with and without the metabolic syndrome
- 2007
-
Ingår i: Metabolism: Clinical and Experimental. - : Elsevier BV. - 0026-0495 .- 1532-8600. ; 56:8, s. 1022-8
-
Tidskriftsartikel (refereegranskat)abstract
- The study aimed to examine if dysmetabolic subjects (MetS+) have lower adiponectin gene expression and lower circulating adiponectin levels than non-dysmetabolic obese subjects (MetS-) at baseline, if adiponectin expression and adiponectin concentration rise more in the dysmetabolic group during weight loss, and if v-SNARE Vti1a (vesicle transport soluble NSF attachment protein receptor vps10p tail interacting 1a) expression increases during the weight loss, as a mechanism for increased adiponectin secretion. Twenty-one obese MetS+ and 19 obese MetS- subjects underwent a very low-energy diet for 16 weeks followed by 2 weeks of refeeding. Abdominal subcutaneous adipose tissue biopsies and blood samples were taken before, during, and after dieting for DNA microarray, reverse transcriptase-polymerase chain reaction, and biochemical analyses. Serum adiponectin was also assessed in a sex- and age-matched healthy, nonobese reference group. Weight decreased by 26.3+/-9.8 kg in the MetS+ group and 28.2+/-8.4 kg in the MetS- group with concomitant reductions in insulin, hemoglobin A1c, and triglycerides that were more pronounced in the MetS+ group. Initially, the MetS+ subjects had lower serum adiponectin, but the differences disappeared at week 8, with a continuous increase in serum adiponectin throughout the study in both groups to a level that was higher than in the reference group. The expression of adiponectin and v-SNARE Vti1a did not differ between the groups or over time. In conclusion, obese subjects with the metabolic syndrome had lower circulating adiponectin than subjects without the syndrome. Weight loss increased serum levels of adiponectin without a parallel increase in adiponectin gene expression. The mechanisms involved in the regulation of adiponectin levels merits further investigation.
|
|
| 10. |
- Behre, Carl Johan, 1968, et al.
(författare)
-
Hypoxia-inducible factor 1 is correlated to serum adiponectin levels and measures of obesity and insulin sensitivity in vivo
- 2009
-
Ingår i: International Congress on Prediabetes and the Metabolic Syndrome.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Title: Hypoxia-inducible factor 1 is correlated to serum adiponectin levels and measures of obesity and insulin sensitivity in vivo Background: Hypoxia has been shown to decrease adiponectin in vitro. Adiponectin levels are negatively associated to type 2 diabetes and cardiovascular diseases. Recently, it was shown that Hypoxia-inducible factor 1α (HIF-1) regulates adiponectin expression in murine cardiomyocytes. The present study was performed to examine the association between HIF-1 expression and serum adiponectin levels, measures of adiposity and insulin resistance in humans. Methods: Abdominal subcutaneous adipose tissue biopsies were obtained from 24 subjects diagnosed with and without the metabolic syndrome. HIF-1 gene expression was assessed by individual DNA microarray analyses. Adipose tissue depots were assessed with computerized tomography. Anthropometrics were performed. Circulating levels of insulin, adiponectin, leptin, cholesterol, high-sensitivity C - reactive protein (hs-CRP) and fasting levels of insulin and glucose were measured by standard laboratory procedures. Results: In a univariate analysis, HIF-1 expression levels correlate to BMI (r=0.42, p=0.04), WHR (r=0.55, p=0.0058), total adipose tissue (r=0.46, p=0.022), subcutaneous adipose tissue ( r=0.49, p= 0.016),liver fat (r=0.44, p=0.030), fasting insulin (r=0.46, p=0.023), HOMA-index (r=0.46, p=0.023) and serum adiponectin (r= -0.42, p=0.0418). We observed no statistically significant correlations between HIF-1 gene expression and visceral adipose tissue, systolic blood pressure, serum cholesterol, hs-CRP or serum leptin. HIF-1 gene expression did not differ between the groups. Conclusions: We report that expression of HIF-1 is correlated to serum adiponectin, insulin sensitivity and measures of adiposity. There were no statistical differences in expression of HIF-1 between subjects with or without the metabolic syndrome. In this cross-sectional analysis, no conclusions can be drawn about causality.
|
|
